WO2008049269A1 - Système de commande précise pour appareil de traitement in vitro par ultrasons à haute énergie focalisés et procédé associé - Google Patents

Système de commande précise pour appareil de traitement in vitro par ultrasons à haute énergie focalisés et procédé associé Download PDF

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Publication number
WO2008049269A1
WO2008049269A1 PCT/CN2006/002845 CN2006002845W WO2008049269A1 WO 2008049269 A1 WO2008049269 A1 WO 2008049269A1 CN 2006002845 W CN2006002845 W CN 2006002845W WO 2008049269 A1 WO2008049269 A1 WO 2008049269A1
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WO
WIPO (PCT)
Prior art keywords
time
output
energy focused
command
ultrasound
Prior art date
Application number
PCT/CN2006/002845
Other languages
English (en)
Chinese (zh)
Inventor
Ling Xiao
Xingbo Fei
Xiaoming Zhang
Jinsheng Yu
Xiaodong Wu
Original Assignee
Haifuning Hifu Technology (Beijing) Co., Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Haifuning Hifu Technology (Beijing) Co., Ltd filed Critical Haifuning Hifu Technology (Beijing) Co., Ltd
Priority to CN2006800561762A priority Critical patent/CN101557763B/zh
Priority to PCT/CN2006/002845 priority patent/WO2008049269A1/fr
Publication of WO2008049269A1 publication Critical patent/WO2008049269A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/378—Surgical systems with images on a monitor during operation using ultrasound

Definitions

  • the invention relates to an accurate control system for an in vitro high-energy focused ultrasonic therapeutic machine, which can be used for a pre-external high-energy focused ultrasonic therapeutic machine, which can observe the breathing condition of the treated object during the treatment process, so that the ultrasonic energy is only breathed in the treated object.
  • the relatively smooth period of motion of the motion is used to improve the focus accuracy during treatment and reduce the unnecessary damage of normal tissue. Background technique
  • ultrasound treatment devices typically employ an ultrasound imaging system or a nuclear magnetic resonance imaging system for localization during treatment. During the course of treatment, there is no effective real-time dynamic control method for the treatment area error caused by breathing or other actions. Summary of the invention
  • the object of the present invention is to provide a precise control system for an in vitro ⁇ -focusing ultrasound treatment machine, which can determine the time period during which the treatment object moves due to breathing by extracting ultrasound image data, and during the time period. Stopping the emission of therapeutic ultrasound energy to reduce damage to normal tissue during ultrasound therapy -
  • an accurate control system for an in vitro high energy focused ultrasound therapy machine comprising: An ultrasound imaging system that treats a target and detects its movement state; an acquisition system for acquiring an image of the ultrasound image; and an ultrasound source control section that calculates a breathing of the treatment subject based on the output of the acquisition system The movement information of the treatment area is generated, and the control instruction for the ultrasonic source to emit or stop the emission is output.
  • the ultrasonic source control portion includes a continuous picture calculation program that extracts relevant statistical information by extracting information corresponding to the relevant region.
  • the ultrasound source control portion includes control strategy software including a user software interface that determines the transmission status based on user requirements, internal computational processing software, and an output program that controls the ultrasound source transmission instructions.
  • an in vitro high energy focused ultrasound therapeutic apparatus comprising:
  • a precise control method for in vitro high-energy focused ultrasound therapy comprising: searching for a treatment target and acquiring an ultrasound image thereof; and calculating a treatment caused by the respiratory response of the treatment object according to the collected output The movement information of the area, thereby outputting a control command, controlling the emission of the ultrasonic source or stopping the transmission.
  • a computer program product which, when located in a random access memory of a computer and executed by a processor, performs the following steps: causing a high energy focused ultrasound therapy device to find a treatment target and collect the ultrasound And an image of the image; and, according to the collected output, calculating movement information of the treatment area caused by the breathing of the treatment object, thereby outputting a control instruction to control the emission of the ultrasonic source or to stop the emission.
  • FIG. 1 shows a flow chart D of one embodiment of an accurate control method for extracorporeal high energy focused ultrasound therapy in accordance with the present invention.
  • the invention designs a precise control system for an in vitro high energy focused ultrasound therapy machine and a precise control method for in vitro high energy focused ultrasound therapy.
  • the precise control system and the precise control method are mainly used to solve the problem of error movement of the treatment area due to the breathing of the treatment subject.
  • the system for precise control of the in vitro high-energy focused ultrasound therapeutic machine designed by the invention comprises: an ultrasound imaging system for finding a treatment target and detecting its movement state; an acquisition system for acquiring an ultrasound image picture; and an ultrasonic source control part, The control part calculates movement information of the treatment area caused by the breathing of the treatment object according to the output of the collection system, and outputs a control instruction for the ultrasonic source to emit or stop the emission.
  • the ultrasound imaging system mainly uses black and white B-super or color Doppler ultrasound imager. The corresponding continuous ultrasound image is obtained by using the picture output function of the black and white B-super or color Doppler ultrasound imager.
  • a dedicated image capture device such as a number of endoscopes. If conditions are available to directly utilize the RF signal provided by the ultrasound imaging instrument, a two-dimensional digital signal with a dedicated statistic can be generated, such as a Schmitt-based trigger and amplifier circuit topology (IC1B and IC1C) to convert the RF signal to representation A two-dimensional digital signal measuring amplitude and speed, on the basis of which more accurate positioning information can be obtained.
  • IC1B and IC1C Schmitt-based trigger and amplifier circuit topology
  • the ultrasonic source control portion includes a continuous picture calculation program that extracts relevant statistical information by extracting information corresponding to the relevant region.
  • the ultrasound source control portion further includes control strategy software including a user software interface that determines a transmission state based on user requirements, internal arithmetic processing software, and an output program that controls the ultrasound source transmission instructions.
  • the ultrasonic source control portion of the present invention acquires a continuous ultrasonic image Or based on the dedicated two-dimensional digital signal, the relevant statistical information is extracted by using information corresponding to the relevant region.
  • the control part can provide the user with the necessary user interface interface, and the user interface interface can be input by the user, including the reason why the statistic value is transmitted, and when the statistic value is stopped, the parameter input is stopped.
  • the corresponding wave source control command is output to the ultrasonic therapy machine through the internal arithmetic processing software.
  • the control portion of the present invention can have two implementations when providing the extraction of statistical information. One is to pay attention to the mean value g(i) of the target region S at the corresponding time ⁇ ,
  • /O represents the numerical value of the point in time s (for example, it can be its coordinate), which represents the sum of the numerical quantities of all points in time f of s.
  • the control portion of the present invention also provides two implementations of control strategy software algorithms.
  • the first embodiment is to calculate first
  • g, ⁇ t ⁇ g ⁇ t - d) - g ⁇ t) ⁇ ( 3 )
  • d is the time difference between successive picture intervals, and therefore represents the absolute value of the difference between the number of consecutive pictures g and g -
  • the threshold value and the length of the time window are specified, and the emission command is output at the i+th time after the point t corresponding to the local maximum of the g x ( ) in the time period, and the output command is stopped at the first moment.
  • Another implementation of the control strategy software algorithm is to first utilize fast and rich
  • the leaf transformation method calculates the corresponding respiratory cycle time ⁇ 0 :
  • o 'er(g() denotes the Fourier transform of g, denoted as ⁇ 0 is the maximum value of the GO in the region corresponding to the t period)
  • the present invention also provides an in vitro high energy focused ultrasound therapy machine comprising an ultrasound source and the precision control system described above, the output of the control system including control commands for controlling the emission of the ultrasound source or stopping the transmission.
  • the ultrasonic energy can be emitted only during a relatively smooth period of the respiratory motion of the subject, to improve the focus accuracy during the treatment, and to reduce the unnecessary degree of damage of the normal tissue.
  • Figure 1 is a flow chart showing one embodiment of an accurate control method for extracorporeal high energy focused ultrasound therapy in accordance with the present invention.
  • the method begins with step 101. First, an ultrasound image image is acquired for the target using, for example, an ultrasound imaging system and an acquisition system (step 102). Then, the control portion that controls the ultrasonic source extracts relevant statistical information by extracting information corresponding to the relevant region (step 103).
  • any of the following schemes may be implemented: ( ⁇ ) - the type is the numerical mean value of the target region S at the corresponding time ⁇ , using the formula ( The method of 1) (step 1041); ( ⁇ ) Another scheme is to focus on the weighted center of gravity of the target region S at the corresponding time t, using the method of equation (2) (step 1042).
  • the control strategy algorithm may perform any one of the following two schemes:
  • ( ⁇ ) Another scheme is to first calculate the respiratory cycle time g corresponding to g (0) using the fast Fourier transform method:
  • a high energy focused ultrasound therapy device has a random access memory (RAM) and a CPU or MPU executing the program therein, which can receive and store computer programs and applications as temporary and/or non-easy Computer readable instructions of a dysfunctional state.
  • the high energy focused ultrasound therapy device can further have a hard disk drive that reads from and writes to the hard disk, a disk drive that reads from and writes to the disk, and/or an optical disk drive that reads from and writes to the optical disk.
  • Examples of storage media include, but are not limited to, CD-ROM, magneto-optical disks, ROM, RAM, EPROM, EEPROM, high-speed flash memory, magnetic or optical cards, DVDs, or any type of medium suitable for storing electronic instructions.
  • the present invention can also be conveniently implemented by a conventional general purpose digital computer that teaches programming. That is, when a computer loads and executes appropriate software code or programs, these appropriate software code or programs can perform all or a portion of the method steps of the present invention. The execution of these programs or the program itself is also an embodiment of the present invention. Suitable software code or programs that are readily prepared by one of ordinary skill in the art based on the teachings of the present invention will be apparent to those of ordinary skill in the software arts. In particular, one of ordinary skill in the art will recognize that there are many computer languages (including but not limited to:

Abstract

L'invention concerne un système de commande précise pour un appareil de traitement in vitro par ultrasons à haute énergie focalisés, ainsi qu'un procédé associé. Le système comprend un système de formation d'images par ultrasons conçu pour localiser un objet à traiter et en détecter le mouvement; un système d'acquisition conçu pour acquérir les images formées par ultrasons; et un composant de commande de source d'ondes ultrasonores. Le composant de commande calcule des informations relatives au mouvement d'une zone à traiter provoqué par la respiration de l'objet à traiter, en fonction de la sortie du système d'acquisition et transmet à la source d'ondes ultrasonores des signaux de commande pour déclencher ou bloquer l'émission d'une onde ultrasonore.
PCT/CN2006/002845 2006-10-24 2006-10-24 Système de commande précise pour appareil de traitement in vitro par ultrasons à haute énergie focalisés et procédé associé WO2008049269A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN2006800561762A CN101557763B (zh) 2006-10-24 2006-10-24 体外高能聚焦超声波治疗机的精准控制系统
PCT/CN2006/002845 WO2008049269A1 (fr) 2006-10-24 2006-10-24 Système de commande précise pour appareil de traitement in vitro par ultrasons à haute énergie focalisés et procédé associé

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2006/002845 WO2008049269A1 (fr) 2006-10-24 2006-10-24 Système de commande précise pour appareil de traitement in vitro par ultrasons à haute énergie focalisés et procédé associé

Publications (1)

Publication Number Publication Date
WO2008049269A1 true WO2008049269A1 (fr) 2008-05-02

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PCT/CN2006/002845 WO2008049269A1 (fr) 2006-10-24 2006-10-24 Système de commande précise pour appareil de traitement in vitro par ultrasons à haute énergie focalisés et procédé associé

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CN (1) CN101557763B (fr)
WO (1) WO2008049269A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4865042A (en) * 1985-08-16 1989-09-12 Hitachi, Ltd. Ultrasonic irradiation system
US20020115923A1 (en) * 2000-11-22 2002-08-22 Stephan Erbel Method for determining a current lung filling extent and method for assisting radiation therapy during respiratory shifting of the radiation target
US20040081269A1 (en) * 2002-10-23 2004-04-29 Tin-Su Pan Retrospective respiratory gating for imaging and treatment
US6731970B2 (en) * 2000-07-07 2004-05-04 Brainlab Ag Method for breath compensation in radiation therapy
WO2006057911A2 (fr) * 2004-11-22 2006-06-01 Civco Medical Instruments Co., Inc. Suivi ultrasonore en temps reel du mouvement de structure internes durant la respiration pour le controle d'administration de traitement

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4865042A (en) * 1985-08-16 1989-09-12 Hitachi, Ltd. Ultrasonic irradiation system
US6731970B2 (en) * 2000-07-07 2004-05-04 Brainlab Ag Method for breath compensation in radiation therapy
US20020115923A1 (en) * 2000-11-22 2002-08-22 Stephan Erbel Method for determining a current lung filling extent and method for assisting radiation therapy during respiratory shifting of the radiation target
US20040081269A1 (en) * 2002-10-23 2004-04-29 Tin-Su Pan Retrospective respiratory gating for imaging and treatment
WO2006057911A2 (fr) * 2004-11-22 2006-06-01 Civco Medical Instruments Co., Inc. Suivi ultrasonore en temps reel du mouvement de structure internes durant la respiration pour le controle d'administration de traitement

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CN101557763B (zh) 2011-11-30
CN101557763A (zh) 2009-10-14

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