WO2008048648A3 - Cb1-modulating compounds and their use - Google Patents

Cb1-modulating compounds and their use Download PDF

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Publication number
WO2008048648A3
WO2008048648A3 PCT/US2007/022183 US2007022183W WO2008048648A3 WO 2008048648 A3 WO2008048648 A3 WO 2008048648A3 US 2007022183 W US2007022183 W US 2007022183W WO 2008048648 A3 WO2008048648 A3 WO 2008048648A3
Authority
WO
WIPO (PCT)
Prior art keywords
compound
formula
disclosed
modulating compounds
subject
Prior art date
Application number
PCT/US2007/022183
Other languages
French (fr)
Other versions
WO2008048648A2 (en
Inventor
Roger Olsson
Anne Bulow
Original Assignee
Acadia Pharm Inc
Roger Olsson
Anne Bulow
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acadia Pharm Inc, Roger Olsson, Anne Bulow filed Critical Acadia Pharm Inc
Publication of WO2008048648A2 publication Critical patent/WO2008048648A2/en
Publication of WO2008048648A3 publication Critical patent/WO2008048648A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Addiction (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

Disclosed herein is a compound of Formula (I). Also disclosed herein is a method of modulating the activity of a cannabinoid receptor using a compound of Formula (I). Furthermore, disclosed herein is a method of treating a disease or condition that would be alleviated, improved or prevented by administration of a compound that modulates a cannabinoid receptor comprising identifying a subject in need thereof and administering to said subject a therapeutically effective amount of a compound of Formula (I). Also disclosed herein are pharmaceutical compositions comprising a compound of Formula (I).
PCT/US2007/022183 2006-10-17 2007-10-17 Cb1-modulating compounds and their use WO2008048648A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85257906P 2006-10-17 2006-10-17
US60/852,579 2006-10-17

Publications (2)

Publication Number Publication Date
WO2008048648A2 WO2008048648A2 (en) 2008-04-24
WO2008048648A3 true WO2008048648A3 (en) 2008-06-12

Family

ID=39204737

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/022183 WO2008048648A2 (en) 2006-10-17 2007-10-17 Cb1-modulating compounds and their use

Country Status (1)

Country Link
WO (1) WO2008048648A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2025674A1 (en) 2007-08-15 2009-02-18 sanofi-aventis Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs
US8557738B2 (en) 2008-08-12 2013-10-15 Nippon Soda Co., Ltd. Nitrogen-containing heterocyclic derivative and fungicide for agricultural and horticultural use
KR101435729B1 (en) 2009-09-28 2014-09-01 닛뽕소다 가부시키가이샤 Nitrogen-containing heterocyclic compound and salt thereof, and bactericide for agricultural and horticultural use
CN102807574B (en) * 2011-05-30 2015-09-02 长春吉大天元化学技术股份有限公司 New pyridine sulphur nitrogen seven-membered ring derivative as antitumor drug, and its preparation method and application
ES2915101T3 (en) 2014-03-27 2022-06-20 Bird Rock Bio Inc Antibodies that bind to the human cannabinoid receptor 1 (CB1)
SG10202100916PA (en) 2015-02-02 2021-02-25 Valo Early Discovery Inc 3-aryl-4-amido-bicyclic [4,5,0] hydroxamic acids as hdac inhibitors
US10183934B2 (en) 2015-02-02 2019-01-22 Forma Therapeutics, Inc. Bicyclic [4,6,0] hydroxamic acids as HDAC inhibitors
MA43049A (en) 2015-09-30 2018-08-08 Bird Rock Bio Inc HUMAN CANNABINOID 1 RECEPTOR BODY ANTIBODIES (CB1)
EP3472131B1 (en) 2016-06-17 2020-02-19 Forma Therapeutics, Inc. 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005044822A1 (en) * 2003-11-07 2005-05-19 Pfizer Products Inc. Bicyclic pyrazolyl and imidazolyl compounds and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005044822A1 (en) * 2003-11-07 2005-05-19 Pfizer Products Inc. Bicyclic pyrazolyl and imidazolyl compounds and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HOWLETT A C ET AL: "Cannabinoid physiology and pharmacology: 30 years of progress", NEUROPHARMACOLOGY, PERGAMON PRESS, OXFORD, GB, vol. 47, 2004, pages 345 - 358, XP004612197, ISSN: 0028-3908 *

Also Published As

Publication number Publication date
WO2008048648A2 (en) 2008-04-24

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