WO2008045998A3 - Enantiomerically enriched iminopyrrolidone aziridine compositions - Google Patents

Enantiomerically enriched iminopyrrolidone aziridine compositions Download PDF

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Publication number
WO2008045998A3
WO2008045998A3 PCT/US2007/081085 US2007081085W WO2008045998A3 WO 2008045998 A3 WO2008045998 A3 WO 2008045998A3 US 2007081085 W US2007081085 W US 2007081085W WO 2008045998 A3 WO2008045998 A3 WO 2008045998A3
Authority
WO
WIPO (PCT)
Prior art keywords
enantiomerically enriched
compositions
iminopyrrolidone
aziridine
methods
Prior art date
Application number
PCT/US2007/081085
Other languages
French (fr)
Other versions
WO2008045998A2 (en
Inventor
Philip J A Kuehl
William A Remers
Original Assignee
Univ Arizona
Amplimed Corp
Philip J A Kuehl
William A Remers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Arizona, Amplimed Corp, Philip J A Kuehl, William A Remers filed Critical Univ Arizona
Publication of WO2008045998A2 publication Critical patent/WO2008045998A2/en
Publication of WO2008045998A3 publication Critical patent/WO2008045998A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Enantiomerically enriched iminopyrrolidone aziridine compositions are disclosed herein. Embodiments of the present invention include enantiomerically enriched compositions, aqueous solutions of, and methods of increasing the aqueous solubility of, enantiomerically enriched compositions, and methods of formulating drug products comprising enantiomerically enriched iminopyrrolidone aziridine compounds for use in the treatment of cancer.
PCT/US2007/081085 2006-10-12 2007-10-11 Enantiomerically enriched iminopyrrolidone aziridine compositions WO2008045998A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85135806P 2006-10-12 2006-10-12
US60/851,358 2006-10-12

Publications (2)

Publication Number Publication Date
WO2008045998A2 WO2008045998A2 (en) 2008-04-17
WO2008045998A3 true WO2008045998A3 (en) 2008-09-18

Family

ID=39283505

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2007/079613 WO2008045686A2 (en) 2006-10-12 2007-09-27 Enantiomerically enriched iminopyrrolidone azirdine compositions
PCT/US2007/081085 WO2008045998A2 (en) 2006-10-12 2007-10-11 Enantiomerically enriched iminopyrrolidone aziridine compositions

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2007/079613 WO2008045686A2 (en) 2006-10-12 2007-09-27 Enantiomerically enriched iminopyrrolidone azirdine compositions

Country Status (1)

Country Link
WO (2) WO2008045686A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4083987A (en) * 1975-07-08 1978-04-11 Boehringer Mannheim Gmbh 4-Imino-1,3-diazabicyclo-(3.1.0)-hexan-2-one as a cancerostat and immuno-stimulant

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5949018B2 (en) * 1976-10-15 1984-11-30 旭化成株式会社 drug syringe
WO1999000120A1 (en) * 1997-06-27 1999-01-07 Arizona Board Of Regents, University Of Arizona Novel cyanoaziridines for treating cancer
US20030153771A1 (en) * 2001-09-27 2003-08-14 Kolb Hartmuth C. Large scale synthesis of optically pure aziridines
US6476236B1 (en) * 2001-11-26 2002-11-05 The Arizona Board Of Regents Synthesis of 2-cyanoaziridine-1-carboxamide
JP3772219B2 (en) * 2003-02-12 2006-05-10 九州大学長 Process for producing optically active aziridine compound and amine compound

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4083987A (en) * 1975-07-08 1978-04-11 Boehringer Mannheim Gmbh 4-Imino-1,3-diazabicyclo-(3.1.0)-hexan-2-one as a cancerostat and immuno-stimulant

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DEN BROK ET AL.: "The pharmaceutical development of a lyophilised dosage from for the investigational anticancer agent imexon using dimethyl sulfoxide as solubilising and stabilising agent", IMEXON, vol. CHAPTER 1.2, 6 December 2004 (2004-12-06), pages 43 - 64 *
DUDDU ET AL.: "Formation of the Racemic Compound of Ephedrine Base from a Physical Mixture of its Enantiomers in the Solid, Liquid, Solution, or Vapor State", PHARMACEUTICAL RESEARCH, vol. 9, no. 8, August 1992 (1992-08-01), pages 1083 - 1091 *
HICKS ET AL.: "Preparation And Antitumor Activity Of Imexon Enantiomers", 30TH NATIONAL MEDICINAL CHEMISTRY SYMPOSIUM, UNIVERSITY OF WASHINGTON, SEATTLE, MEETING ABSTRACT #149, 25 June 2006 (2006-06-25) - 29 June 2006 (2006-06-29), pages 9 *

Also Published As

Publication number Publication date
WO2008045686A2 (en) 2008-04-17
WO2008045686A3 (en) 2008-07-24
WO2008045998A2 (en) 2008-04-17

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