WO2008045686A3 - Enantiomerically enriched iminopyrrolidone azirdine compositions - Google Patents

Enantiomerically enriched iminopyrrolidone azirdine compositions Download PDF

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Publication number
WO2008045686A3
WO2008045686A3 PCT/US2007/079613 US2007079613W WO2008045686A3 WO 2008045686 A3 WO2008045686 A3 WO 2008045686A3 US 2007079613 W US2007079613 W US 2007079613W WO 2008045686 A3 WO2008045686 A3 WO 2008045686A3
Authority
WO
WIPO (PCT)
Prior art keywords
enantiomerically enriched
compositions
iminopyrrolidone
azirdine
methods
Prior art date
Application number
PCT/US2007/079613
Other languages
French (fr)
Other versions
WO2008045686A2 (en
Inventor
Philip J A Kuehl
William A Remers
Original Assignee
Univ Arizona
Amplimed Corp
Philip J A Kuehl
William A Remers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Arizona, Amplimed Corp, Philip J A Kuehl, William A Remers filed Critical Univ Arizona
Publication of WO2008045686A2 publication Critical patent/WO2008045686A2/en
Publication of WO2008045686A3 publication Critical patent/WO2008045686A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil

Abstract

Enantiomerically enriched iminopyrrolidone aziridine compositions are disclosed herein. Embodiments of the present invention include enantiomerically enriched compositions, aqueous solutions of, and methods of increasing the aqueous solubility of, enantiomerically enriched compositions, and methods of formulating drug products comprising enantiomerically enriched iminopyrrolidone aziridine compounds for use in the treatment of cancer.
PCT/US2007/079613 2006-10-12 2007-09-27 Enantiomerically enriched iminopyrrolidone azirdine compositions WO2008045686A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85135806P 2006-10-12 2006-10-12
US60/851,358 2006-10-12

Publications (2)

Publication Number Publication Date
WO2008045686A2 WO2008045686A2 (en) 2008-04-17
WO2008045686A3 true WO2008045686A3 (en) 2008-07-24

Family

ID=39283505

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2007/079613 WO2008045686A2 (en) 2006-10-12 2007-09-27 Enantiomerically enriched iminopyrrolidone azirdine compositions
PCT/US2007/081085 WO2008045998A2 (en) 2006-10-12 2007-10-11 Enantiomerically enriched iminopyrrolidone aziridine compositions

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2007/081085 WO2008045998A2 (en) 2006-10-12 2007-10-11 Enantiomerically enriched iminopyrrolidone aziridine compositions

Country Status (1)

Country Link
WO (2) WO2008045686A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4267053A (en) * 1976-10-15 1981-05-12 Asahi Kasei Kogyo Kabushiki Kaisha Inline intravenous final filter unit
US6297230B1 (en) * 1997-06-27 2001-10-02 Amplimed, Inc. Cyanoaziridines for treating cancer
US6476236B1 (en) * 2001-11-26 2002-11-05 The Arizona Board Of Regents Synthesis of 2-cyanoaziridine-1-carboxamide
US20030153771A1 (en) * 2001-09-27 2003-08-14 Kolb Hartmuth C. Large scale synthesis of optically pure aziridines
US20040220413A1 (en) * 2003-02-12 2004-11-04 Kyushu University Method of producing optically active aziridine compounds and amine compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2530398A1 (en) * 1975-07-08 1977-01-27 Boehringer Mannheim Gmbh ORGANIC CONNECTION

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4267053A (en) * 1976-10-15 1981-05-12 Asahi Kasei Kogyo Kabushiki Kaisha Inline intravenous final filter unit
US6297230B1 (en) * 1997-06-27 2001-10-02 Amplimed, Inc. Cyanoaziridines for treating cancer
US20030153771A1 (en) * 2001-09-27 2003-08-14 Kolb Hartmuth C. Large scale synthesis of optically pure aziridines
US6476236B1 (en) * 2001-11-26 2002-11-05 The Arizona Board Of Regents Synthesis of 2-cyanoaziridine-1-carboxamide
US20040220413A1 (en) * 2003-02-12 2004-11-04 Kyushu University Method of producing optically active aziridine compounds and amine compounds

Also Published As

Publication number Publication date
WO2008045998A3 (en) 2008-09-18
WO2008045998A2 (en) 2008-04-17
WO2008045686A2 (en) 2008-04-17

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