WO2008044153A3 - Improved method for synthesizing rimonabant - Google Patents

Improved method for synthesizing rimonabant Download PDF

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Publication number
WO2008044153A3
WO2008044153A3 PCT/IB2007/004313 IB2007004313W WO2008044153A3 WO 2008044153 A3 WO2008044153 A3 WO 2008044153A3 IB 2007004313 W IB2007004313 W IB 2007004313W WO 2008044153 A3 WO2008044153 A3 WO 2008044153A3
Authority
WO
WIPO (PCT)
Prior art keywords
rimonabant
synthesizing
improved method
relates
minimizing
Prior art date
Application number
PCT/IB2007/004313
Other languages
French (fr)
Other versions
WO2008044153A2 (en
Inventor
Velez Monica Benito
Stephen Winter
Lopez Ernesto Duran
Original Assignee
Medichem Sa
Velez Monica Benito
Stephen Winter
Lopez Ernesto Duran
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem Sa, Velez Monica Benito, Stephen Winter, Lopez Ernesto Duran filed Critical Medichem Sa
Publication of WO2008044153A2 publication Critical patent/WO2008044153A2/en
Publication of WO2008044153A3 publication Critical patent/WO2008044153A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)

Abstract

The invention relates to a process for preparing rimonabant. In particular, the invention relates to minimizing the presence and effects of certain by-products of formula (III) and impurities present in rimonabant occurring during the synthesis of rimonabant.
PCT/IB2007/004313 2006-08-29 2007-08-29 Improved method for synthesizing rimonabant WO2008044153A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US84069506P 2006-08-29 2006-08-29
US60/840,695 2006-08-29
US92409607P 2007-04-30 2007-04-30
US60/924,096 2007-04-30

Publications (2)

Publication Number Publication Date
WO2008044153A2 WO2008044153A2 (en) 2008-04-17
WO2008044153A3 true WO2008044153A3 (en) 2008-10-09

Family

ID=39283251

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/004313 WO2008044153A2 (en) 2006-08-29 2007-08-29 Improved method for synthesizing rimonabant

Country Status (2)

Country Link
AR (1) AR062593A1 (en)
WO (1) WO2008044153A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105548161A (en) * 2015-12-10 2016-05-04 山东省食品药品检验研究院 Rapid detection method for rimonabant

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008062480A2 (en) * 2006-11-24 2008-05-29 Ind-Swift Laboratories Limited An improved process for the preparation of rimonabant
WO2008088900A2 (en) * 2007-01-18 2008-07-24 Teva Pharmaceutical Industries Ltd. Polymorphic forms of rimonabant base and processes for preparation thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050043356A1 (en) * 2001-11-08 2005-02-24 Alain Alcade Polymorphic form of rimonabant method for preparing it and pharmaceutical compositions containing it

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050043356A1 (en) * 2001-11-08 2005-02-24 Alain Alcade Polymorphic form of rimonabant method for preparing it and pharmaceutical compositions containing it

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DUTTA A K ET AL: "THE SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF THE CANNABINOID ANTAGONIST SR 141716A", MEDICINAL CHEMISTRY RESEARCH, BIRKHAEUSER, BOSTON, US, vol. 5, no. 1, 1 January 1995 (1995-01-01), pages 54 - 62, XP009026011, ISSN: 1054-2523 *
SELTZMAN HERBERT H ET AL: "Tritiation of SR141716 by metallation-iodination-reduction: Tritium-proton nOe study", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 45, no. 1, January 2002 (2002-01-01), pages 59 - 70, XP002485625, ISSN: 0362-4803 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105548161A (en) * 2015-12-10 2016-05-04 山东省食品药品检验研究院 Rapid detection method for rimonabant
CN105548161B (en) * 2015-12-10 2018-01-30 山东省食品药品检验研究院 A kind of quick determination method of Rimonabant

Also Published As

Publication number Publication date
AR062593A1 (en) 2008-11-19
WO2008044153A2 (en) 2008-04-17

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