WO2008042404A3 - Electrokinetic system and method for delivering methotrexate - Google Patents

Electrokinetic system and method for delivering methotrexate Download PDF

Info

Publication number
WO2008042404A3
WO2008042404A3 PCT/US2007/021226 US2007021226W WO2008042404A3 WO 2008042404 A3 WO2008042404 A3 WO 2008042404A3 US 2007021226 W US2007021226 W US 2007021226W WO 2008042404 A3 WO2008042404 A3 WO 2008042404A3
Authority
WO
WIPO (PCT)
Prior art keywords
applicator
methotrexate
needles
micro
conductive
Prior art date
Application number
PCT/US2007/021226
Other languages
French (fr)
Other versions
WO2008042404A2 (en
Inventor
Robert W Etheredge Iii
Dennis I Goldberg
Phillip M Friden
John S Petersen
Original Assignee
Transport Pharmaceuticals Inc
Robert W Etheredge Iii
Dennis I Goldberg
Phillip M Friden
John S Petersen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transport Pharmaceuticals Inc, Robert W Etheredge Iii, Dennis I Goldberg, Phillip M Friden, John S Petersen filed Critical Transport Pharmaceuticals Inc
Priority to JP2009531436A priority Critical patent/JP2010505518A/en
Priority to EP07852505A priority patent/EP2079515A2/en
Publication of WO2008042404A2 publication Critical patent/WO2008042404A2/en
Publication of WO2008042404A3 publication Critical patent/WO2008042404A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Electrotherapy Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The electrokinetic methotrexate delivery system includes at least one applicator having a multiplicity of non-conductive micro-needles carried on a non-conductive surface of the applicator. The opposite surface is formed of electrically conductive material for contact with an active electrode. The applicator includes a matrix containing a medicament, e.g., methotrexate, or a carrier therefor between the opposite surfaces. When the applicator is applied to the individual's skin with the micro-needles penetrating the skin, an electrical current is completed through the power source, the active electrode, methotrexate, or electrically conductive carrier therefor, the targeted treatment site, the individual's body, a ground electrode and the power supply, thereby electokinetically driving the medicament through the non-conductive micro-needles into the targeted treatment site.
PCT/US2007/021226 2006-10-03 2007-10-03 Electrokinetic system and method for delivering methotrexate WO2008042404A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2009531436A JP2010505518A (en) 2006-10-03 2007-10-03 Electrokinetic system and method for delivering methotrexate
EP07852505A EP2079515A2 (en) 2006-10-03 2007-10-03 Electrokinetic system and method for delivering methotrexate

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/538,249 2006-10-03
US11/538,249 US20070185432A1 (en) 2005-09-19 2006-10-03 Electrokinetic system and method for delivering methotrexate

Publications (2)

Publication Number Publication Date
WO2008042404A2 WO2008042404A2 (en) 2008-04-10
WO2008042404A3 true WO2008042404A3 (en) 2008-08-07

Family

ID=39269032

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/021226 WO2008042404A2 (en) 2006-10-03 2007-10-03 Electrokinetic system and method for delivering methotrexate

Country Status (4)

Country Link
US (1) US20070185432A1 (en)
EP (1) EP2079515A2 (en)
JP (1) JP2010505518A (en)
WO (1) WO2008042404A2 (en)

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Also Published As

Publication number Publication date
EP2079515A2 (en) 2009-07-22
JP2010505518A (en) 2010-02-25
WO2008042404A2 (en) 2008-04-10
US20070185432A1 (en) 2007-08-09

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