WO2008041866A3 - Procédé d'extraction de spectre de rmn - Google Patents

Procédé d'extraction de spectre de rmn Download PDF

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Publication number
WO2008041866A3
WO2008041866A3 PCT/NZ2007/000287 NZ2007000287W WO2008041866A3 WO 2008041866 A3 WO2008041866 A3 WO 2008041866A3 NZ 2007000287 W NZ2007000287 W NZ 2007000287W WO 2008041866 A3 WO2008041866 A3 WO 2008041866A3
Authority
WO
WIPO (PCT)
Prior art keywords
sample
under investigation
nmr
sample under
nmr spectra
Prior art date
Application number
PCT/NZ2007/000287
Other languages
English (en)
Other versions
WO2008041866A2 (fr
Inventor
Paul Terence Callaghan
Meghan Eileen Halse
Original Assignee
Victoria Link Ltd
Paul Terence Callaghan
Meghan Eileen Halse
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Victoria Link Ltd, Paul Terence Callaghan, Meghan Eileen Halse filed Critical Victoria Link Ltd
Priority to AU2007302889A priority Critical patent/AU2007302889A1/en
Publication of WO2008041866A2 publication Critical patent/WO2008041866A2/fr
Publication of WO2008041866A3 publication Critical patent/WO2008041866A3/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/4625—Processing of acquired signals, e.g. elimination of phase errors, baseline fitting, chemometric analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/483—NMR imaging systems with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy
    • G01R33/485—NMR imaging systems with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy based on chemical shift information [CSI] or spectroscopic imaging, e.g. to acquire the spatial distributions of metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/561—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences
    • G01R33/5615—Echo train techniques involving acquiring plural, differently encoded, echo signals after one RF excitation, e.g. using gradient refocusing in echo planar imaging [EPI], RF refocusing in rapid acquisition with relaxation enhancement [RARE] or using both RF and gradient refocusing in gradient and spin echo imaging [GRASE]
    • G01R33/5616—Echo train techniques involving acquiring plural, differently encoded, echo signals after one RF excitation, e.g. using gradient refocusing in echo planar imaging [EPI], RF refocusing in rapid acquisition with relaxation enhancement [RARE] or using both RF and gradient refocusing in gradient and spin echo imaging [GRASE] using gradient refocusing, e.g. EPI
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/565—Correction of image distortions, e.g. due to magnetic field inhomogeneities
    • G01R33/56563—Correction of image distortions, e.g. due to magnetic field inhomogeneities caused by a distortion of the main magnetic field B0, e.g. temporal variation of the magnitude or spatial inhomogeneity of B0
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/445—MR involving a non-standard magnetic field B0, e.g. of low magnitude as in the earth's magnetic field or in nanoTesla spectroscopy, comprising a polarizing magnetic field for pre-polarisation, B0 with a temporal variation of its magnitude or direction such as field cycling of B0 or rotation of the direction of B0, or spatially inhomogeneous B0 like in fringe-field MR or in stray-field imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/561—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences
    • G01R33/5615—Echo train techniques involving acquiring plural, differently encoded, echo signals after one RF excitation, e.g. using gradient refocusing in echo planar imaging [EPI], RF refocusing in rapid acquisition with relaxation enhancement [RARE] or using both RF and gradient refocusing in gradient and spin echo imaging [GRASE]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/58—Calibration of imaging systems, e.g. using test probes, Phantoms; Calibration objects or fiducial markers such as active or passive RF coils surrounding an MR active material

Landscapes

  • Physics & Mathematics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Signal Processing (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

L'invention porte sur un procédé d'extraction d'un spectre de RMN d'un échantillon en cours d'étude. Ledit procédé consiste: à soumettre à la fois l'échantillon et un échantillon de référence: à un champ magnétique statique non homogène, à une ou plusieurs impulsions RF, et à un ou des gradients de champ magnétique, pour acquérir des signaux de sous-échantillon de RMN d'au moins deux régions de l'échantillon à l'étude et de l'échantillon de référence; à déconvolutionner les signaux des sous-échantillons de RMN provenant des régions de l'échantillon à l'étude et des régions correspondantes de l'échantillon de référence, pour obtenir un signal déconvolutionné pour chacune de ces régions; et à totaliser les signaux déconvolutionnés de chaque région pour obtenir le spectre RMN de l'échantillon à l'étude. L'invention porte également sur des procédés et des systèmes associés d'extraction de spectres de RMN.
PCT/NZ2007/000287 2006-10-03 2007-10-03 Procédé d'extraction de spectre de rmn WO2008041866A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2007302889A AU2007302889A1 (en) 2006-10-03 2007-10-03 NMR spectra extraction method

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NZ550298 2006-10-03
NZ55029806A NZ550298A (en) 2006-10-03 2006-10-03 NMR spectra extraction method

Publications (2)

Publication Number Publication Date
WO2008041866A2 WO2008041866A2 (fr) 2008-04-10
WO2008041866A3 true WO2008041866A3 (fr) 2008-05-22

Family

ID=39268903

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NZ2007/000287 WO2008041866A2 (fr) 2006-10-03 2007-10-03 Procédé d'extraction de spectre de rmn

Country Status (3)

Country Link
AU (1) AU2007302889A1 (fr)
NZ (1) NZ550298A (fr)
WO (1) WO2008041866A2 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4528509A (en) * 1981-09-09 1985-07-09 National Research Development Corporation Spatially selective NMR
EP0495405A1 (fr) * 1991-01-17 1992-07-22 Bruker Instruments, Inc. Procédé pour augmenter la résolution dans un système d'imagerie de solides par RMN

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4528509A (en) * 1981-09-09 1985-07-09 National Research Development Corporation Spatially selective NMR
EP0495405A1 (fr) * 1991-01-17 1992-07-22 Bruker Instruments, Inc. Procédé pour augmenter la résolution dans un système d'imagerie de solides par RMN
US5327085A (en) * 1991-01-17 1994-07-05 Bruker Instruments, Inc. Method for increasing resolution in a NMR solids imaging system

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LI ET AL.: "Spectral restoration from low signal-to-noise, distorted NMR signals: application to hyphenated capillary electrophoresis-NMR", JOURNAL OF MAGNETIC RESONANCE, vol. 162, 2003, pages 133 - 140, XP004425311, DOI: doi:10.1016/S1090-7807(03)00055-7 *
METZ ET AL.: "Reference Deconvolution: A Simple and Effective method for Resolution Enhancement in Nuclear Resonance Spectroscopy", CONCEPTS IN MAGNETIC RESONANCE, vol. 12, no. 1, 2000, pages 21 - 42 *

Also Published As

Publication number Publication date
AU2007302889A1 (en) 2008-04-10
WO2008041866A2 (fr) 2008-04-10
NZ550298A (en) 2009-05-31

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