WO2008041244A3 - A method for the identification of potential biomarkers and drug targets in brain plasticity related disorders - Google Patents
A method for the identification of potential biomarkers and drug targets in brain plasticity related disorders Download PDFInfo
- Publication number
- WO2008041244A3 WO2008041244A3 PCT/IN2007/000452 IN2007000452W WO2008041244A3 WO 2008041244 A3 WO2008041244 A3 WO 2008041244A3 IN 2007000452 W IN2007000452 W IN 2007000452W WO 2008041244 A3 WO2008041244 A3 WO 2008041244A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- related disorders
- drug targets
- potential biomarkers
- identification
- brain plasticity
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
The invention relates to identification of potential biomarkers and drug targets in brain plasticity related disorders. In particular, the invention describes a system level model of brain plasticity related disorders in the fruit fly Drosophila melanogaster, thereby identifying potential biomarkers and drug targets in epileptogenesis and associated conditions. The invention also provides a means of screening therapeutic agents against epilepsy and related disorders using gene expression profiling in Drosophila.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07827592A EP2076608A2 (en) | 2006-10-05 | 2007-10-01 | A method for the identification of potential biomarkers and drug targets in brain plasticity related disorders |
NO20091627A NO20091627L (en) | 2006-10-05 | 2009-04-23 | Procedure for Identifying Potential Biomarkers and Drug Templates in Brain Plasticity-Related Disorders |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2193DE2006 | 2006-10-05 | ||
IN2193/DEL/2006 | 2006-10-05 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2008041244A2 WO2008041244A2 (en) | 2008-04-10 |
WO2008041244A3 true WO2008041244A3 (en) | 2008-07-31 |
WO2008041244B1 WO2008041244B1 (en) | 2008-10-09 |
Family
ID=39198212
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2007/000452 WO2008041244A2 (en) | 2006-10-05 | 2007-10-01 | A method for the identification of potential biomarkers and drug targets in brain plasticity related disorders |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP2076608A2 (en) |
NO (1) | NO20091627L (en) |
WO (1) | WO2008041244A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108977549B (en) * | 2018-07-04 | 2021-01-15 | 中国农业大学 | Primer pair for detecting expression quantity of CG5210 gene of fruit fly |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6291739B1 (en) * | 2000-03-24 | 2001-09-18 | Council Of Scientific And Industrial Research | Method for screening of potential anti-epileptic drugs using a Drosophila melanogaster model |
-
2007
- 2007-10-01 EP EP07827592A patent/EP2076608A2/en not_active Withdrawn
- 2007-10-01 WO PCT/IN2007/000452 patent/WO2008041244A2/en active Application Filing
-
2009
- 2009-04-23 NO NO20091627A patent/NO20091627L/en not_active Application Discontinuation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6291739B1 (en) * | 2000-03-24 | 2001-09-18 | Council Of Scientific And Industrial Research | Method for screening of potential anti-epileptic drugs using a Drosophila melanogaster model |
Non-Patent Citations (9)
Title |
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CEPELAK I ET AL: "Valproate and carbamazepine comedication changes hepatic enzyme activities in sera of epileptic children", CLINICA CHIMICA ACTA 19980828 NL, vol. 276, no. 2, 28 August 1998 (1998-08-28), pages 121 - 127, XP002477701, ISSN: 0009-8981 * |
GU J ET AL: "The antiepileptic drug levetiracetam selectively modifies kindling-induced alterations in gene expression in the temporal lobe of rats", EUROPEAN JOURNAL OF NEUROSCIENCE, OXFORD UNIVERSITY PRESS, GB, vol. 19, no. 2, January 2004 (2004-01-01), pages 334 - 345, XP002324334, ISSN: 0953-816X * |
HASSEL BJORNAR ET AL: "Changes in gene expression suggest new mechanisms of long-term valproate treatment.", EPILEPSIA, vol. 44, no. Supplement 9, 2003, & ANNUAL MEETING OF THE AMERICAN EPILEPSY SOCIETY; BOSTON, MA, USA; DECEMBER 05-10, 2003, pages 338 - 339, XP009099234, ISSN: 0013-9580 * |
JEONG M R ET AL: "Profiles of valproate - regulated gene expression in mouse brain.", SOCIETY FOR NEUROSCIENCE ABSTRACT VIEWER AND ITINERARY PLANNER, vol. 2003, 2003, & 33RD ANNUAL MEETING OF THE SOCIETY OF NEUROSCIENCE; NEW ORLEANS, LA, USA; NOVEMBER 08-12, 2003, pages Abstract No. 850.3 URL - http://sf, XP009099218 * |
KIM SEUNG-KI ET AL: "Gene expression profile analyses of cortical dysplasia by cDNA arrays.", EPILEPSY RESEARCH, vol. 56, no. 2-3, October 2003 (2003-10-01), pages 175 - 183, XP002477728, ISSN: 0920-1211 * |
KUEBLER DANIEL ET AL: "Anticonvulsant valproate reduces seizure-susceptibility in mutant Drosophila.", BRAIN RESEARCH, vol. 958, no. 1, 20 December 2002 (2002-12-20), pages 36 - 42, XP002477727, ISSN: 0006-8993 * |
KUMAR KIRAN ET AL: "Erythrocyte glutathione and serum total glutathione-S-transferase in epilepsy.", CLINICAL CHEMISTRY AND LABORATORY MEDICINE : CCLM / FESCC 2005, vol. 43, no. 1, 2005, pages 106 - 107, XP009099236, ISSN: 1434-6621 * |
STILWELL GEOFF E ET AL: "Development of a Drosophila seizure model for in vivo high-throughput drug screening", EUROPEAN JOURNAL OF NEUROSCIENCE, vol. 24, no. 8, October 2006 (2006-10-01), pages 2211 - 2222, XP002477726, ISSN: 0953-816X * |
ZUSTERZEEL PETRA L M ET AL: "Glutathione S-transferase alpha levels in epileptic and healthy women preconceptionally and throughout pregnancy", GYNECOLOGIC AND OBSTETRIC INVESTIGATION, vol. 48, no. 2, August 1999 (1999-08-01), pages 89 - 92, XP009099237, ISSN: 0378-7346 * |
Also Published As
Publication number | Publication date |
---|---|
NO20091627L (en) | 2009-07-02 |
WO2008041244A2 (en) | 2008-04-10 |
WO2008041244B1 (en) | 2008-10-09 |
EP2076608A2 (en) | 2009-07-08 |
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