WO2008038143A3 - Novel solid forms of rimonabant and synthetic processes for their preparation - Google Patents

Novel solid forms of rimonabant and synthetic processes for their preparation Download PDF

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Publication number
WO2008038143A3
WO2008038143A3 PCT/IB2007/003678 IB2007003678W WO2008038143A3 WO 2008038143 A3 WO2008038143 A3 WO 2008038143A3 IB 2007003678 W IB2007003678 W IB 2007003678W WO 2008038143 A3 WO2008038143 A3 WO 2008038143A3
Authority
WO
WIPO (PCT)
Prior art keywords
rimonabant
preparation
solid forms
synthetic processes
novel solid
Prior art date
Application number
PCT/IB2007/003678
Other languages
French (fr)
Other versions
WO2008038143A2 (en
Inventor
Velez Monica Benito
Stephen Winter
Original Assignee
Medichem Sa
Velez Monica Benito
Stephen Winter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem Sa, Velez Monica Benito, Stephen Winter filed Critical Medichem Sa
Publication of WO2008038143A2 publication Critical patent/WO2008038143A2/en
Publication of WO2008038143A3 publication Critical patent/WO2008038143A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Abstract

The invention relates to novel solid forms of rimonabant and amorphous rimonabant and synthetic processes for their preparation.
PCT/IB2007/003678 2006-06-22 2007-06-22 Novel solid forms of rimonabant and synthetic processes for their preparation WO2008038143A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81556406P 2006-06-22 2006-06-22
US60/815,564 2006-06-22

Publications (2)

Publication Number Publication Date
WO2008038143A2 WO2008038143A2 (en) 2008-04-03
WO2008038143A3 true WO2008038143A3 (en) 2009-02-19

Family

ID=39230601

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/003678 WO2008038143A2 (en) 2006-06-22 2007-06-22 Novel solid forms of rimonabant and synthetic processes for their preparation

Country Status (2)

Country Link
AR (1) AR061606A1 (en)
WO (1) WO2008038143A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008026219A2 (en) * 2006-09-01 2008-03-06 Hetero Drugs Limited Novel polymorphs of rimonabant
WO2008064615A2 (en) * 2006-12-01 2008-06-05 Zentiva, A.S. Crystalline and amorphous forms of rimonabant and processes for obtaining them
US20080182877A1 (en) * 2007-01-05 2008-07-31 Westheim Raymond J H Rimonabant forms and methods of making the same

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0656354A1 (en) * 1993-12-02 1995-06-07 Sanofi Substituted N-piperidino 3-pyrazolecarboxamide
US5624941A (en) * 1992-06-23 1997-04-29 Sanofi Pyrazole derivatives, method of preparing them and pharmaceutical compositions in which they are present
WO2002028346A2 (en) * 2000-10-04 2002-04-11 Aventis Pharma S.A. Association of the cb1 receptor antagonist and sibutramin, for treating obesity
US20050043356A1 (en) * 2001-11-08 2005-02-24 Alain Alcade Polymorphic form of rimonabant method for preparing it and pharmaceutical compositions containing it
EP1816125A1 (en) * 2006-02-02 2007-08-08 Ranbaxy Laboratories, Ltd. Novel crystalline forms of an antagonist of CB1 cannabinoid receptor and preparation method thereof
WO2008026219A2 (en) * 2006-09-01 2008-03-06 Hetero Drugs Limited Novel polymorphs of rimonabant
EP1953144A1 (en) * 2007-01-30 2008-08-06 Sandoz AG Novel polymorphic forms of N-piperidino-5-(4-chlorophenyl)-1-(2, 4-dichlorphenyl)-4-methyl-3-pyrazolecarboxamide

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5624941A (en) * 1992-06-23 1997-04-29 Sanofi Pyrazole derivatives, method of preparing them and pharmaceutical compositions in which they are present
EP0656354A1 (en) * 1993-12-02 1995-06-07 Sanofi Substituted N-piperidino 3-pyrazolecarboxamide
WO2002028346A2 (en) * 2000-10-04 2002-04-11 Aventis Pharma S.A. Association of the cb1 receptor antagonist and sibutramin, for treating obesity
US20050043356A1 (en) * 2001-11-08 2005-02-24 Alain Alcade Polymorphic form of rimonabant method for preparing it and pharmaceutical compositions containing it
EP1816125A1 (en) * 2006-02-02 2007-08-08 Ranbaxy Laboratories, Ltd. Novel crystalline forms of an antagonist of CB1 cannabinoid receptor and preparation method thereof
WO2008026219A2 (en) * 2006-09-01 2008-03-06 Hetero Drugs Limited Novel polymorphs of rimonabant
EP1953144A1 (en) * 2007-01-30 2008-08-06 Sandoz AG Novel polymorphic forms of N-piperidino-5-(4-chlorophenyl)-1-(2, 4-dichlorphenyl)-4-methyl-3-pyrazolecarboxamide

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SELTZMAN HERBERT H ET AL: "Tritiation of SR141716 by metalation-iodination-reduction: tritium-proton noe study", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, JOHN WILEY, CHICHESTER, GB, vol. 45, 1 January 2002 (2002-01-01), pages 59 - 70, XP002432372, ISSN: 0362-4803 *

Also Published As

Publication number Publication date
WO2008038143A2 (en) 2008-04-03
AR061606A1 (en) 2008-09-10

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