WO2008033455A3 - Biphenyl and heteroaryl phenyl derivatives as protein tyrosine phosphatases inhibitors - Google Patents

Biphenyl and heteroaryl phenyl derivatives as protein tyrosine phosphatases inhibitors Download PDF

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Publication number
WO2008033455A3
WO2008033455A3 PCT/US2007/019915 US2007019915W WO2008033455A3 WO 2008033455 A3 WO2008033455 A3 WO 2008033455A3 US 2007019915 W US2007019915 W US 2007019915W WO 2008033455 A3 WO2008033455 A3 WO 2008033455A3
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protein tyrosine
compounds
biphenyl
tyrosine phosphatases
phenyl derivatives
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PCT/US2007/019915
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French (fr)
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WO2008033455A2 (en
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Zandt Michael C Van
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Inst For Pharm Discovery Inc
Zandt Michael C Van
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Publication of WO2008033455A2 publication Critical patent/WO2008033455A2/en
Publication of WO2008033455A3 publication Critical patent/WO2008033455A3/en

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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
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    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Disclosed are compounds and pharmaceutically acceptable salts of formula (I) : wherein A, B, D, L1 L2, R2, RA, RB, X, m, n, and p are as defined herein, which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
PCT/US2007/019915 2006-09-13 2007-09-13 Biphenyl and heteroaryl phenyl derivatives as protein tyrosine phosphatases inhibitors WO2008033455A2 (en)

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