WO2008030807A3 - Phosphatidylethanolamine derivative and liposome containing the same - Google Patents

Phosphatidylethanolamine derivative and liposome containing the same Download PDF

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Publication number
WO2008030807A3
WO2008030807A3 PCT/US2007/077537 US2007077537W WO2008030807A3 WO 2008030807 A3 WO2008030807 A3 WO 2008030807A3 US 2007077537 W US2007077537 W US 2007077537W WO 2008030807 A3 WO2008030807 A3 WO 2008030807A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
target cell
group
same
phosphatidylethanolamine derivative
Prior art date
Application number
PCT/US2007/077537
Other languages
French (fr)
Other versions
WO2008030807A2 (en
Inventor
Kazushi Okada
Naoyuki Morisaki
Yusuke Miyajima
Original Assignee
Mebiopharm Co Ltd
Kazushi Okada
Naoyuki Morisaki
Yusuke Miyajima
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mebiopharm Co Ltd, Kazushi Okada, Naoyuki Morisaki, Yusuke Miyajima filed Critical Mebiopharm Co Ltd
Publication of WO2008030807A2 publication Critical patent/WO2008030807A2/en
Publication of WO2008030807A3 publication Critical patent/WO2008030807A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids

Abstract

The present invention provides a liposome preparation having high efficiency of delivery of a drug into a target cell, which exhibits such an appropriate retention in blood as to allow the pharmaceutical preparation to be incorporated into a target cell but not such a long time as to induce its side effects on normal cells, as well as a novel synthetic phospholipid useful in preparation of the liposome preparation. Disclosed is a phosphatidylethanolamine derivative represented by the following general formula (1), or salts thereof: wherein X represents -0-, -NH- or -S-, R1 represents an alkyl group, a cycloalkyl group or an aryl group, R2 and R3 independently represent an acyl group, and m represents an integer of 1 to 10.
PCT/US2007/077537 2006-09-05 2007-09-04 Phosphatidylethanolamine derivative and liposome containing the same WO2008030807A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84258906P 2006-09-05 2006-09-05
US60/842,589 2006-09-05

Publications (2)

Publication Number Publication Date
WO2008030807A2 WO2008030807A2 (en) 2008-03-13
WO2008030807A3 true WO2008030807A3 (en) 2008-11-13

Family

ID=39157976

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/077537 WO2008030807A2 (en) 2006-09-05 2007-09-04 Phosphatidylethanolamine derivative and liposome containing the same

Country Status (1)

Country Link
WO (1) WO2008030807A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3769789A1 (en) * 2012-08-01 2021-01-27 Nationwide Children's Hospital Intrathecal delivery of recombinant adeno-associated virus 9
CN113307824B (en) * 2021-04-26 2022-05-27 浙江大学 Amphiphilic material and application thereof in preparation of liposome

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751219A (en) * 1985-02-05 1988-06-14 Nederlandse Centrale Organisatie Voor Toegepast-Natuur-Wetenschappelijk Onderzoek Synthetic glycolipides, a process for the preparation thereof and several uses for these synthetic glycolipides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751219A (en) * 1985-02-05 1988-06-14 Nederlandse Centrale Organisatie Voor Toegepast-Natuur-Wetenschappelijk Onderzoek Synthetic glycolipides, a process for the preparation thereof and several uses for these synthetic glycolipides

Also Published As

Publication number Publication date
WO2008030807A2 (en) 2008-03-13

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