WO2008030771A8 - Composés d'alkylidène cycliques en tant que modulateurs sélectifs des récepteurs des œstrogènes - Google Patents

Composés d'alkylidène cycliques en tant que modulateurs sélectifs des récepteurs des œstrogènes

Info

Publication number
WO2008030771A8
WO2008030771A8 PCT/US2007/077356 US2007077356W WO2008030771A8 WO 2008030771 A8 WO2008030771 A8 WO 2008030771A8 US 2007077356 W US2007077356 W US 2007077356W WO 2008030771 A8 WO2008030771 A8 WO 2008030771A8
Authority
WO
WIPO (PCT)
Prior art keywords
estrogen receptor
selective estrogen
receptor modulators
cyclic alkylidene
compounds
Prior art date
Application number
PCT/US2007/077356
Other languages
English (en)
Other versions
WO2008030771A1 (fr
Inventor
William John Zuercher
Dennis Heyer
Aaron Bayne Miller
Original Assignee
Smithkline Beecham Corp
William John Zuercher
Dennis Heyer
Aaron Bayne Miller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp, William John Zuercher, Dennis Heyer, Aaron Bayne Miller filed Critical Smithkline Beecham Corp
Publication of WO2008030771A1 publication Critical patent/WO2008030771A1/fr
Publication of WO2008030771A8 publication Critical patent/WO2008030771A8/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention concerne de nouveaux composés ayant diverses utilisations thérapeutiques, plus particulièrement de nouveaux composés d'alkylidène cycliques substitués qui sont particulièrement utiles pour la modulation sélective des récepteurs des œstrogènes.
PCT/US2007/077356 2006-09-08 2007-08-31 Composés d'alkylidène cycliques en tant que modulateurs sélectifs des récepteurs des œstrogènes WO2008030771A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82492006P 2006-09-08 2006-09-08
US60/824,920 2006-09-08

Publications (2)

Publication Number Publication Date
WO2008030771A1 WO2008030771A1 (fr) 2008-03-13
WO2008030771A8 true WO2008030771A8 (fr) 2008-05-15

Family

ID=38983569

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/077356 WO2008030771A1 (fr) 2006-09-08 2007-08-31 Composés d'alkylidène cycliques en tant que modulateurs sélectifs des récepteurs des œstrogènes

Country Status (1)

Country Link
WO (1) WO2008030771A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102786394B (zh) * 2012-07-30 2017-03-01 中国医学科学院医药生物技术研究所 取代双芳基亚甲基环烷基衍生物及其制备方法和应用
EP3266771B1 (fr) 2016-06-10 2019-02-20 Paris Sciences Et Lettres - Quartier Latin Synthèse de cyclofen-oh en cage photoactivable et ses dérivés

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7560589B2 (en) * 2003-07-28 2009-07-14 Smithkline Beecham Corporation Cycloalkylidene compounds as modulators of estrogen receptor

Also Published As

Publication number Publication date
WO2008030771A1 (fr) 2008-03-13

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