WO2008024423A3 - 4-thio substituted quinoline and naphthyridine compounds - Google Patents

4-thio substituted quinoline and naphthyridine compounds Download PDF

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Publication number
WO2008024423A3
WO2008024423A3 PCT/US2007/018607 US2007018607W WO2008024423A3 WO 2008024423 A3 WO2008024423 A3 WO 2008024423A3 US 2007018607 W US2007018607 W US 2007018607W WO 2008024423 A3 WO2008024423 A3 WO 2008024423A3
Authority
WO
WIPO (PCT)
Prior art keywords
substituted quinoline
thio substituted
naphthyridine compounds
naphthyridine
thio
Prior art date
Application number
PCT/US2007/018607
Other languages
French (fr)
Other versions
WO2008024423A2 (en
Inventor
Zhen Yang
Reza Fathi
Qiang Zhu
Hyun Joon Cho
Yixin Liu
Anthony Sandrasagra
Richard C Wobbe
Original Assignee
Xtl Biopharmaceuticals Ltd
Zhen Yang
Reza Fathi
Qiang Zhu
Hyun Joon Cho
Yixin Liu
Anthony Sandrasagra
Richard C Wobbe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xtl Biopharmaceuticals Ltd, Zhen Yang, Reza Fathi, Qiang Zhu, Hyun Joon Cho, Yixin Liu, Anthony Sandrasagra, Richard C Wobbe filed Critical Xtl Biopharmaceuticals Ltd
Priority to EP07837234A priority Critical patent/EP2061466A4/en
Priority to CA002677001A priority patent/CA2677001A1/en
Priority to AU2007288188A priority patent/AU2007288188A1/en
Priority to JP2009525625A priority patent/JP2010501570A/en
Publication of WO2008024423A2 publication Critical patent/WO2008024423A2/en
Publication of WO2008024423A3 publication Critical patent/WO2008024423A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

The present invention relates to 4-thio substituted quinoline and naphthyridine derivatives and processes for their preparation. The invention also related to methods for treating infection of Hepatitis C virus by administering a 4-thio substituted quinoline or naphthyridine derivative.
PCT/US2007/018607 2006-08-23 2007-08-22 4-thio substituted quinoline and naphthyridine compounds WO2008024423A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP07837234A EP2061466A4 (en) 2006-08-23 2007-08-22 4-thio substituted quinoline and naphthyridine compounds
CA002677001A CA2677001A1 (en) 2006-08-23 2007-08-22 4-thio substituted quinoline and naphthyridine compounds
AU2007288188A AU2007288188A1 (en) 2006-08-23 2007-08-22 4-thio substituted quinoline and naphthyridine compounds
JP2009525625A JP2010501570A (en) 2006-08-23 2007-08-22 4-thio-substituted quinoline and naphthyridine compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83992206P 2006-08-23 2006-08-23
US60/839,922 2006-08-23

Publications (2)

Publication Number Publication Date
WO2008024423A2 WO2008024423A2 (en) 2008-02-28
WO2008024423A3 true WO2008024423A3 (en) 2008-11-20

Family

ID=39107397

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/018607 WO2008024423A2 (en) 2006-08-23 2007-08-22 4-thio substituted quinoline and naphthyridine compounds

Country Status (5)

Country Link
EP (1) EP2061466A4 (en)
JP (1) JP2010501570A (en)
AU (1) AU2007288188A1 (en)
CA (1) CA2677001A1 (en)
WO (1) WO2008024423A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3359526A4 (en) 2015-10-05 2019-04-03 The Trustees of Columbia University in the City of New York Activators of autophagic flux and phospholipase d and clearance of protein aggregates including tau and treatment of proteinopathies
US11459340B2 (en) 2018-09-18 2022-10-04 Nikang Therapeutics, Inc. Tri-substituted heteroaryl derivatives as Src homology-2 phosphatase inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430153A (en) * 1991-04-03 1995-07-04 Korea Research Institute Of Chemical Technology 2-quinolinone derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2737496B1 (en) * 1995-07-31 1997-12-19 Centre Nat Rech Scient 4-ARYL-THIO-PYRIDIN-2 (1H) -ONES, MEDICAMENTS CONTAINING THEM, AND USES THEREOF IN THE TREATMENT OF HIV-1 AND 2-RELATED DISEASES
CN1829709A (en) * 2003-08-01 2006-09-06 健亚生物科技公司 Bicyclic imidazol derivatives against flaviviridae

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430153A (en) * 1991-04-03 1995-07-04 Korea Research Institute Of Chemical Technology 2-quinolinone derivatives

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HOPKINS ET AL.: "Desigh of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase with Improved Drug Resistance Properties.", I. J MED. CHEM., vol. 47, 2004, pages 5912 - 5922, XP008104520 *
See also references of EP2061466A4 *

Also Published As

Publication number Publication date
EP2061466A2 (en) 2009-05-27
JP2010501570A (en) 2010-01-21
CA2677001A1 (en) 2008-02-28
AU2007288188A1 (en) 2008-02-28
WO2008024423A2 (en) 2008-02-28
EP2061466A4 (en) 2010-12-29

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