WO2008024195A3 - Methods and compositions for conserving and/or preparing an organ or tissue for transplant - Google Patents

Methods and compositions for conserving and/or preparing an organ or tissue for transplant Download PDF

Info

Publication number
WO2008024195A3
WO2008024195A3 PCT/US2007/017483 US2007017483W WO2008024195A3 WO 2008024195 A3 WO2008024195 A3 WO 2008024195A3 US 2007017483 W US2007017483 W US 2007017483W WO 2008024195 A3 WO2008024195 A3 WO 2008024195A3
Authority
WO
WIPO (PCT)
Prior art keywords
organ
tissue
conservative variant
variant
biological activity
Prior art date
Application number
PCT/US2007/017483
Other languages
French (fr)
Other versions
WO2008024195A2 (en
Inventor
Jack Finkelstein Jr
C Neil Lyons
Original Assignee
Regenerx Biopharmaceuticals
Jack Finkelstein Jr
C Neil Lyons
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regenerx Biopharmaceuticals, Jack Finkelstein Jr, C Neil Lyons filed Critical Regenerx Biopharmaceuticals
Priority to JP2009524618A priority Critical patent/JP2010501486A/en
Priority to EP07836540A priority patent/EP2061491A2/en
Priority to US12/377,939 priority patent/US20100278934A1/en
Priority to CA002660928A priority patent/CA2660928A1/en
Priority to MX2009001702A priority patent/MX2009001702A/en
Priority to AU2007288410A priority patent/AU2007288410A1/en
Publication of WO2008024195A2 publication Critical patent/WO2008024195A2/en
Publication of WO2008024195A3 publication Critical patent/WO2008024195A3/en
Priority to IL196995A priority patent/IL196995A0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K4/00—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Physiology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

A method of conserving and/or preparing an organ or tissue for transplant for a subject, includes administering to a subject, organ or tissue in need of such treatment an effective amount of a composition including a polypeptide agent including thymosin beta 4 (TB4), an isoform, analogue or derivative of TB4 having biological activity of TB4, an N-terminal variant of TB4 having biological activity of TB4, a C-terminal variant of TB4 having biological activity of TB4, LKKTET or a conservative variant thereof, LKKTNT or a conservative variant thereof, KLKKTET or a conservative variant thereof, LKKTETQ or a conservative variant thereof, TB4 sulfoxide, TB4ala, TB9, TBIO, TB11, TB12, TB13, TB14, TB15, gelsolin, vitamin D binding protein (DBP), profilin, cofilin, adsevertin, propomyosin, fincilin, depactin, Dnasel, vilin, fragmin, severin, capping protein, ?-actinin or acumentin, or a stimulating agent that stimulates production of a polypeptide agent as described above, or a conservative variant thereof, in the organ or tissue.
PCT/US2007/017483 2006-08-18 2007-08-06 Methods and compositions for conserving and/or preparing an organ or tissue for transplant WO2008024195A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2009524618A JP2010501486A (en) 2006-08-18 2007-08-06 Methods and compositions for storing and / or preparing organs or tissues for transplantation
EP07836540A EP2061491A2 (en) 2006-08-18 2007-08-06 Methods and compositions for conserving and/or preparing an organ or tissue for transplant
US12/377,939 US20100278934A1 (en) 2006-08-18 2007-08-06 Methods and compositions for conserving and/or preparing an organ or tissue for transplant
CA002660928A CA2660928A1 (en) 2006-08-18 2007-08-06 Methods and compositions for conserving and/or preparing an organ or tissue for transplant
MX2009001702A MX2009001702A (en) 2006-08-18 2007-08-06 Methods and compositions for conserving and/or preparing an organ or tissue for transplant.
AU2007288410A AU2007288410A1 (en) 2006-08-18 2007-08-06 Methods and compositions for conserving and/or preparing an organ or tissue for transplant
IL196995A IL196995A0 (en) 2006-08-18 2009-02-11 Methods and compositions for conserving and/or preparing an organ or tissue for transplant

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83838306P 2006-08-18 2006-08-18
US60/838,383 2006-08-18

Publications (2)

Publication Number Publication Date
WO2008024195A2 WO2008024195A2 (en) 2008-02-28
WO2008024195A3 true WO2008024195A3 (en) 2008-07-17

Family

ID=39107280

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/017483 WO2008024195A2 (en) 2006-08-18 2007-08-06 Methods and compositions for conserving and/or preparing an organ or tissue for transplant

Country Status (10)

Country Link
US (1) US20100278934A1 (en)
EP (1) EP2061491A2 (en)
JP (1) JP2010501486A (en)
KR (1) KR20090049605A (en)
CN (1) CN101505782A (en)
AU (1) AU2007288410A1 (en)
CA (1) CA2660928A1 (en)
IL (1) IL196995A0 (en)
MX (1) MX2009001702A (en)
WO (1) WO2008024195A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014160989A2 (en) 2013-03-28 2014-10-02 The Trustees Of Columbia University In The City Of New York Reperfusion with omega-3 glycerides promotes donor organ protection for transplantation
US20130323708A1 (en) 2009-07-01 2013-12-05 Massachusetts Institute Of Technology Isolated adult cells, artificial organs, rehabilitated organs, research tools, organ encasements, organ perfusion systems, and methods for preparing and utilizing the same
SE534527C2 (en) * 2009-09-24 2011-09-20 Vivoline Medical Ab Procedure, device and fluid for treating a heart after withdrawal
WO2011140241A2 (en) * 2010-05-04 2011-11-10 The General Hospital Corporation Methods and compositions for preserving tissues and organs
US10918102B2 (en) 2014-03-13 2021-02-16 The General Hospital Corporation Devices and methods to improve and assess viability of human livers
EP3982999A4 (en) * 2019-06-17 2023-07-19 Trim-Edicine, Inc. Composition for and method of treating hepatic tissue injury

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4879109A (en) * 1986-05-15 1989-11-07 Emory University Method for treating burns
WO2000006190A1 (en) * 1998-07-30 2000-02-10 The Government Of The United States Of America, As Represented By The Secretary Of Health And Human Services, National Institutes Of Health THYMOSIN β4 PROMOTES WOUND REPAIR
WO2005027958A1 (en) * 2003-09-19 2005-03-31 Imperial College Innovations Ltd Thymosin-beta-sulphoxide as an immunosuppressive active agent

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080051348A1 (en) * 2002-02-06 2008-02-28 Regenerx Biopharmaceuticals, Inc. Treatment of infections and other disorders

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4879109A (en) * 1986-05-15 1989-11-07 Emory University Method for treating burns
WO2000006190A1 (en) * 1998-07-30 2000-02-10 The Government Of The United States Of America, As Represented By The Secretary Of Health And Human Services, National Institutes Of Health THYMOSIN β4 PROMOTES WOUND REPAIR
WO2005027958A1 (en) * 2003-09-19 2005-03-31 Imperial College Innovations Ltd Thymosin-beta-sulphoxide as an immunosuppressive active agent

Also Published As

Publication number Publication date
IL196995A0 (en) 2009-11-18
JP2010501486A (en) 2010-01-21
EP2061491A2 (en) 2009-05-27
MX2009001702A (en) 2009-03-26
WO2008024195A2 (en) 2008-02-28
US20100278934A1 (en) 2010-11-04
AU2007288410A1 (en) 2008-02-28
KR20090049605A (en) 2009-05-18
CA2660928A1 (en) 2008-02-28
CN101505782A (en) 2009-08-12

Similar Documents

Publication Publication Date Title
WO2008024195A3 (en) Methods and compositions for conserving and/or preparing an organ or tissue for transplant
EP2200427B1 (en) Use of neuregulin for organ preservation
King et al. Amino acid utilization in seeds of loblolly pine during germination and early seedling growth (I. arginine and arginase activity)
RU2007106075A (en) COMPOSITIONS AND METHODS OF APPLICATION OF ANGIOPOETIN-LIKE PROTEIN 4
JP2008543878A5 (en)
WO2006113681A3 (en) Plant-derived elastin binding protein ligands and methods of using the same
WO2006138708B1 (en) Lkktet and/or lkktnt peptide compositions which are lyophilized or in a form capable of being lyophilized
Lomonte et al. Snake venomics and toxicological profiling of the arboreal pitviper Bothriechis supraciliaris from Costa Rica
DE602006020562D1 (en) HREN FOR THIS
STEFFENS et al. The primary structure of Cu-Zn superoxide dismutase from Photobacterium leiognathi: evidence for a separate evolution of Cu-Zn superoxide dismutase in bacteria
ES2846758T3 (en) Methods to remove alpha-galactose
WO2006057674A3 (en) COMPOSITIONS AND METHODS FOR EX VIVO PRESERVATION OF BLOOD VESSELS FOR VASCULAR GRAFTS USING ANALOGUES OF cAMP AND cGMP
KR102497637B1 (en) A mixture of purified SODs of plant origin
Drucker et al. Collagen stable isotopes provide insights into the end of the mammoth steppe in the central East European plains during the Epigravettian
Kage et al. Rabbit neuromedin U-25: lack of conservation of a posttranslational processing site
Matsuda et al. Isolation and structural characterization of pituitary adenylate cyclase activating polypeptide (PACAP)-like peptide from the brain of a teleost, stargazer, Uranoscopus japonicus
WO2008024194A3 (en) Method of conserving and preparing tissue or cells for transfer, transplant, re-implantation, further study or the like
EP3052121B1 (en) Wnt compositions and methods for purification
Philippou et al. Characterization of a rabbit antihuman mechano growth factor (MGF) polyclonal antibody against the last 24 amino acids of the E domain
WO2008045345A3 (en) Method of treating or preventing tissue deterioration, injury or damage due to periodontal disease or disease of oral mucosa, and/or downregulating nf-kappab or suppressing nf-kappab-mediated actions
CY1106954T1 (en) LIQUID erythropoietin formulation
Svyatko Stable isotope analysis: outline of methodology, and a review of studies in Siberia and the Eurasian Steppe
O’Harte et al. Structure, antihyperglycemic activity and cellular actions of a novel diglycated human insulin
Rayne et al. Reconstitution of adipokinetic hormone biosynthesis in vitro indicates steps in prohormone processing
Rodriguez-Bello et al. Purification and primary structure of alligator neurotensin

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200780030786.X

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07836540

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 196995

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: MX/A/2009/001702

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 2660928

Country of ref document: CA

Ref document number: 2009524618

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 12377939

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2007288410

Country of ref document: AU

Ref document number: 954/KOLNP/2009

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 2007836540

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 1020097005480

Country of ref document: KR

NENP Non-entry into the national phase

Ref country code: RU

ENP Entry into the national phase

Ref document number: 2007288410

Country of ref document: AU

Date of ref document: 20070806

Kind code of ref document: A