WO2008024194A3 - Method of conserving and preparing tissue or cells for transfer, transplant, re-implantation, further study or the like - Google Patents

Method of conserving and preparing tissue or cells for transfer, transplant, re-implantation, further study or the like Download PDF

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Publication number
WO2008024194A3
WO2008024194A3 PCT/US2007/017482 US2007017482W WO2008024194A3 WO 2008024194 A3 WO2008024194 A3 WO 2008024194A3 US 2007017482 W US2007017482 W US 2007017482W WO 2008024194 A3 WO2008024194 A3 WO 2008024194A3
Authority
WO
WIPO (PCT)
Prior art keywords
cells
tissue
conservative variant
variant
biological activity
Prior art date
Application number
PCT/US2007/017482
Other languages
French (fr)
Other versions
WO2008024194A2 (en
Inventor
Jr Jack Finkelstein
C Neil Lyons
Original Assignee
Regenerx Biopharmaceuticals
Jr Jack Finkelstein
C Neil Lyons
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regenerx Biopharmaceuticals, Jr Jack Finkelstein, C Neil Lyons filed Critical Regenerx Biopharmaceuticals
Publication of WO2008024194A2 publication Critical patent/WO2008024194A2/en
Publication of WO2008024194A3 publication Critical patent/WO2008024194A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients

Abstract

A method of conserving and preparing tissue or cells, other than cardiac tissue or cardiac cells, for transfer, transplant, re-implantation, further study or the like, includes administering to tissue or cells an effective amount of a composition including a polypeptide agent including thymosin beta 4 (TB4), an isoform, analogue or derivative of TB4 having biological activity of TB4, an N-terminal variant of TB4 having biological activity of TB4, a C-terminal variant of TB4 having biological activity of TB4, LKKTET or a conservative variant thereof, LKKTNT or a conservative variant thereof, KLKKTET or a conservative variant thereof, LKKTETQ or a conservative variant thereof, TB4 sulfoxide, TB4ala, TB9, TBIO, TB11, TB12, TB13, TB14, TB15, gelsolin, vitamin D binding protein (DBP), profilin, cofilin, adsevertin, propomyosin, fincilin, depactin, Dnasel, vilin, fragmin, severin, capping protein, ß-actinin or acumentin, or a stimulating agent that stimulates production of the polypeptide agent, or a conservative variant thereof, in the tissue or cells.
PCT/US2007/017482 2006-08-18 2007-08-06 Method of conserving and preparing tissue or cells for transfer, transplant, re-implantation, further study or the like WO2008024194A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83838406P 2006-08-18 2006-08-18
US60/838,384 2006-08-18

Publications (2)

Publication Number Publication Date
WO2008024194A2 WO2008024194A2 (en) 2008-02-28
WO2008024194A3 true WO2008024194A3 (en) 2008-10-16

Family

ID=39107279

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/017482 WO2008024194A2 (en) 2006-08-18 2007-08-06 Method of conserving and preparing tissue or cells for transfer, transplant, re-implantation, further study or the like

Country Status (1)

Country Link
WO (1) WO2008024194A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2476789A (en) * 2009-11-10 2011-07-13 Gl Holdings Inc Bv Use of thymosin for treatment of type 2 diabetes
FR3035407B1 (en) 2015-04-23 2022-06-17 Francais Du Sang Ets METHOD FOR PRESERVING CELLS, TISSUES OR ORGANS IN HYPOTHERMIA
US20230031385A1 (en) * 2021-07-20 2023-02-02 National Health Research Institutes Storage media for preservation of corneal tissue

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SOSNE, G. ET AL.: "Thymosin-beta-4 inhibits comeal epithelial cell apoptosis after ethanol exposure in vitro.", IVOS, vol. 45, no. 4, April 2004 (2004-04-01), pages 1095 - 1100, XP002613895 *

Also Published As

Publication number Publication date
WO2008024194A2 (en) 2008-02-28

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