WO2008021127A2 - Implant de cartilage extensible - Google Patents

Implant de cartilage extensible Download PDF

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Publication number
WO2008021127A2
WO2008021127A2 PCT/US2007/017626 US2007017626W WO2008021127A2 WO 2008021127 A2 WO2008021127 A2 WO 2008021127A2 US 2007017626 W US2007017626 W US 2007017626W WO 2008021127 A2 WO2008021127 A2 WO 2008021127A2
Authority
WO
WIPO (PCT)
Prior art keywords
graft
implantation
defect
cartilage
cells
Prior art date
Application number
PCT/US2007/017626
Other languages
English (en)
Other versions
WO2008021127A3 (fr
Inventor
Marc Long
Twana Davisson
Original Assignee
Howmedica Osteonics Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Howmedica Osteonics Corp. filed Critical Howmedica Osteonics Corp.
Publication of WO2008021127A2 publication Critical patent/WO2008021127A2/fr
Publication of WO2008021127A3 publication Critical patent/WO2008021127A3/fr

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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
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    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30579—Special structural features of bone or joint prostheses not otherwise provided for with mechanically expandable devices, e.g. fixation devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30756—Cartilage endoprostheses
    • A61F2002/30759—Mosaicplasty, i.e. using a plurality of individual cartilage plugs for filling a substantial cartilage defect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30756—Cartilage endoprostheses
    • A61F2002/30764—Cartilage harvest sites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30988—Other joints not covered by any of the groups A61F2/32 - A61F2/4425
    • A61F2002/30996—Other joints not covered by any of the groups A61F2/32 - A61F2/4425 for sterno-clavicular joints
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A61F2002/4631—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor the prosthesis being specially adapted for being cemented
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0061—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof swellable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0069—Three-dimensional shapes cylindrical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00359—Bone or bony tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus

Definitions

  • the present invention relates to the field of medical technology and is generally directed to the treatment of cartilage or cartilage and bone defects through the use of grafts .
  • Cartilage is an avascular connective tissue made up of collagen and/or elastin fibers, and chondrocytes, all of which are embedded in a matrix.
  • cartilage There are three main types of cartilage: elastic, fibrocartilage, and hyaline.
  • Elastic cartilage is found in the outer ear and the epiglottis.
  • Fibrocartilage is found between the bones of the spinal column, hips and pelvis.
  • Hyaline cartilage can be found on the ends of bones which form joints, on the ends of the ribs, on the end of the nose, on the stiff rings around the windpipe, and supporting the larynx.
  • Articular cartilage is a specialized type of hyaline cartilage which covers the surface of joints and provides a durable low friction surface that distributes mechanical forces and protects the joint's underlying bone .
  • hyaline cartilage which is found predominantly in articulating joints, is composed mostly of type II collagen with small amounts of types V, VI, IX, X, and XI collagen also present.
  • fibrocartilage which can also be found in joints, is primarily composed of type I collagen.
  • the fibrocartilaginous tissue that sometimes replaces damaged articular cartilage is composed of type I collagen.
  • the present invention includes a graft that can be used to repair cartilage and methods of producing the graft.
  • the invention also includes a method of treating cartilage defects using the graft.
  • the graft comprises a porous material that is also compressible and/or expandable.
  • the graft can be used as both a scaffold for ex vivo cartilage growth or as an implant used to repair cartilage.
  • the material used in the graft can be implanted alone or in combination with cells and / or biological factors at the time of surgery.
  • the graft may be used for chondral, osteochondral, partial or full repair of cartilage defects.
  • Fig. 1 shows the compressive properties of the material of the invention.
  • Fig 2. shows the expansion of the material of the invention in a cartilage defect.
  • Fig. 3. shows DBM graft filled defects (A and B) and autograft-filled defects (C) after 3 months.
  • Fig. 4. shows Safranin-0 staining of cross sections of goat joints at 3 weeks post-implantation with DBM.
  • Fig 5. shows the expansion of the material inside the defect .
  • the present invention is directed to the repair of cartilage and includes a cartilage graft and a method of repairing a cartilage defect using the cartilage graft.
  • grafts for cartilage repair include porous materials, such as PLA, collagen "sponges”, hyaluronic acid, metals (CoCr, Titanium), PVA, autograft, and allograft osteochondral plugs. None of these materials are both porous and expandable or compressible to a significant amount of their original size.
  • Mosaicplasty involves removing small autologous osteochondral plugs from low weight bearing sites in a patient's joint. The osteochondral plugs are then grafted into a mosaic of holes drilled into the patient's articular cartilage defect site. Some patients who have undergone mosaicplasty have reported decreased pain and improved joint function. Marcacci, M. et al., Arthroscopy 21(4): 462-470 (2005).
  • each one of these therapeutic methods suffer from one or more of the following disadvantages: the risk of patient immune response or disease transmission; limited availability of osteochondral autograft sites; lack of implant adhesion to the defect site; implant deterioration; lack of long-term efficacy; donor site morbidity; patient discomfort; and the failure to restore normal joint function.
  • the OsteospongeTM (Bacterin International, Inc.; Belgrade, MT) has been developed for bone defects. It is a porous, compressible and expandable demineralized bone matrix
  • DBM bone graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft graft
  • a graft comprising a material with sponge-like properties similar to OsteospongeTM is used in the repair of cartilage defects (chondral or osteochondral) .
  • the graft allows cartilage growth, resulting in restoration of function.
  • the present invention is directed to a method for cartilage repair comprising implanting a graft into a cartilage defect site in a patient, wherein the graft comprises a porous material which is also expandable and/or compressible.
  • the material is porous, to allow in-growth of cells.
  • the material is also compressible and/or expandable for better press-fit and chondro-integration.
  • the material should be porous enough to allow cell growth. Each pore may be the same size, or the pores may be of varying sizes, so long as some of the pores are large enough to allow cell growth into the material. Additionally, the pores may vary or change in size on compression and/or expansion of the material. In certain embodiments, the material has pores with a diameter of at least about 10 microns, at least about 20 microns, at least about 30 microns, at least about 40 microns or at least about 50 microns. Larger size pores are also within the scope of the invention, for example at least about 75-1000 microns. [0025]
  • the material used in the invention is expandable and/or compressible by a significant amount. By “expandable by a significant amount” it is meant that the materials expand by at least about 5 or 10% of their original size. By “compressible by a significant amount” it is meant that the materials compress by at least about 5 or 10% of their original size.
  • the material may expand by at least about 5 or 10% to at least about 300% of its original size.
  • the material may expand by at least about 5%, 10%, 20%, 25%, 30%, 50%, 75%, 100%, 150%, 200%, 250%, or 300% of its original size.
  • the material by compress by at least about 10% to at least about 99% of its original size.
  • the material may compress by at least about 5%, 10%, 20%, 25%, 30%, 50%, 75%, or 99% of its original size.
  • the graft and/or material may be bioresorbable, or non-resorbable.
  • grafts While non-resorbable grafts may necessitate the need for an additional operative procedure, clinician control over the duration of time the graft remains intact could allow for increased chondral or osteochondral integration.
  • the graft could be constructed to remain implanted for an indefinite period of time without negatively interfering in any biological processes or causing the patient pain.
  • the graft and/or porous material may be composed of synthetic or natural material, or a combination of both.
  • the natural material may be of human, animal, and/or plant origin.
  • One naturally derived material useful in the grafts of the invention is made of demineralized bone matrix (DBM) .
  • DBM demineralized bone matrix
  • the material when the graft is made of DBM, the material may be processed to allow for variations in degree of mineralization throughout the graft . This may affect the compressible/expandable nature of the graft, so that its compressible nature may vary with location in the graft. This may be particularly advantageous in reconstructive procedures where structural rigidity of a graft is imperative.
  • a devitalized cartilage matrix may be produced using a process similar to that used to create OsteospongeTM.
  • the starting material could be either cartilage only or could be an osteochondral core. Any source of cartilage cells could be used. Either could be processed to achieve a material that is expandable and/or compressible and appropriate for cartilage repair.
  • the graft may include other portions, for example, a bone portion.
  • the graft may consist of a cartilage portion extending or not into the bone portion of the defect .
  • the graft may also consist of a bone portion extending into the cartilage portion of the defect.
  • the graft may consist of two separate implants used in the same defect; a cartilage-appropriate portion and a separate bone-appropriate portion. The two portions may be separated by a membrane to prevent fluid migration or may be used as delivery of biological factors.
  • the graft may be seeded with one or more types of cells prior to, at the time of, or after implantation.
  • “Seeding” the graft with cells refers to the process of inserting, or placing, one or more types of cells into, or onto, at least a portion of the graft.
  • the cells can be placed in or on the porous material of the graft .
  • Suitable cells for seeding the graft include any kind of cartilage producing cells, or any kind of cells which may have a therapeutic affect, either in the graft or by migration out of the graft.
  • Suitable cells include, but are not limited to embryonic stem cells, stem cells, bone marrow cells, mesenchymal cells, progenitor cells, synovium cells, synovial fluid cells, chondroblasts, chondrocytes, osteoblasts, or combinations of these cells.
  • Any cells added to the graft can be retrieved from various sources, including the patient to be treated, other patients of the same species, pools of cells from other patients or animals, individual animals and commercially available cell lines. Cells may be unaltered and seeded onto grafts immediately after removal from the source or remain in culture until being added to the graft. The cells may be allogenic, autogenic, or xenogenic to the patient to be treated. Combinations of cells may be used.
  • the graft can be used as an ex vivo matrix for cell growth and/or may be implanted in situ into a cartilage defect as an in vivo matrix for cell growth.
  • the invention also comprises a graft produced by culturing with cells.
  • the graft can be cultured with appropriate cells ex vivo until cartilage forms and then implanted, cultured with appropriate cells ex vivo and implanted before full cartilage formation, or implanted without any culturing step at all.
  • biological agent it is meant any agent that has, or produces, biological, physiological and/or pharmaceutical activity upon administration to a living organism. These biological agents may be added to the graft at any time, for example, before, during or after implantation.
  • the graft can have varying degrees of biological agent content . The presence of biological agents can be controlled such that growth factor content is maximal or negligible. Biological agent content may vary with depth or location.
  • Suitable biological agents include, but are not limited to, growth factors, cytokines, antibiotics, strontium salts, fluoride salts, calcium salts, sodium salts, bone morphogenetic factors, chemotherapeutic agents, angiogenic factors, osteoconductive agents, chondroconductive agents, inductive agents, painkillers, proteins, peptides, or combinations thereof.
  • Growth factors that can be added to the graft include platelet derived growth factor (PDGP) , transforming growth factor beta (TGF/3) , insulin-related growth factor-I (IGF-I), insulin-related growth factor II (IGF-II), beta-2- microglobulin, bone morphogenetic protein (BMP) , fibroblast growth factor (FGF) , interleukin-1 / S (IL-I ⁇ ) , hepatocyte growth factor (HGF) , cartilage derived morphogenetic protein (CD-MP) , growth differentiation factors (GDFs) , platelet-rich- plasma (PRP), or combinations of growth factors.
  • Chondroinductive agents include prostaglandin E2 , thyroid hormone, dihydroxy vitamin D, ascorbic acid, dexamethasone , staurosporine, dibutyrl cAMP, concavalin A, vanadate, FK506, or combinations of different chondroinductive agents.
  • Antibiotics include tetracycline hydrochloride, vancomycin, cephalosporins, and aminoglycocides such as tobramycin, gentamicin, and combinations thereof. Pain killers include lidocaine hydrochloride, bipivacaine hydrochloride, ketorolac tromethamine and other non-steroidal anti-inflammatory drugs.
  • the biological agent added to the graft can also be a protein or combinations of proteins.
  • proteins of demineralized bone, bone protein (BP) , bone morphogenetic protein (BMP) , BMP5, osteonectin, osteocalcin, osteogenin, or combinations of these proteins can be added to the graft.
  • Suitable biological agents include cis- platinum, ifosfamide, methotrexate, doxorubicin hydrochloride, or combinations thereof.
  • the graft can be implanted dry or hydrated with liquids before, during or after implantation.
  • liquids include, but are not limited to water, saline, and bodily fluids (blood) . All or only part of the graft (for example, the porous material or part thereof) may be hydrated. The hydration by done by any method, including dipping, sprinkling, full or partial submersion, or running under a faucet .
  • the graft may be exposed to the liquid for an instant up to several hours or several weeks, and can be stored in a liquid indefinitely until implantation.
  • the method of the invention can be used to treat any cartilage defect, whether it is in elastic cartilage, fibrocartilage, or hyaline cartilage.
  • the method could be used for cartilage repair in joints, such as a knee, ankle, hip, shoulder, elbow, temporomandibular, sternoclavicular, zygapophyseal, and wrist; or any other place where cartilage is found, such as the ear, nose, ribs, spinal column, pelvis, epiglottis, larynx, and windpipe.
  • the graft may also be used in rhinoplasty procedures, including but not limited to reconstruction via a dorsal septal graft.
  • the graft may be used to repair cartilage during a microtia- atresia surgical correction or in other types of auricular reconstructive procedures, such as those secondary to trauma or cancer.
  • the graft of the invention can be used to repair cartilage in any patient in need thereof.
  • patient is meant any organism which has cartilage, including, but not limited to humans, monkeys, horses, goats, dogs, cats, and rodents .
  • One graft may be used alone to fill the defect, or multiple grafts may be combined to fill one defect (similar to the mosaicplasty technique) .
  • the graft may be used to compliment other cartilage repair procedures, including autograft, allograft, or mosaicplasty procedures.
  • the graft of the invention may be implanted at the same time, before, or after other cartilage repair procedures.
  • the expandable/compressible material may be used to fill small gaps left during the other procedures.
  • the graft can be used to fill either the donor or the recipient sites in mosaicplasty-like procedures, and can be used either alone or in combination with other materials, including allografts, autografts, other biomaterials or other grafts.
  • the graft can be produced in various shapes and sizes.
  • the graft may be produced in a geometric shape, such as a flat sheet, square, rectangle, cylinder, pentagon, hexagon, T- shape, cone, or circle.
  • the graft may also be produced to match the shape of all or part of an anatomical feature, such as an ear, nose, joint, knee, ankle, hip, shoulder, elbow, temporomandibular, sternoclavicular, zygapophyseal , wrist, rib, spinal column, pelvis, epiglottis, larynx, or windpipe.
  • a surgeon may alter the size of the graft material prior to implantation by means of scissors or some other instrument or device used for cutting. This gives the clinician the operative flexibility to customize the fit of the invention without detriment to the patient or the graft itself.
  • the graft Prior to, after, or in the absence of compression, the graft can be shaped by the clinician to match any anatomical intricacies of the surgical implantation site. The graft can then be implanted, either dry or hydrated, via a procedure such as "press fit.” The graft can be compressed prior to implantation, or can be implanted without compression. The graft material may expand to substantially fill the defect after implantation.
  • An undersized void can be created in the cartilage and possibly the adjacent bone where a defect is identified.
  • the surgeon creates a defined defect in the articulating joint where fibrillation or a cartilage defect was identified.
  • the defect may be chondral or osteochondral .
  • the graft which can be oversized compared to the defect, may be compressed and implanted into the defect, either dry or hydrated.
  • the graft may be compressed by any method, including by hand, by squeezing though a conical tube of a desired size, or via surgical instrument.
  • the graft may fill any void space by expanding to substantially fill the total volume of the defect.
  • the constraint created by the undersized defect creates an increased press-fit with the surrounding tissue, enhanced integration and the elimination of micromotion.
  • the graft may also be implanted without a press-fit or interference fit but will expand after implantation due to hydration with body fluids .
  • the graft may be merely press fit into the defect area or an anchor can be used to affix the graft to the defect.
  • Anchors include plates, nails, screws, pins, adhesives, organic glues (such as fibrin glue) , clotting materials or any other material known to be suitable for affixing cartilage or bone grafts. More than one type of anchor may be used to affix the graft to the cartilage defect site.
  • the graft can be compressible in all dimensions, it can be compressed to fit into small articulating joints, such as the hip. Thus, the ability to be compressed in three dimensions allows a graft to be used in the repair of cartilage defects of the hip or other articulating joints or during arthroscopic surgeries.
  • Another embodiment of the invention is a variation of the press-fit technique.
  • One challenge of certain procedures, particularly in the area of oral surgery is primary closure of the wound site post-osseous graft. This occurs when an osseous defect receives a graft intended to serve as a matrix for osseous regeneration. The surgeon faces the challenge of suturing the epithelial layer over the graft.
  • the graft can be compressed and encapsulated in a bioresorbable or non-resorbable capsule.
  • the capsule can be made in a varying array of shapes and sizes.
  • the capsule can be slightly smaller than the defect being grafted, or can be compressed to a size slightly smaller than the defect to be grafted.
  • the capsule can be implanted into the defect and the surgeon sutures the epithelial tissue over the capsule inside of the defect creating a snug fit.
  • the fit of the capsule should be tight enough to remain in place for suturing, but not occupy so much space as to make primary closure a challenge .
  • the blood and fluids in the grafted defect can initiate bioresorbtion of the capsule allowing the material to expand to its full size within the defect. The fit of the material becomes tight with the borders of the defect , minimizing any micromotion within the defect .
  • the surgeon selects the size of the capsule and hydrated material based on the anatomical defect. Multiple capsules could be used if necessitated by the anatomical defect.
  • Instrumentation or imaging techniques to measure and match the cartilage defect and/or surgical instruments used in conjunction with graft implantation may be packaged with the graft as a kit .
  • OsteospongeTM (Bacterin) was used as the graft material in all examples.
  • DBM demineralized bone matrix
  • the chondrocytes were seeded onto the sponges in 1 mL of cell culture medium (DMEM with 25 ug/mL gentamycin and 10% fetal bovine serum) , at 37C° in 24- well plates .
  • the sponges were placed into the plates and the cell solution was placed on top of the sponges at a cell density of 30 million cells/cm 3 .
  • the plates were shaken at 200 rpm for 18 hours.
  • Sponges were analyzed at 3 weeks and 6 weeks for biochemical content, matrix uniformity and biomechanical properties .
  • GAG glyco ⁇ aminoglycan
  • the grafts were successfully implanted into defects created in the lateral and femoral condyle and trochlear grooves of goats.
  • the femoral condyle was chosen because of its heavy weight bearing characteristics while the lateral groove was chosen because it is a lesser weight bearing site.
  • Tubular chisels were used to create and remove chondral and osteochondral cores measuring 4.5 mm in diameter. The remaining defects served as the implantation sites for grafts.
  • One graft consisting of DBM was hydrated with saline and implanted into each defect .
  • Some grafts were combined with approximately 100-300 ul of fibrin glue according to manufacturer's instructions. Success was determined based on the ease of implantation, and whether the implanted grafts remained in the defect for the duration of the study.
  • a second in vivo study examined the fixation of the grafts within an osteochondral defect after implantation.
  • the graft was initially hydrated with PBS.
  • the graft was then compressed from a hydrated diameter of -6mm in diameter into focal osteochondral defects of ⁇ 4.5mm.
  • the grafts and defects were both ⁇ 8mm in depth.
  • the grafts were implanted into the lateral trochlear grooves and the medial femoral condyles of goats.
  • a third in vivo study examined the repair of focal osteochondral defects post-implantation. Results were examined after three months of implantation.
  • the defect was created using a tubular chisel, #15 scalpel blade and a currette.
  • An awl was to create small holes in the subchondral bone, simulating microfracture in the goat. Perforations were made uniformly within the defect sites at an approximate depth of 3 mm.
  • the grafts having initial hydrated diameters of ⁇ 6.5mm and widths of ⁇ 8.5mm, were compressed and implanted into the focal osteochondral defects employing the press-fit technique .

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  • Heart & Thoracic Surgery (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La présente invention concerne une méthode pour réparer des défauts de cartilage chez un patient. Selon la présente invention, un matériel poreux ayant au moins des propriétés extensibles ou compressibles est implanté dans un défaut de cartilage.
PCT/US2007/017626 2006-08-08 2007-08-08 Implant de cartilage extensible WO2008021127A2 (fr)

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US83625306P 2006-08-08 2006-08-08
US60/836,253 2006-08-08
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Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009111069A1 (fr) * 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Produits de recombinaison spongieux, particules de cartilage et associations de produits de recombinaison spongieux et de particules de cartilage
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
USRE42208E1 (en) 2003-04-29 2011-03-08 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
US8480757B2 (en) 2005-08-26 2013-07-09 Zimmer, Inc. Implants and methods for repair, replacement and treatment of disease
US8497121B2 (en) 2006-12-20 2013-07-30 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
US8518433B2 (en) 2003-12-11 2013-08-27 Zimmer, Inc. Method of treating an osteochondral defect
US9138318B2 (en) 2007-04-12 2015-09-22 Zimmer, Inc. Apparatus for forming an implant
US9701940B2 (en) 2005-09-19 2017-07-11 Histogenics Corporation Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
US10167447B2 (en) 2012-12-21 2019-01-01 Zimmer, Inc. Supports and methods for promoting integration of cartilage tissue explants

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050222687A1 (en) * 2004-04-02 2005-10-06 Gordana Vunjak-Novakovic Cartilage implant assembly and method for implantation
US20050064042A1 (en) * 2003-04-29 2005-03-24 Musculoskeletal Transplant Foundation Cartilage implant plug with fibrin glue and method for implantation
US20090291112A1 (en) * 2003-05-16 2009-11-26 Truncale Katherine G Allograft osteochondral plug combined with cartilage particle mixture
US8512730B2 (en) 2004-07-12 2013-08-20 Isto Technologies, Inc. Methods of tissue repair and compositions therefor
US20090149893A1 (en) * 2007-12-05 2009-06-11 Semler Eric J Cancellous Bone Implant for Cartilage Repair
US20080220044A1 (en) * 2007-03-06 2008-09-11 Semler Eric J Cancellous construct with support ring for repair of osteochondral defects
US9072816B2 (en) * 2006-01-18 2015-07-07 Cormatrix Cardiovascular, Inc. Composition for modulating inflammation of cardiovascular tissue
US20130122108A1 (en) * 2006-06-06 2013-05-16 Robert G Matheny Compositions for Regenerating Defective or Absent Myocardium
US20100168869A1 (en) * 2008-12-31 2010-07-01 Howmedica Osteonics Corp. Tissue integration implant
US20100168856A1 (en) * 2008-12-31 2010-07-01 Howmedica Osteonics Corp. Multiple piece tissue void filler
WO2010099463A2 (fr) * 2009-02-27 2010-09-02 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Supports biologiques d'articulations
IN2014MN02576A (fr) * 2012-05-30 2015-07-24 Univ New York
US10245306B2 (en) 2012-11-16 2019-04-02 Isto Technologies Ii, Llc Flexible tissue matrix and methods for joint repair
US10179191B2 (en) 2014-10-09 2019-01-15 Isto Technologies Ii, Llc Flexible tissue matrix and methods for joint repair
US10524774B2 (en) 2015-04-02 2020-01-07 Arthrex, Inc. Method of repairing cartilage defects
WO2016175891A1 (fr) * 2015-04-27 2016-11-03 Corenman Donald Steven Greffe de disque biologique et procédé permettant de soulager douleur lombaire et douleur articulaire
US10524775B2 (en) * 2015-07-02 2020-01-07 Arthrex, Inc. Methods of repairing cartilage defects
US10485665B2 (en) 2015-12-09 2019-11-26 Reconstrata, Llc Apparatus and method for constructing implantable cartilage structures
US9943414B2 (en) 2015-12-30 2018-04-17 Wasas, Llc. System and method for non-binding allograft subtalar joint implant
WO2019142077A1 (fr) * 2018-01-16 2019-07-25 Gyrus Acmi, Inc. Stent urologique

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000009043A1 (fr) * 1998-08-14 2000-02-24 Cambridge Scientific, Inc. Osteo-induction d'allogreffes de corticale par revetement a l'aide de biopolymeres ensemences de cellules osseuses periostales du receveur
US6121042A (en) * 1995-04-27 2000-09-19 Advanced Tissue Sciences, Inc. Apparatus and method for simulating in vivo conditions while seeding and culturing three-dimensional tissue constructs
WO2000064377A1 (fr) * 1999-04-27 2000-11-02 Sulzer Biologics, Inc. Greffe prothetique
WO2001085226A1 (fr) * 2000-05-11 2001-11-15 Smith & Nephew, Inc. Re-implantation tissulaire
WO2003094703A2 (fr) * 2002-05-13 2003-11-20 Articular Engineering, Llc Implant osteochondral issu du genie tissulaire
US20040010312A1 (en) * 2002-07-09 2004-01-15 Albert Enayati Intervertebral prosthesis
WO2005086849A2 (fr) * 2004-03-09 2005-09-22 Osteobiologics, Inc. Support d'implant combine a des tissus autologues ou allogenes

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4627853A (en) * 1985-05-29 1986-12-09 American Hospital Supply Corporation Method of producing prostheses for replacement of articular cartilage and prostheses so produced
US4681763A (en) * 1985-06-11 1987-07-21 University Of Medicine And Dentistry Of New Jersey Composition for stimulating bone growth
US5329846A (en) * 1991-08-12 1994-07-19 Bonutti Peter M Tissue press and system
US20020032488A1 (en) * 1994-05-13 2002-03-14 Brekke John H. Device for regeneration of articular cartilage and other tissue
US20030045943A1 (en) * 1994-05-13 2003-03-06 Brekke John H. Device for regeneration of articular cartilage and other tissue
US5925736A (en) * 1995-01-10 1999-07-20 Fibrogen, Inc. Collagen-based methods and formulations for the treatment of arthritis
US5904716A (en) * 1995-04-26 1999-05-18 Gendler; El Method for reconstituting cartilage tissue using demineralized bone and product thereof
WO1996041818A1 (fr) * 1995-06-09 1996-12-27 Drohan William N Hydrogels de chitine, leurs procedes de fabrication et leur utilisation
US5803891A (en) * 1996-02-01 1998-09-08 Moore Business Forms, Inc. Apparatus of accumulating sheets for a booklet
DE19803673A1 (de) * 1998-01-30 1999-08-05 Norbert M Dr Meenen Biohybrider Gelenkflächenersatz
US5882929A (en) * 1998-04-07 1999-03-16 Tissue Engineering, Inc. Methods and apparatus for the conditioning of cartilage replacement tissue
US6171610B1 (en) * 1998-04-24 2001-01-09 University Of Massachusetts Guided development and support of hydrogel-cell compositions
US6224630B1 (en) * 1998-05-29 2001-05-01 Advanced Bio Surfaces, Inc. Implantable tissue repair device
US20080077251A1 (en) * 1999-06-07 2008-03-27 Chen Silvia S Cleaning and devitalization of cartilage
US6306424B1 (en) * 1999-06-30 2001-10-23 Ethicon, Inc. Foam composite for the repair or regeneration of tissue
US9387094B2 (en) * 2000-07-19 2016-07-12 Warsaw Orthopedic, Inc. Osteoimplant and method of making same
CA2365376C (fr) * 2000-12-21 2006-03-28 Ethicon, Inc. Utilisation d'implants en mousse renforces ayant une meilleure integrite pour la reparation et la regeneration de tissus mous
US6776800B2 (en) * 2001-02-28 2004-08-17 Synthes (U.S.A.) Implants formed with demineralized bone
FI20010540A0 (fi) * 2001-03-16 2001-03-16 Yli Urpo Antti Komposiitti pehmyt- ja kovakudosvammojen korjaamiseksi ja mainitun komposiitin käyttö
JP3646162B2 (ja) * 2001-07-04 2005-05-11 独立行政法人産業技術総合研究所 軟骨組織の再生用移植体
US7166133B2 (en) * 2002-06-13 2007-01-23 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being
US20040166169A1 (en) * 2002-07-15 2004-08-26 Prasanna Malaviya Porous extracellular matrix scaffold and method
US20040062753A1 (en) * 2002-09-27 2004-04-01 Alireza Rezania Composite scaffolds seeded with mammalian cells
US20040078090A1 (en) * 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffolds with tissue fragments
US20040197375A1 (en) * 2003-04-02 2004-10-07 Alireza Rezania Composite scaffolds seeded with mammalian cells
US7901457B2 (en) * 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US20050090899A1 (en) * 2003-10-24 2005-04-28 Dipoto Gene Methods and apparatuses for treating the spine through an access device
US7056337B2 (en) * 2003-10-21 2006-06-06 Cook Incorporated Natural tissue stent
US8133500B2 (en) * 2003-12-04 2012-03-13 Kensey Nash Bvf Technology, Llc Compressed high density fibrous polymers suitable for implant
US8298290B2 (en) * 2004-09-20 2012-10-30 Davol, Inc. Implantable prosthesis for soft tissue repair
US20060085075A1 (en) * 2004-10-04 2006-04-20 Archus Orthopedics, Inc. Polymeric joint complex and methods of use
US8574825B2 (en) * 2007-06-01 2013-11-05 Bacterin International, Inc. Process for demineralization of bone matrix with preservation of natural growth factors
US9125743B2 (en) * 2007-07-16 2015-09-08 Lifenet Health Devitalization and recellularization of cartilage

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6121042A (en) * 1995-04-27 2000-09-19 Advanced Tissue Sciences, Inc. Apparatus and method for simulating in vivo conditions while seeding and culturing three-dimensional tissue constructs
WO2000009043A1 (fr) * 1998-08-14 2000-02-24 Cambridge Scientific, Inc. Osteo-induction d'allogreffes de corticale par revetement a l'aide de biopolymeres ensemences de cellules osseuses periostales du receveur
WO2000064377A1 (fr) * 1999-04-27 2000-11-02 Sulzer Biologics, Inc. Greffe prothetique
WO2001085226A1 (fr) * 2000-05-11 2001-11-15 Smith & Nephew, Inc. Re-implantation tissulaire
WO2003094703A2 (fr) * 2002-05-13 2003-11-20 Articular Engineering, Llc Implant osteochondral issu du genie tissulaire
US20040010312A1 (en) * 2002-07-09 2004-01-15 Albert Enayati Intervertebral prosthesis
WO2005086849A2 (fr) * 2004-03-09 2005-09-22 Osteobiologics, Inc. Support d'implant combine a des tissus autologues ou allogenes

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE43258E1 (en) 2003-04-29 2012-03-20 Musculoskeletal Transplant Foundation Glue for cartilage repair
USRE42208E1 (en) 2003-04-29 2011-03-08 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US8221500B2 (en) 2003-05-16 2012-07-17 Musculoskeletal Transplant Foundation Cartilage allograft plug
US8784863B2 (en) 2003-12-11 2014-07-22 Zimmer, Inc. Particulate cadaveric allogenic cartilage system
US8524268B2 (en) 2003-12-11 2013-09-03 Zimmer, Inc. Cadaveric allogenic human juvenile cartilage implant
US8834914B2 (en) 2003-12-11 2014-09-16 Zimmer, Inc. Treatment methods using a particulate cadaveric allogenic juvenile cartilage particles
US8765165B2 (en) 2003-12-11 2014-07-01 Zimmer, Inc. Particulate cartilage system
US8652507B2 (en) 2003-12-11 2014-02-18 Zimmer, Inc. Juvenile cartilage composition
US8518433B2 (en) 2003-12-11 2013-08-27 Zimmer, Inc. Method of treating an osteochondral defect
US8292968B2 (en) 2004-10-12 2012-10-23 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
US8480757B2 (en) 2005-08-26 2013-07-09 Zimmer, Inc. Implants and methods for repair, replacement and treatment of disease
US9701940B2 (en) 2005-09-19 2017-07-11 Histogenics Corporation Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
US8497121B2 (en) 2006-12-20 2013-07-30 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US8906110B2 (en) 2007-01-24 2014-12-09 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
US9138318B2 (en) 2007-04-12 2015-09-22 Zimmer, Inc. Apparatus for forming an implant
WO2009111069A1 (fr) * 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Produits de recombinaison spongieux, particules de cartilage et associations de produits de recombinaison spongieux et de particules de cartilage
US10167447B2 (en) 2012-12-21 2019-01-01 Zimmer, Inc. Supports and methods for promoting integration of cartilage tissue explants
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
US11555172B2 (en) 2014-12-02 2023-01-17 Ocugen, Inc. Cell and tissue culture container

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