WO2008017925A3 - Pharmacodynamic hybrids endowed of hypoglycemic and no-donor activities obtained combining hydroxylated derivatives of glibenclamide and nitrooxy-substituted carboxylic acids - Google Patents

Pharmacodynamic hybrids endowed of hypoglycemic and no-donor activities obtained combining hydroxylated derivatives of glibenclamide and nitrooxy-substituted carboxylic acids Download PDF

Info

Publication number
WO2008017925A3
WO2008017925A3 PCT/IB2007/002259 IB2007002259W WO2008017925A3 WO 2008017925 A3 WO2008017925 A3 WO 2008017925A3 IB 2007002259 W IB2007002259 W IB 2007002259W WO 2008017925 A3 WO2008017925 A3 WO 2008017925A3
Authority
WO
WIPO (PCT)
Prior art keywords
hypoglycemic
nitrooxy
glibenclamide
pharmacodynamic
endowed
Prior art date
Application number
PCT/IB2007/002259
Other languages
French (fr)
Other versions
WO2008017925A2 (en
Inventor
Aldo Balsamo
Vincenzo Calderone
Simona Rapposelli
Piero Marchetti
Scilla Torri
Original Assignee
Univ Pisa
Aldo Balsamo
Vincenzo Calderone
Simona Rapposelli
Piero Marchetti
Scilla Torri
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pisa, Aldo Balsamo, Vincenzo Calderone, Simona Rapposelli, Piero Marchetti, Scilla Torri filed Critical Univ Pisa
Priority to EP07804717A priority Critical patent/EP2054381A2/en
Publication of WO2008017925A2 publication Critical patent/WO2008017925A2/en
Publication of WO2008017925A3 publication Critical patent/WO2008017925A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
    • C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/59—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to carbon atoms of rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

Compound featuring a hypoglycemic action and in the meantime a release of nitric oxide (NO), said compound having the following general formula (I) : where at least one among R, R1, and R2 is a substitute comprising an nitroxy-ester group bound to a acyl aliphatic, aromatic or aliphatic-aromatic group. The compound can be in particular, used to treat patients affected by NO endogenous deficit responsive to diabetes mellitus of type 2.
PCT/IB2007/002259 2006-08-07 2007-08-06 Pharmacodynamic hybrids endowed of hypoglycemic and no-donor activities obtained combining hydroxylated derivatives of glibenclamide and nitrooxy-substituted carboxylic acids WO2008017925A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07804717A EP2054381A2 (en) 2006-08-07 2007-08-06 Pharmacodynamic hybrids endowed of hypoglycemic and no-donor activities obtained combining hydroxylated derivatives of glibenclamide and nitrooxy-substituted carboxylic acids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000103A ITPI20060103A1 (en) 2006-08-07 2006-08-07 PHARMACODYNAMIC HYBRIDS WITH HYPOGLYCEMIZING ACTIVITY AND NO-DONOR OBTAINED FROM THE CONJUGATION OF HYDROXYLATED GLIBENCLAMIDE DERIVATIVES WITH NITROOSSI-SUBSTITUTED CARBOXYLIC ACIDS.
ITPI2006A000103 2006-08-07

Publications (2)

Publication Number Publication Date
WO2008017925A2 WO2008017925A2 (en) 2008-02-14
WO2008017925A3 true WO2008017925A3 (en) 2008-11-06

Family

ID=38896936

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/002259 WO2008017925A2 (en) 2006-08-07 2007-08-06 Pharmacodynamic hybrids endowed of hypoglycemic and no-donor activities obtained combining hydroxylated derivatives of glibenclamide and nitrooxy-substituted carboxylic acids

Country Status (3)

Country Link
EP (1) EP2054381A2 (en)
IT (1) ITPI20060103A1 (en)
WO (1) WO2008017925A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105237445A (en) * 2015-10-20 2016-01-13 大连九信生物化工科技有限公司 Synthetic process of 4-[2-(5-chloro-2-methoxy benzamide)ethyl]benzsulfamide
JP2023534674A (en) * 2020-07-17 2023-08-10 上海森輝医薬有限公司 Sulfonylurea derivatives and their medicinal use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002005795A2 (en) * 2000-07-14 2002-01-24 Kéri Pharma Kft. Pharmaceutical combinations for treatment and prevention of diabetes mellitus
WO2002030867A2 (en) * 2000-10-12 2002-04-18 Nicox S.A. Drugs for diabetes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002005795A2 (en) * 2000-07-14 2002-01-24 Kéri Pharma Kft. Pharmaceutical combinations for treatment and prevention of diabetes mellitus
WO2002030867A2 (en) * 2000-10-12 2002-04-18 Nicox S.A. Drugs for diabetes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
M.C. BRESCHI, ET AL.: "New NO-releasing pharmacodynamic hydbrids of losartin and its active metabolite: design, synthesis and biopharmacological properties", JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, no. 8, 22 March 2006 (2006-03-22), AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, pages 2628 - 2639, XP002490853 *

Also Published As

Publication number Publication date
EP2054381A2 (en) 2009-05-06
WO2008017925A2 (en) 2008-02-14
ITPI20060103A1 (en) 2008-02-08

Similar Documents

Publication Publication Date Title
WO2008131860A3 (en) Pyridonecarboxamides crop protection agents containing the same method for production and use thereof
WO2009011889A4 (en) Compounds and methods for treatment of sickle cell disease or complications associated therewith
CA2474578A1 (en) Novel pyridin- and pyrimidin-derivatives
WO2006058628A3 (en) Substituted benzoquinolizines as dpp-iv inhibitors for the treatment of diabetes
WO2003033524A3 (en) Peptidyl ketones as inhibitors of dpiv
DK1613740T3 (en) Compositions comprising strains of Lactobacillus plantarum in combination with tannic acid as well as new strains of Lactobacillus plantarum
WO2008005651A3 (en) Cyclic carboxylic acid rhodanine derivatives for the treatment and prevention of tuberculosis
SI2076501T1 (en) Crystalline forms of 3-(5-(2-fhjorophenyl)-(1,2,4)oxadiazol-3-yl)-benzoic acid
WO2010049434A3 (en) Process for relaxing or straightening hair, using weak mono - di - or tricarboxylic acids with heat
WO2009117150A3 (en) Method of treating lupus with ceramide derivatives
MY148483A (en) 4,5-diphenyl-pyrimidinyl-oxy or-mercapto substituted carboxylic acids, method for the production and use thereof as medicaments
WO2007066238A3 (en) Game piece and method of playing game using same
BRPI0414994A (en) polyurethane (pud) dispersion with improved isopropanol strength, flexibility and softness
WO2007099548A3 (en) Novel 11 beta - hydroxyandrosta-4-ene-3-ones
WO2007060448A3 (en) Chemical process for the preparation of an amido-phenoxybenzoic acid compound
WO2007095502A3 (en) Resource sensitive game system & method
WO2008017925A3 (en) Pharmacodynamic hybrids endowed of hypoglycemic and no-donor activities obtained combining hydroxylated derivatives of glibenclamide and nitrooxy-substituted carboxylic acids
WO2007142548A3 (en) Vesicular formulations containing organic acid prodrugs, process for their preparation
YU40202A (en) Novel thiazolidinedione derivatives as antidiabetic agents
WO2008100651A3 (en) Preparation of darifenacin and its salts
WO2007131957A3 (en) Disazo acid dyes
WO2007110173A3 (en) Fungicidal active substance combinations
WO2003070280A3 (en) Absorption enhancing agent
WO2008042497A3 (en) Benzoxazole and benzothiazole compounds useful as authentication compounds in polymer articles
EP1564590A3 (en) Photosensitive composition

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07804717

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2007804717

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: RU