WO2008016237A1 - Polymer injectable detachable coil - Google Patents

Polymer injectable detachable coil Download PDF

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Publication number
WO2008016237A1
WO2008016237A1 PCT/KR2007/003614 KR2007003614W WO2008016237A1 WO 2008016237 A1 WO2008016237 A1 WO 2008016237A1 KR 2007003614 W KR2007003614 W KR 2007003614W WO 2008016237 A1 WO2008016237 A1 WO 2008016237A1
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WO
WIPO (PCT)
Prior art keywords
coil
polymer
platinum
pusher
cavity
Prior art date
Application number
PCT/KR2007/003614
Other languages
French (fr)
Inventor
Sung-Hyun Kim
Sung-Gwon Kang
Original Assignee
S & G Biotech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by S & G Biotech, Inc. filed Critical S & G Biotech, Inc.
Publication of WO2008016237A1 publication Critical patent/WO2008016237A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • A61B17/12113—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/1214—Coils or wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
    • A61B17/12186—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices liquid materials adapted to be injected
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M29/00—Dilators with or without means for introducing media, e.g. remedies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205—Introduction devices
    • A61B2017/12054—Details concerning the detachment of the occluding device from the introduction device
    • A61B2017/12063—Details concerning the detachment of the occluding device from the introduction device electrolytically detachable

Definitions

  • the present invention relates to a polymer injection type detachable coil for embolization useful for treating cerebral aneurysms.
  • Cerebral aneurysms is a disease wherein cerebral artery is abnormally swollen like a balloon. This has a high risk of rupture compared to a normal vessel wall and may cause significant intracerebral hemorrhage including subarachnoid hemorrhage when the cerebral artery is ruptured.
  • a number of clinical treatments for the cerebral aneurysms are previously known and include, for example, a use of aneurysm clips for craniotomy and techniques widely available for preventing repeated bleeding, which approach an artery through a blood vessel and insert a detachable coil for embolization into the aneurysms to isolate them from a blood flow.
  • a primary target for treatment of the cerebral aneurysms is to prevent the repeated bleeding caused by rupture or repeated rupture of the aneurysms and traditional therapies related thereto usually involve the use of aneurysmal clips for craniotomy.
  • Such therapies prevent the blood flow from going into the aneurysms by gripping necks of the aneurysms with metal clips after opening a skull and finding the blood vessels with the aneurysms.
  • the detachable coils for embolization were developed twenty years ago, it was possible to prevent repeated bleeding caused by repeated rupture of aneurysms by such a clinical treatment in that an end of a catheter is inserted into an aneurysm and the detachable coil for embolization is sufficiently put in the aneurysm through the catheter to completely fill up the aneurysm and inhibit the blood flow from going into the aneurysm.
  • the detachable coil has an advantage in that aneurysms can be embolized depending on forms of the aneurysms without blood circulation disorder of parent artery by optionally repeating the insertion and removal of the coil, since the coil is disassembled from a coil pusher if necessary.
  • the treatment of aneurysms by inserting the coil has a risk of causing the rupture of aneurysms as such, and in theory cannot completely fill up the aneurysms by means of coils made of platinum.
  • a preferable treatment method is to insert as many of the coils as possible into the aneurysms as the initial remedy since a possibility for recurrence of the aneurysms, for example, blood circulation toward the aneurysms is high even after the treatment.
  • this method may increase a potential risk of significant complications such as aneurysmal rupture, parent artery occlusion caused by excessive insertion of coils, etc., thereby making it more difficult to treat or remedy the aneurysms.
  • Such conditions are especially a problem in cases where the aneurysms have wider entry parts and/or smaller dimensions thereof.
  • an object of the present invention is to provide a treatment method of cerebral aneurysms in a simple and stable manner, characterized in that it comprises coating common detachable coils for embolization (hereinafter abbrev. to "coil”) with a desired polymer and injecting a specific liquid polymer in the cavities of the coils so as to completely embolize the cerebral aneurysms even by a few coils, which would be unlikely to be cured using conventional coils.
  • coil common detachable coils for embolization
  • Another object of the present invention is to provide a polymer injection type detachable coil for complete embolization of a cerebral aneurysm with a small number of the coils, characterized in that the coil is connected with a hypo-tube and a liquid polymer is injected into the cavity of the coil through the cavity of the hypo-tube.
  • the other object of the present invention is to provide a polymer injection type detachable coil for efficiently and safely injecting a liquid polymer into a cerebral aneurysm, characterized in that the coil has a coil part coated with a thin polymer film to cause the coil to be flexibly extended depending on amounts of the liquid polymer to be injected and prevent the liquid polymer, which was introduced in the blood circulation of the artery, from flowing into the (distal) artery.
  • the present invention provides a polymer injection type detachable coil for embolization, comprising: (I) a platinum coil part 1 for embolization in which a polymer coating film Ia is formed around an outer circumference of a platinum coil Ib having a cavity; (II) a coil pusher 2 in which an insulation coating film 2b is formed around an outer circumference of a hypo-tube 2a having a cavity; (III) a connection part 3, which includes a channel for injecting a specific polymer, that connects the platinum coil to the coil pusher and disconnects the platinum coil from the coil pusher by electrolysis; and (IV) a power supply device 4 for providing the power and performing electrolytic decomposition of the connection part 3.
  • the detachable coil for embolization consists of: a platinum coil part 1 for embolization in which a polymer coating film Ia is formed around an outer circumference of a platinum coil Ib having a cavity; a coil pusher 2 in which an insulation coating film 2b is formed around an outer circumference of a hypo-tube 2a having a cavity; a connection part 3, which includes a channel for injecting a specific polymer, that connects the platinum coil to the coil pusher and disconnects the platinum coil from the coil pusher by electrolysis; and a power supply device 4 for performing the electrolysis of the connection part 3.
  • the detachable coil of the present invention it is possible to inject the liquid polymer into the cavity of the coil when the coil is inserted into an aneurysm and, as a result, completely embolize the aneurysm by only a small number of coils.
  • Fig. 1 is a cross-sectional view schematically illustrating a detachable coil for embolization according to the present invention in a state before injecting the liquid polymer; and Fig. 2 is a cross-sectional view schematically illustrating the coil of the present invention in a state after injecting the liquid polymer.
  • the platinum coil part 1 has the cavity to be filled with the liquid polymer and the thin polymer coating film Ia formed around the outer circumference of the platinum coil Ib to prevent the liquid polymer Ic, which was introduced into the cavity, from flowing into the (distal) artery during blood circulation.
  • the thin coating film formed around the platinum coil is detached from the platinum coil Ib and swollen depending on varied amounts of the liquid polymer Ic.
  • the platinum coil Ib has microfine holes perforated over an entire portion thereof to uniformly leak the liquid polymer Ic out of the cavity of the platinum coil.
  • the coil pusher 2 has the hypo-tube 2a with a cavity, through which the liquid polymer Ic is introduced into the aneurysm, and the insulation coating film 2b formed around the outer circumference of the hypo-tube 2a.
  • a hub 6 is fixed in order to connect a marker 5 and/ or a syringe to the coil pusher, through which the liquid polymer Ic can be injected.
  • the liquid polymer may preferably comprise tricellulose acetate.
  • the connection part 3 between the coil and the coil pusher consists of an insulating polymer tube to hinder current which was applied to separate the platinum coil, from flowing toward the platinum coil.
  • the connection part also securely connects the platinum coil part 1 with the hypo-tube 2a so that both of them are not disconnected from each other by a pressure applied when injecting the liquid polymer.
  • the connection part 3 is preferably an electrolytic polymer tube.
  • the coil pusher 2 consisting of the hypo-tube 2a as a metallic tube having a cavity is connected to the platinum coil part 1 for embolization coated with the polymer to allow the liquid polymer to be injected, and also disconnected from the coil through electrolysis.
  • the liquid polymer is introduced through the cavity of the hypo-tube 2a to fill up the cavity of the platinum coil.
  • the liquid polymer leaking from loops of the platinum coil flows into a polymer pouch which was previously formed around the outer circumference of the platinum coil to increase a volume of the coil inserted into the aneurysm and completely fill up a spacing between the coil loops, thereby achieving the complete embolization of the aneurysm, even when using only one or two platinum coil(s).
  • the polymer coating formed around the outer circumference of the platinum coil beforehand can restrict behavior of the liquid polymer introduced.
  • the platinum coil inserted into the aneurysm serves as a frame to prevent the liquid polymer from flowing along blood circulation in the artery and into the distal artery.
  • the platinum coil is also preferable to selectively embolize only aneurysms by injecting the liquid polymer along the platinum coil frame.
  • the platinum coil according to the present invention has an advantage in that it can safely embolize any of the aneurysms including, for example, macro- aneurysms which need a lot of platinum coils, small sized aneurysms which have a difficulty in inserting the coils, etc.
  • the present invention can completely embolize cerebral aneurysms using a small number of coils, more specifically, detachable coils for embolization which are used to treat the cerebral aneurysms, by injecting a specific liquid polymer in response to different sizes and forms of the aneurysms into cavities of the coils, thereby considerably reducing complications related to the treatment of the cerebral aneurysms and recurrence thereof.
  • Figure 1 is a cross- sectional view schematically illustrating a detachable coil for embolization according to the present invention in a state before injecting the liquid polymer; and Figure 2 is a cross-sectional view schematically illustrating the coil of the present invention in a state after injecting the liquid polymer.
  • the polymer injection type detachable coil for embolization according to the present invention is useful for treating cerebral aneurysms.

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  • Life Sciences & Earth Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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Abstract

Disclosed is a detachable coil for embolization capable of injecting a liquid polymer and useful for treating cerebral aneurysms, comprising: (I) a platinum coil part 1 for embolization in which a polymer coating film Ia is formed around an outer circumference of a platinum coil Ib having a cavity; (II) a coil pusher 2 in which an insulation coating film 2b is formed around an outer circumference of a hypo-tube 2a having a cavity; (III) a connection part 3, which includes a channel for injecting a specific polymer, that connects the platinum coil to the coil pusher and disconnects the platinum coil from the coil pusher by electrolysis; and (IV) a power supply device 4 for providing the power and performing the electrolysis of the connection part 3.

Description

POLYMER INJECTABLE DETACHABLE COIL
TECHNICAL FIELD
The present invention relates to a polymer injection type detachable coil for embolization useful for treating cerebral aneurysms.
Cerebral aneurysms is a disease wherein cerebral artery is abnormally swollen like a balloon. This has a high risk of rupture compared to a normal vessel wall and may cause significant intracerebral hemorrhage including subarachnoid hemorrhage when the cerebral artery is ruptured. A number of clinical treatments for the cerebral aneurysms are previously known and include, for example, a use of aneurysm clips for craniotomy and techniques widely available for preventing repeated bleeding, which approach an artery through a blood vessel and insert a detachable coil for embolization into the aneurysms to isolate them from a blood flow.
A primary target for treatment of the cerebral aneurysms is to prevent the repeated bleeding caused by rupture or repeated rupture of the aneurysms and traditional therapies related thereto usually involve the use of aneurysmal clips for craniotomy. Such therapies prevent the blood flow from going into the aneurysms by gripping necks of the aneurysms with metal clips after opening a skull and finding the blood vessels with the aneurysms. BACKGROUND ART
Since the detachable coils for embolization were developed twenty years ago, it was possible to prevent repeated bleeding caused by repeated rupture of aneurysms by such a clinical treatment in that an end of a catheter is inserted into an aneurysm and the detachable coil for embolization is sufficiently put in the aneurysm through the catheter to completely fill up the aneurysm and inhibit the blood flow from going into the aneurysm. The detachable coil has an advantage in that aneurysms can be embolized depending on forms of the aneurysms without blood circulation disorder of parent artery by optionally repeating the insertion and removal of the coil, since the coil is disassembled from a coil pusher if necessary. However, the treatment of aneurysms by inserting the coil has a risk of causing the rupture of aneurysms as such, and in theory cannot completely fill up the aneurysms by means of coils made of platinum. Briefly, it is difficult to charge the aneurysms with the coils by 50 to 60% or more, in terms of volume of the aneurysms. For the reasons as described above, a preferable treatment method is to insert as many of the coils as possible into the aneurysms as the initial remedy since a possibility for recurrence of the aneurysms, for example, blood circulation toward the aneurysms is high even after the treatment. But this method may increase a potential risk of significant complications such as aneurysmal rupture, parent artery occlusion caused by excessive insertion of coils, etc., thereby making it more difficult to treat or remedy the aneurysms. Such conditions are especially a problem in cases where the aneurysms have wider entry parts and/or smaller dimensions thereof.
Due to such incompletion or defects of the coil embolization as disclosed above, attempts of late have been made to inject a specific liquid polymer such as tricellulose acetate into a cerebral aneurysm, the liquid polymer being reacted with the blood flow to cause polymerization, and in turn, solidification thereof. However, the liquid polymer passes through the blood circulation of artery with a rapid flow rate, reaches blood vessels at distal sites (usually referred to as "distal branch") and causes severe complications such as occlusion. Consequently, it is still hard to apply the above approach to clinical treatments.
DISCLOSURE OF INVENTION
(TECHNICAL PROBLEM) Accordingly, the present invention is directed to solve the problems of conventional treatments as described above and, an object of the present invention is to provide a treatment method of cerebral aneurysms in a simple and stable manner, characterized in that it comprises coating common detachable coils for embolization (hereinafter abbrev. to "coil") with a desired polymer and injecting a specific liquid polymer in the cavities of the coils so as to completely embolize the cerebral aneurysms even by a few coils, which would be unlikely to be cured using conventional coils.
Another object of the present invention is to provide a polymer injection type detachable coil for complete embolization of a cerebral aneurysm with a small number of the coils, characterized in that the coil is connected with a hypo-tube and a liquid polymer is injected into the cavity of the coil through the cavity of the hypo-tube.
Still the other object of the present invention is to provide a polymer injection type detachable coil for efficiently and safely injecting a liquid polymer into a cerebral aneurysm, characterized in that the coil has a coil part coated with a thin polymer film to cause the coil to be flexibly extended depending on amounts of the liquid polymer to be injected and prevent the liquid polymer, which was introduced in the blood circulation of the artery, from flowing into the (distal) artery.
(TECHNICAL MEANS TO SOLVE THE PROBLEM)
In order to achieve the objects described above, the present invention provides a polymer injection type detachable coil for embolization, comprising: (I) a platinum coil part 1 for embolization in which a polymer coating film Ia is formed around an outer circumference of a platinum coil Ib having a cavity; (II) a coil pusher 2 in which an insulation coating film 2b is formed around an outer circumference of a hypo-tube 2a having a cavity; (III) a connection part 3, which includes a channel for injecting a specific polymer, that connects the platinum coil to the coil pusher and disconnects the platinum coil from the coil pusher by electrolysis; and (IV) a power supply device 4 for providing the power and performing electrolytic decomposition of the connection part 3.
Hereinafter, the present invention will be described in detail, especially, in view of technical construction thereof in conjunction with the accompanying drawings.
At first, as shown in Fig. 1 and Fig. 2, the detachable coil for embolization according to the present invention consists of: a platinum coil part 1 for embolization in which a polymer coating film Ia is formed around an outer circumference of a platinum coil Ib having a cavity; a coil pusher 2 in which an insulation coating film 2b is formed around an outer circumference of a hypo-tube 2a having a cavity; a connection part 3, which includes a channel for injecting a specific polymer, that connects the platinum coil to the coil pusher and disconnects the platinum coil from the coil pusher by electrolysis; and a power supply device 4 for performing the electrolysis of the connection part 3.
Using the detachable coil of the present invention, it is possible to inject the liquid polymer into the cavity of the coil when the coil is inserted into an aneurysm and, as a result, completely embolize the aneurysm by only a small number of coils.
Fig. 1 is a cross-sectional view schematically illustrating a detachable coil for embolization according to the present invention in a state before injecting the liquid polymer; and Fig. 2 is a cross-sectional view schematically illustrating the coil of the present invention in a state after injecting the liquid polymer.
The platinum coil part 1 has the cavity to be filled with the liquid polymer and the thin polymer coating film Ia formed around the outer circumference of the platinum coil Ib to prevent the liquid polymer Ic, which was introduced into the cavity, from flowing into the (distal) artery during blood circulation. When injecting the liquid polymer Ic, the thin coating film formed around the platinum coil is detached from the platinum coil Ib and swollen depending on varied amounts of the liquid polymer Ic. The platinum coil Ib has microfine holes perforated over an entire portion thereof to uniformly leak the liquid polymer Ic out of the cavity of the platinum coil.
Next, the coil pusher 2 has the hypo-tube 2a with a cavity, through which the liquid polymer Ic is introduced into the aneurysm, and the insulation coating film 2b formed around the outer circumference of the hypo-tube 2a. To the end of a proximal part of the coil pusher 2, a hub 6 is fixed in order to connect a marker 5 and/ or a syringe to the coil pusher, through which the liquid polymer Ic can be injected.
The liquid polymer may preferably comprise tricellulose acetate. Moreover, the connection part 3 between the coil and the coil pusher consists of an insulating polymer tube to hinder current which was applied to separate the platinum coil, from flowing toward the platinum coil. The connection part also securely connects the platinum coil part 1 with the hypo-tube 2a so that both of them are not disconnected from each other by a pressure applied when injecting the liquid polymer. The connection part 3 is preferably an electrolytic polymer tube. According to the present invention, the coil pusher 2 consisting of the hypo-tube 2a as a metallic tube having a cavity is connected to the platinum coil part 1 for embolization coated with the polymer to allow the liquid polymer to be injected, and also disconnected from the coil through electrolysis. After inserting the platinum coil part 1 into the aneurysm, the liquid polymer is introduced through the cavity of the hypo-tube 2a to fill up the cavity of the platinum coil. Alternatively, as shown in Fig. 2, the liquid polymer leaking from loops of the platinum coil flows into a polymer pouch which was previously formed around the outer circumference of the platinum coil to increase a volume of the coil inserted into the aneurysm and completely fill up a spacing between the coil loops, thereby achieving the complete embolization of the aneurysm, even when using only one or two platinum coil(s).
The polymer coating formed around the outer circumference of the platinum coil beforehand can restrict behavior of the liquid polymer introduced. In addition, the platinum coil inserted into the aneurysm serves as a frame to prevent the liquid polymer from flowing along blood circulation in the artery and into the distal artery. The platinum coil is also preferable to selectively embolize only aneurysms by injecting the liquid polymer along the platinum coil frame.
Finally, since the complete embolization of cerebral aneurysms can be expected using one or two platinum coil(s), the platinum coil according to the present invention has an advantage in that it can safely embolize any of the aneurysms including, for example, macro- aneurysms which need a lot of platinum coils, small sized aneurysms which have a difficulty in inserting the coils, etc.
(ADVANTAGEOUS EFFECTS)
As described in detail above, the present invention can completely embolize cerebral aneurysms using a small number of coils, more specifically, detachable coils for embolization which are used to treat the cerebral aneurysms, by injecting a specific liquid polymer in response to different sizes and forms of the aneurysms into cavities of the coils, thereby considerably reducing complications related to the treatment of the cerebral aneurysms and recurrence thereof.
The above detailed description and the accompanying drawings are intended to simply illustrate the invention and do not limit the scope of the present invention. It is understood that various other modifications and variations will be apparent to and can be readily made by those skilled in the art without departing from the scope and spirit of the present invention as defined by the appended claims.
BRIEF DESCRIPTION OF THE DRAWINGS The above objects and other aspects of the present invention will be apparent with reference to accompanying drawing in which:
Figure 1 is a cross- sectional view schematically illustrating a detachable coil for embolization according to the present invention in a state before injecting the liquid polymer; and Figure 2 is a cross-sectional view schematically illustrating the coil of the present invention in a state after injecting the liquid polymer. INDUSTRIAL APPLICABILITY
As described above, the polymer injection type detachable coil for embolization according to the present invention is useful for treating cerebral aneurysms.

Claims

WHAT IS CLAIMED IS:
1. A polymer injection type detachable coil for embolization, comprising: (I) a platinum coil part 1 for embolization in which a polymer coating film Ia is formed around an outer circumference of a platinum coil Ib having a cavity; (II) a coil pusher 2 in which an insulation coating film 2b is formed around an outer circumference of a hypo-tube 2a having a cavity; (III) a connection part 3, which includes a channel for injecting a specific polymer, that connects the platinum coil to the coil pusher and disconnects the platinum coil from the coil pusher by electrolysis; and (IV) a power supply device 4 for providing the power and performing the electrolysis of the connection part 3.
2. The coil according to claim 1, further comprising a marker 5 and a hub 6 fixed to a rear end of the coil pusher 2 in order.
3. The coil according to claim 1, wherein the platinum coil Ib has microfine holes perforated over an entire portion thereof.
4. The coil according to claim 1 , wherein the connection part 3 is an insulating polymer tube.
5. The coil according to claim 1, wherein the polymer coating film Ia formed around an outer circumference of the platinum coil Ib is detached from the platinum coil Ib and swollen in a pouch form by a liquid polymer Ic when the liquid polymer Ic is injected into the cavity of the coil.
6. The coil according to claim 1, wherein the connection part 3 is an electrolytic polymer tube.
PCT/KR2007/003614 2006-08-01 2007-07-27 Polymer injectable detachable coil WO2008016237A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2006-0072497 2006-08-01
KR1020060072497A KR100745046B1 (en) 2006-08-01 2006-08-01 Polymer injectable detachable coil

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WO2008016237A1 true WO2008016237A1 (en) 2008-02-07

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6335384B1 (en) * 1996-01-31 2002-01-01 Micro Therapeutics, Inc. Methods for embolizing blood vessels
WO2004024207A1 (en) * 2002-09-13 2004-03-25 Kaneka Corporation Embolization device for vessel cavity in vivo
WO2005032337A2 (en) * 2002-07-23 2005-04-14 Micrus Corporation Vasoocclusive coil with enhanced therapeutic strand structure
US20050158359A1 (en) * 2003-05-06 2005-07-21 Epstein Samuel J. Processes for producing polymer coatings for release of therapeutic agent

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6335384B1 (en) * 1996-01-31 2002-01-01 Micro Therapeutics, Inc. Methods for embolizing blood vessels
WO2005032337A2 (en) * 2002-07-23 2005-04-14 Micrus Corporation Vasoocclusive coil with enhanced therapeutic strand structure
WO2004024207A1 (en) * 2002-09-13 2004-03-25 Kaneka Corporation Embolization device for vessel cavity in vivo
US20050158359A1 (en) * 2003-05-06 2005-07-21 Epstein Samuel J. Processes for producing polymer coatings for release of therapeutic agent

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