WO2008015429A3 - Composés pharmaceutiques - Google Patents

Composés pharmaceutiques Download PDF

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Publication number
WO2008015429A3
WO2008015429A3 PCT/GB2007/002926 GB2007002926W WO2008015429A3 WO 2008015429 A3 WO2008015429 A3 WO 2008015429A3 GB 2007002926 W GB2007002926 W GB 2007002926W WO 2008015429 A3 WO2008015429 A3 WO 2008015429A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical compounds
formula
conh2
tautomer
solvate
Prior art date
Application number
PCT/GB2007/002926
Other languages
English (en)
Other versions
WO2008015429A2 (fr
Inventor
Robert George Boyle
Stuart Travers
Original Assignee
Sentinel Oncology Ltd
Robert George Boyle
Stuart Travers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0615299A external-priority patent/GB0615299D0/en
Application filed by Sentinel Oncology Ltd, Robert George Boyle, Stuart Travers filed Critical Sentinel Oncology Ltd
Publication of WO2008015429A2 publication Critical patent/WO2008015429A2/fr
Publication of WO2008015429A3 publication Critical patent/WO2008015429A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
    • C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
    • C07D241/52—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un composé de formule (I) ou un sel, solvate ou tautomère de celui-ci, présentant une activité inhibitrice de PARP. Dans la formule (I) Q est CN ou CONH2 et est lié soit à la position 'a' ou à la position 'b' sur le même noyau benzène; Y1 est N ou N+-O-; Y2 est N ou CR3; Y3 est N ou N+-O-; à condition que lorsque Y2 est CR3, alors Y3 est N+-O-; m est 0, 1 or 2; et R1 et R2 sont tels que définis dans les revendications.
PCT/GB2007/002926 2006-08-01 2007-08-01 Composés pharmaceutiques WO2008015429A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US82103106P 2006-08-01 2006-08-01
GB0615299.5 2006-08-01
GB0615299A GB0615299D0 (en) 2006-08-01 2006-08-01 Pharmaceutical compounds
US60/821,031 2006-08-01

Publications (2)

Publication Number Publication Date
WO2008015429A2 WO2008015429A2 (fr) 2008-02-07
WO2008015429A3 true WO2008015429A3 (fr) 2008-10-02

Family

ID=38692040

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/002926 WO2008015429A2 (fr) 2006-08-01 2007-08-01 Composés pharmaceutiques

Country Status (1)

Country Link
WO (1) WO2008015429A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108138177B9 (zh) 2015-07-23 2021-08-13 法国居里学院 Dbait分子与PARP抑制剂的组合用于治疗癌症的用途
WO2018162439A1 (fr) 2017-03-08 2018-09-13 Onxeo Nouveau biomarqueur prédictif de la sensibilité à un traitement du cancer avec une molécule dbait
US20200407720A1 (en) 2018-03-13 2020-12-31 Onxeo A dbait molecule against acquired resistance in the treatment of cancer
WO2021148581A1 (fr) 2020-01-22 2021-07-29 Onxeo Nouvelle molécule dbait et son utilisation
WO2023019912A1 (fr) * 2021-08-16 2023-02-23 杭州瑞臻医药有限公司 Dioxyde de benzotriazine et composition pharmaceutique associée

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003007959A1 (fr) * 2001-07-16 2003-01-30 Fujisawa Pharmaceutical Co., Ltd. Derives de quinoxaline ayant une action inhibitrice sur parp
WO2003062234A1 (fr) * 2002-01-23 2003-07-31 Yamanouchi Pharmaceutical Co., Ltd. Composes de quinoxaline
EP1468688A2 (fr) * 2003-03-14 2004-10-20 Auckland Uniservices Limited Composées contenants des derivées du N-monooxyde de benzoazin et du 1,4-dioxyde de benzoazin pour le traitement du cancère

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003007959A1 (fr) * 2001-07-16 2003-01-30 Fujisawa Pharmaceutical Co., Ltd. Derives de quinoxaline ayant une action inhibitrice sur parp
WO2003062234A1 (fr) * 2002-01-23 2003-07-31 Yamanouchi Pharmaceutical Co., Ltd. Composes de quinoxaline
EP1468688A2 (fr) * 2003-03-14 2004-10-20 Auckland Uniservices Limited Composées contenants des derivées du N-monooxyde de benzoazin et du 1,4-dioxyde de benzoazin pour le traitement du cancère

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FUCHS T ET AL: "3-amino-1,2,4-benzotriazine 4-oxide: characterization of a new metabolite arising from bioreductive processing of the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine)", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 66, no. 1, 8 December 2000 (2000-12-08), pages 107 - 114, XP002407530, ISSN: 0022-3263 *
GIBSON K H ET AL: "Epidermal growth factor receptor tyrosine kinase: structure-activity relationships and antitumour activity of novel quinazolines", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 7, no. 21, 4 November 1997 (1997-11-04), pages 2723 - 2728, XP004136520, ISSN: 0960-894X *
HAY M P ET AL: "Structure-activity relationships of 1,2,4-benzotriazine 1,4-dioxides as hypoxia-selective analogues of tirapazamine", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 46, no. 1, 2 December 2002 (2002-12-02), pages 169 - 182, XP002404330, ISSN: 0022-2623 *
HWANG JAE-TAEG ET AL: "Reaction of the hypoxia-selective antitumor agent tirapazamine with a C1'-radical in single-stranded and double-stranded DNA: The drug and its metabolites can serve as surrogates for molecular oxygen in radical-mediated DNA damage reactions", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, vol. 38, no. 43, 26 October 1999 (1999-10-26), pages 14248 - 14255, XP002407531, ISSN: 0006-2960 *

Also Published As

Publication number Publication date
WO2008015429A2 (fr) 2008-02-07

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