WO2008015383A3 - Activité anticancéreuse des protéines bmp-9 et bmp-10 et leur utilisation dans les traitements du cancer - Google Patents
Activité anticancéreuse des protéines bmp-9 et bmp-10 et leur utilisation dans les traitements du cancer Download PDFInfo
- Publication number
- WO2008015383A3 WO2008015383A3 PCT/GB2007/002755 GB2007002755W WO2008015383A3 WO 2008015383 A3 WO2008015383 A3 WO 2008015383A3 GB 2007002755 W GB2007002755 W GB 2007002755W WO 2008015383 A3 WO2008015383 A3 WO 2008015383A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- bmp
- breast
- prostate cancer
- cancer therapies
- therapies
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
L'invention concerne le rôle des protéines BMP-9 et/ou BMP-10 dans le traitement du cancer du sein ou de la prostate.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0615129.4 | 2006-07-29 | ||
GBGB0615129.4A GB0615129D0 (en) | 2006-07-29 | 2006-07-29 | Anti-cancer activity of BMP-9 and BMP-10 and their use in cancer therapies |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2008015383A2 WO2008015383A2 (fr) | 2008-02-07 |
WO2008015383A3 true WO2008015383A3 (fr) | 2008-08-14 |
WO2008015383A8 WO2008015383A8 (fr) | 2009-07-16 |
Family
ID=37006438
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2007/002755 WO2008015383A2 (fr) | 2006-07-29 | 2007-07-20 | Activité anticancéreuse des protéines bmp-9 et bmp-10 et leur utilisation dans les traitements du cancer |
Country Status (2)
Country | Link |
---|---|
GB (1) | GB0615129D0 (fr) |
WO (1) | WO2008015383A2 (fr) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2332977B1 (fr) | 2004-07-23 | 2015-11-25 | Acceleron Pharma Inc. | Polypeptides du récepteur AvtRII |
US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
DK1973559T3 (da) | 2005-11-23 | 2013-03-25 | Acceleron Pharma Inc | Activin-ActRIIa antagonister samt anvendelser til fremme af knoglevækst |
US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
CN103920139B (zh) | 2007-02-01 | 2018-02-02 | 阿塞勒隆制药公司 | 活化素‑actriia拮抗剂及在治疗或预防乳腺癌中的用途 |
TWI782836B (zh) | 2007-02-02 | 2022-11-01 | 美商艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
TWI459963B (zh) | 2007-02-09 | 2014-11-11 | Acceleron Pharma Inc | 包含ActRIIa-Fc融合蛋白的醫藥組合物;ActRIIa-Fc融合蛋白於治療或預防與癌症相關的骨質流失之用途;ActRIIa-Fc融合蛋白於治療或預防多發性骨髓瘤之用途 |
CN107412734A (zh) | 2007-09-18 | 2017-12-01 | 阿塞勒隆制药公司 | 活化素‑actriia拮抗剂和减少或抑制fsh分泌的用途 |
WO2009084739A1 (fr) * | 2007-12-28 | 2009-07-09 | Kyowa Hakko Kirin Co., Ltd. | Procédé et composition pharmaceutique pour le traitement du cancer utilisant la protéine bmp10 |
WO2009084738A1 (fr) * | 2007-12-28 | 2009-07-09 | Kyowa Hakko Kirin Co., Ltd. | Procédé et composition pharmaceutique pour le traitement du cancer utilisant la protéine bmp9 |
US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
TWI626945B (zh) | 2008-08-14 | 2018-06-21 | 艾瑟勒朗法瑪公司 | 使用gdf阱以增加紅血球水平 |
AU2010204985A1 (en) | 2009-01-13 | 2011-08-04 | Acceleron Pharma Inc. | Methods for increasing adiponectin |
EP2440576A4 (fr) | 2009-06-08 | 2013-11-20 | Acceleron Pharma Inc | Procédé visant à augmenter le nombre d'adipocytes thermogènes |
KR20210034684A (ko) | 2009-06-12 | 2021-03-30 | 악셀레론 파마 인코포레이티드 | 절두된 ActRIIB-FC 융합 단백질 |
EP2501400B1 (fr) | 2009-11-17 | 2017-11-01 | Acceleron Pharma, Inc. | Protéines actriib et variants et utilisations de celles-ci se rapportant à l'induction de l'utrophine pour une thérapie de la dystrophie musculaire |
JP2014502260A (ja) | 2010-11-08 | 2014-01-30 | アクセルロン ファーマ, インコーポレイテッド | Actriia結合剤およびその使用 |
US9809636B2 (en) * | 2012-04-06 | 2017-11-07 | Acceleron Pharma Inc. | Methods for increasing red blood cell levels comprising administering BMP9 |
KR102279522B1 (ko) | 2012-11-02 | 2021-07-19 | 셀진 코포레이션 | 골 및 다른 장애를 치료하기 위한 액티빈-actrii 길항제 및 용도 |
EP3154566B1 (fr) | 2014-06-13 | 2022-08-03 | Acceleron Pharma Inc. | Antagoniste actrii pour le traitement et la prevention d'un ulcere cutane chez un sujet ayant l'anemie |
MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
HUE062189T2 (hu) | 2014-12-03 | 2023-09-28 | Celgene Corp | Aktivin-ACTRII-antagonisták és alkalmazások mielodiszpláziás szindróma kezelésére |
US11578110B2 (en) | 2015-08-25 | 2023-02-14 | Histide Ag | Compounds for inducing tissue formation and uses thereof |
EP3998076A1 (fr) * | 2015-09-17 | 2022-05-18 | Histide AG | Association pharmaceutique d'agoniste de recepteur de facteur de croissance et d'inhibiteur de proteine d'adhesion pour convertir une cellule neoplastique en cellule non-neoplastique, et ses utilisations |
SI3349776T1 (sl) * | 2015-09-17 | 2021-04-30 | Histide Ag | Farmacevtska asociacija agonista receptorja rastnega faktorja in zaviralca adhezijskega proteina za pretvorbo neoplastične celice v ne-neoplastično celico in njena uporaba |
WO2023069447A1 (fr) * | 2021-10-18 | 2023-04-27 | The Uab Research Foundation | Bmp9 ou agoniste de celui-ci et ses utilisations en rapport avec la réduction des métastases du cancer |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1435243A2 (fr) * | 1998-11-13 | 2004-07-07 | Curis, Inc. | Procédés servant à soulager les symptomes du cancer |
US20060039949A1 (en) * | 2004-08-20 | 2006-02-23 | Nycz Jeffrey H | Acetabular cup with controlled release of an osteoinductive formulation |
WO2006029406A2 (fr) * | 2004-09-09 | 2006-03-16 | Stryker Corporation | Methodes de traitement de tumeurs osseuses |
-
2006
- 2006-07-29 GB GBGB0615129.4A patent/GB0615129D0/en not_active Ceased
-
2007
- 2007-07-20 WO PCT/GB2007/002755 patent/WO2008015383A2/fr active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1435243A2 (fr) * | 1998-11-13 | 2004-07-07 | Curis, Inc. | Procédés servant à soulager les symptomes du cancer |
US20060039949A1 (en) * | 2004-08-20 | 2006-02-23 | Nycz Jeffrey H | Acetabular cup with controlled release of an osteoinductive formulation |
WO2006029406A2 (fr) * | 2004-09-09 | 2006-03-16 | Stryker Corporation | Methodes de traitement de tumeurs osseuses |
Non-Patent Citations (3)
Title |
---|
DATABASE EMBL [online] 11 March 2004 (2004-03-11), ROSEN C.A. ET AL.: "New albumin fusion proteins useful for preparing a composition for treating diabetes mellitus", XP002474103, retrieved from WWW.EBI.AC.UK accession no. ADH22105 * |
SONG J.J. ET AL.: "Bone morphogentic protein-9 binds to liver cells and stimulates proliferation.", ENDOCRINOLOGY, vol. 136, no. 10, 1995, pages 4293 - 4297, XP002474102 * |
VARADY P. ET AL.: "Morphologic analysis of BMP-9 gene therapy induced osteogenesis.", HUMAN GENE THERAPY, vol. 12, 10 April 2001 (2001-04-10), pages 697 - 710, XP002474101 * |
Also Published As
Publication number | Publication date |
---|---|
WO2008015383A8 (fr) | 2009-07-16 |
WO2008015383A2 (fr) | 2008-02-07 |
GB0615129D0 (en) | 2006-09-06 |
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