WO2008014054A3 - Compositions à base de variantes de bmp-7, procédés et utilisations - Google Patents

Compositions à base de variantes de bmp-7, procédés et utilisations Download PDF

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Publication number
WO2008014054A3
WO2008014054A3 PCT/US2007/070584 US2007070584W WO2008014054A3 WO 2008014054 A3 WO2008014054 A3 WO 2008014054A3 US 2007070584 W US2007070584 W US 2007070584W WO 2008014054 A3 WO2008014054 A3 WO 2008014054A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
bmp
variant compositions
peptide chains
variant
Prior art date
Application number
PCT/US2007/070584
Other languages
English (en)
Other versions
WO2008014054A2 (fr
Inventor
Bernard Amegadzie
Mark R Cunningham
Haimanti Dorai
Jeffrey Luo
Juliane Mills
Bethany Swencki-Underwood
Original Assignee
Centocor Inc
Bernard Amegadzie
Mark R Cunningham
Haimanti Dorai
Jeffrey Luo
Juliane Mills
Bethany Swencki-Underwood
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centocor Inc, Bernard Amegadzie, Mark R Cunningham, Haimanti Dorai, Jeffrey Luo, Juliane Mills, Bethany Swencki-Underwood filed Critical Centocor Inc
Priority to EP07798210A priority Critical patent/EP2056852A4/fr
Priority to JP2009521874A priority patent/JP2009544325A/ja
Publication of WO2008014054A2 publication Critical patent/WO2008014054A2/fr
Publication of WO2008014054A3 publication Critical patent/WO2008014054A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des chaînes de peptides de variantes de hBMP-7 (Human Bone Morphogenic Protein), des acides nucléiques codant ces chaînes de peptides, ainsi que des procédés de fabrication et d'utilisation de ces chaînes de peptides.
PCT/US2007/070584 2006-07-27 2007-06-07 Compositions à base de variantes de bmp-7, procédés et utilisations WO2008014054A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP07798210A EP2056852A4 (fr) 2006-07-27 2007-06-07 Compositions à base de variantes de bmp-7, procédés et utilisations
JP2009521874A JP2009544325A (ja) 2006-07-27 2007-06-07 Ｂｍｐ−７変異体組成物、方法および使用

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82053806P 2006-07-27 2006-07-27
US60/820,538 2006-07-27

Publications (2)

Publication Number Publication Date
WO2008014054A2 WO2008014054A2 (fr) 2008-01-31
WO2008014054A3 true WO2008014054A3 (fr) 2009-04-09

Family

ID=38982164

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/070584 WO2008014054A2 (fr) 2006-07-27 2007-06-07 Compositions à base de variantes de bmp-7, procédés et utilisations

Country Status (3)

Country Link
EP (1) EP2056852A4 (fr)
JP (1) JP2009544325A (fr)
WO (1) WO2008014054A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101274930B1 (ko) * 2011-06-03 2013-06-17 전남대학교산학협력단 골 형성 또는 혈관신생 촉진용 펩타이드 ｂｆｐ 4 및 이의 용도
KR101279145B1 (ko) * 2012-08-10 2013-06-26 주식회사 셀루메드 활성형 ｂｍｐ7의 생산율 증가 방법
GB201412290D0 (en) 2014-07-10 2014-08-27 Cambridge Entpr Ltd Novel use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5108901A (en) * 1988-09-02 1992-04-28 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5641649A (en) * 1992-01-27 1997-06-24 Italian Ministry For Universities And Scientific And Technological Research Expression of osteogenic factor OP-1 in cells of spodoptera frugiperda infected with recombinant baculovirus

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE287949T1 (de) * 1992-07-31 2005-02-15 Stryker Corp Löslicher komplex morphogener proteine und zusammensetzungen davon
WO1999003887A1 (fr) * 1997-07-14 1999-01-28 Bolder Biotechnology, Inc. Derives d'hormone de croissance et proteines associees
US20030170213A1 (en) * 1998-01-23 2003-09-11 Marc F. Charette Methods and compositions for enhancing cognitive function using morphogenic proteins
US6677432B1 (en) * 1998-10-07 2004-01-13 Stryker Corporation Mutations of the C-terminal portion of TGF-β superfamily proteins
US7610156B2 (en) * 2003-03-31 2009-10-27 Xencor, Inc. Methods for rational pegylation of proteins
EP1730186A2 (fr) * 2004-03-31 2006-12-13 Xencor, Inc. Variants de bmp-7 ayant des proprietes ameliorees
ATE543833T1 (de) * 2005-12-22 2012-02-15 Janssen Biotech Inc Bmp-7-varianten-zusammensetzungen, verfahren und verwendungen

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5108901A (en) * 1988-09-02 1992-04-28 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5641649A (en) * 1992-01-27 1997-06-24 Italian Ministry For Universities And Scientific And Technological Research Expression of osteogenic factor OP-1 in cells of spodoptera frugiperda infected with recombinant baculovirus

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2056852A4 *

Also Published As

Publication number Publication date
WO2008014054A2 (fr) 2008-01-31
JP2009544325A (ja) 2009-12-17
EP2056852A4 (fr) 2010-01-13
EP2056852A2 (fr) 2009-05-13

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