WO2008013823A3 - Co-crystals of (2r-trans)-6-chloro-5-[[4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-n,n,1-trimethyl-alpha-oxo-1h-indole-3-acetamide - Google Patents

Co-crystals of (2r-trans)-6-chloro-5-[[4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-n,n,1-trimethyl-alpha-oxo-1h-indole-3-acetamide Download PDF

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Publication number
WO2008013823A3
WO2008013823A3 PCT/US2007/016668 US2007016668W WO2008013823A3 WO 2008013823 A3 WO2008013823 A3 WO 2008013823A3 US 2007016668 W US2007016668 W US 2007016668W WO 2008013823 A3 WO2008013823 A3 WO 2008013823A3
Authority
WO
WIPO (PCT)
Prior art keywords
crystals
piperazinyl
acetamide
fluorophenyl
indole
Prior art date
Application number
PCT/US2007/016668
Other languages
French (fr)
Other versions
WO2008013823A2 (en
Inventor
Renato Andres Chiarella
Original Assignee
Scios Inc
Renato Andres Chiarella
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scios Inc, Renato Andres Chiarella filed Critical Scios Inc
Publication of WO2008013823A2 publication Critical patent/WO2008013823A2/en
Publication of WO2008013823A3 publication Critical patent/WO2008013823A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

The present invention relates to novel co-crystals of the Active Pharmaceutical Ingredient (API) (2R-trans)-6-chloro-5-[[4-[(4-fluorophenyl)methyl]-2,5-dimethyl- 1 - piperazinyl]carbonyl]-N,N, l-trimethyl-alpha-oxo-lH-indole-3-acetamide, methods for their preparation, and pharmaceutical compositions comprising the novel co-crystals.
PCT/US2007/016668 2006-07-26 2007-07-25 Co-crystals of (2r-trans)-6-chloro-5-[[4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-n,n,1-trimethyl-alpha-oxo-1h-indole-3-acetamide WO2008013823A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82036906P 2006-07-26 2006-07-26
US60/820,369 2006-07-26

Publications (2)

Publication Number Publication Date
WO2008013823A2 WO2008013823A2 (en) 2008-01-31
WO2008013823A3 true WO2008013823A3 (en) 2008-12-18

Family

ID=38982033

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/016668 WO2008013823A2 (en) 2006-07-26 2007-07-25 Co-crystals of (2r-trans)-6-chloro-5-[[4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-n,n,1-trimethyl-alpha-oxo-1h-indole-3-acetamide

Country Status (1)

Country Link
WO (1) WO2008013823A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2418954B1 (en) 2009-04-16 2013-05-29 Bayer Intellectual Property GmbH Imidacloprid containing co-crystal and method for producing same
EP2493884A1 (en) 2009-10-27 2012-09-05 Bayer Technology Services GmbH Co-crystal of 4-{[(6-chloropyrid-3-yl)methyl](2,2-difluoroethyl)amino}­furan-2(5h)-one with salicylic acid and use thereof as pesticide
US20120283294A1 (en) 2009-10-27 2012-11-08 Bayer Technology Services Gmbh Co-crystal of 4-furan-2(5h)-one with benzoic acid and use thereof as pesticide
CN102712631A (en) 2009-10-27 2012-10-03 拜尔技术服务有限责任公司 Co-crystal of 4-{[(6-chloropyrid-3-yl)methyl](2,2-difluoroethyl)amino}furan-2(5h)-one with oxalic acid and use thereof as pesticide
DE102010039687A1 (en) 2010-08-24 2012-03-01 Bayer Technology Services Gmbh A powder formulation comprising imidacloprid and oxalic acid, and methods of making co-crystals comprising imidacloprid and oxalic acid by compaction
HRP20221196T1 (en) 2017-10-05 2022-12-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040176598A1 (en) * 2002-10-09 2004-09-09 Sundeep Dugar Azaindole derivatives as inhibitors of p38 kinase
US7220763B2 (en) * 2002-09-03 2007-05-22 Scios, Inc. Indole-type derivatives as inhibitors of p38 kinase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7220763B2 (en) * 2002-09-03 2007-05-22 Scios, Inc. Indole-type derivatives as inhibitors of p38 kinase
US20040176598A1 (en) * 2002-10-09 2004-09-09 Sundeep Dugar Azaindole derivatives as inhibitors of p38 kinase

Also Published As

Publication number Publication date
WO2008013823A2 (en) 2008-01-31

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