WO2008013807A3 - A novel lactic acid formulation of mk-0457 useful for the treatment of cancer - Google Patents

A novel lactic acid formulation of mk-0457 useful for the treatment of cancer Download PDF

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Publication number
WO2008013807A3
WO2008013807A3 PCT/US2007/016637 US2007016637W WO2008013807A3 WO 2008013807 A3 WO2008013807 A3 WO 2008013807A3 US 2007016637 W US2007016637 W US 2007016637W WO 2008013807 A3 WO2008013807 A3 WO 2008013807A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer
useful
treatment
lactic acid
acid formulation
Prior art date
Application number
PCT/US2007/016637
Other languages
French (fr)
Other versions
WO2008013807A2 (en
WO2008013807A9 (en
Inventor
David C Dubost
Original Assignee
Merck & Co Inc
David C Dubost
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, David C Dubost filed Critical Merck & Co Inc
Priority to EP07796994A priority Critical patent/EP2051737A2/en
Priority to AU2007277226A priority patent/AU2007277226A1/en
Priority to JP2009521803A priority patent/JP2009544705A/en
Priority to CA002658436A priority patent/CA2658436A1/en
Publication of WO2008013807A2 publication Critical patent/WO2008013807A2/en
Publication of WO2008013807A3 publication Critical patent/WO2008013807A3/en
Publication of WO2008013807A9 publication Critical patent/WO2008013807A9/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Abstract

A lactic acid formulation, and a process to prepare that formulation, of MK-0457 is disclosed:. Such a formulation is useful in the treatment of cancer.
PCT/US2007/016637 2006-07-26 2007-07-24 A novel lactic acid formulation of mk-0457 useful for the treatment of cancer WO2008013807A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP07796994A EP2051737A2 (en) 2006-07-26 2007-07-24 A novel lactic acid formulation of mk-0457 useful for the treatment of cancer
AU2007277226A AU2007277226A1 (en) 2006-07-26 2007-07-24 A novel lactic acid formulation of MK-0457 useful for the treatment of cancer
JP2009521803A JP2009544705A (en) 2006-07-26 2007-07-24 MK-0457 novel lactic acid formulation useful for cancer treatment
CA002658436A CA2658436A1 (en) 2006-07-26 2007-07-24 A novel lactic acid formulation of mk-0457 useful for the treatment of cancer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83344206P 2006-07-26 2006-07-26
US60/833,442 2006-07-26

Publications (3)

Publication Number Publication Date
WO2008013807A2 WO2008013807A2 (en) 2008-01-31
WO2008013807A3 true WO2008013807A3 (en) 2008-04-03
WO2008013807A9 WO2008013807A9 (en) 2009-03-12

Family

ID=38863098

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/016637 WO2008013807A2 (en) 2006-07-26 2007-07-24 A novel lactic acid formulation of mk-0457 useful for the treatment of cancer

Country Status (6)

Country Link
EP (1) EP2051737A2 (en)
JP (1) JP2009544705A (en)
CN (1) CN101500613A (en)
AU (1) AU2007277226A1 (en)
CA (1) CA2658436A1 (en)
WO (1) WO2008013807A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2982890C (en) * 2015-04-17 2023-08-22 Ludwig Institute For Cancer Research Ltd Plk4 inhibitors
WO2017146253A1 (en) 2016-02-26 2017-08-31 公益財団法人がん研究会 Screening method of anticancer agent focused on function of hp1, and evaluation system

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007014250A2 (en) * 2005-07-26 2007-02-01 Vertex Pharmaceuticals Incorporated Abl kinase inhibition
WO2007136615A2 (en) * 2006-05-16 2007-11-29 Merck & Co., Inc. Combination cancer therapy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007014250A2 (en) * 2005-07-26 2007-02-01 Vertex Pharmaceuticals Incorporated Abl kinase inhibition
WO2007136615A2 (en) * 2006-05-16 2007-11-29 Merck & Co., Inc. Combination cancer therapy

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DOGGRELL SHEILA A: "Dawn of Aurora kinase inhibitors as anticancer drugs.", EXPERT OPINION ON INVESTIGATIONAL DRUGS SEP 2004, vol. 13, no. 9, September 2004 (2004-09-01), pages 1199 - 1201, XP002467064, ISSN: 1744-7658 *
HARRINGTON E A ET AL: "VX-680, A Potent and Selective Small-Molecule Inhibitor of the Aurora Kinases, Suppress Tumor Growth In Vivo", NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 10, no. 3, March 2004 (2004-03-01), pages 262 - 267, XP003014821, ISSN: 1078-8956 *
WANG Y ET AL: "VX-680/MK-0457. Aurora kinase inhibitor oncolytic", DRUGS OF THE FUTURE 2007 SPAIN, vol. 32, no. 2, 2007, pages 144 - 147, XP002467063, ISSN: 0377-8282 *

Also Published As

Publication number Publication date
WO2008013807A2 (en) 2008-01-31
WO2008013807A9 (en) 2009-03-12
AU2007277226A1 (en) 2008-01-31
CN101500613A (en) 2009-08-05
EP2051737A2 (en) 2009-04-29
CA2658436A1 (en) 2008-01-31
JP2009544705A (en) 2009-12-17

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