WO2008009970A3 - Process for the preparation of montelukast - Google Patents
Process for the preparation of montelukast Download PDFInfo
- Publication number
- WO2008009970A3 WO2008009970A3 PCT/GB2007/002790 GB2007002790W WO2008009970A3 WO 2008009970 A3 WO2008009970 A3 WO 2008009970A3 GB 2007002790 W GB2007002790 W GB 2007002790W WO 2008009970 A3 WO2008009970 A3 WO 2008009970A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- montelukast
- preparation
- formula
- pharmaceutically acceptable
- acceptable salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Quinoline Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002658473A CA2658473A1 (en) | 2006-07-21 | 2007-07-23 | Process |
EP07766340A EP2046750A2 (en) | 2006-07-21 | 2007-07-23 | Process for the preparation of montelukast |
IL196602A IL196602A0 (en) | 2006-07-21 | 2009-01-20 | Processes for the preparation of montelukast |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0614485.1 | 2006-07-21 | ||
GBGB0614485.1A GB0614485D0 (en) | 2006-07-21 | 2006-07-21 | Process |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008009970A2 WO2008009970A2 (en) | 2008-01-24 |
WO2008009970A3 true WO2008009970A3 (en) | 2008-04-10 |
Family
ID=37081006
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2007/002790 WO2008009970A2 (en) | 2006-07-21 | 2007-07-23 | Process for the preparation of montelukast |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP2046750A2 (en) |
CA (1) | CA2658473A1 (en) |
GB (1) | GB0614485D0 (en) |
IL (1) | IL196602A0 (en) |
WO (1) | WO2008009970A2 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1904448B1 (en) | 2005-07-05 | 2011-02-02 | Teva Pharmaceutical Industries, Ltd. | Purification of montelukast |
EP1886998A1 (en) | 2006-08-09 | 2008-02-13 | Esteve Quimica, S.A. | Purification process of montelukast and its amine salts |
EP2552892A1 (en) | 2010-03-31 | 2013-02-06 | KRKA, D.D., Novo Mesto | Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein |
HUP1000425A2 (en) | 2010-08-11 | 2012-03-28 | Richter Gedeon Nyrt | Process for the production of montelukast sodium |
WO2014081616A1 (en) * | 2012-11-21 | 2014-05-30 | Merck Sharp & Dohme Corp. | Preparation of precursors for leukotriene antagonists |
CN105541711B (en) * | 2016-02-22 | 2018-06-19 | 齐鲁天和惠世制药有限公司 | A kind of preparation method of montelukast |
CN105541710B (en) * | 2016-02-22 | 2018-06-19 | 齐鲁天和惠世制药有限公司 | A kind of synthetic method of montelukast |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0480717A1 (en) * | 1990-10-12 | 1992-04-15 | Merck Frosst Canada Inc. | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists |
EP0737186A1 (en) * | 1993-12-28 | 1996-10-16 | Merck & Co. Inc. | Process for the preparation of leukotriene antagonists |
-
2006
- 2006-07-21 GB GBGB0614485.1A patent/GB0614485D0/en not_active Ceased
-
2007
- 2007-07-23 CA CA002658473A patent/CA2658473A1/en not_active Abandoned
- 2007-07-23 EP EP07766340A patent/EP2046750A2/en not_active Withdrawn
- 2007-07-23 WO PCT/GB2007/002790 patent/WO2008009970A2/en active Application Filing
-
2009
- 2009-01-20 IL IL196602A patent/IL196602A0/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0480717A1 (en) * | 1990-10-12 | 1992-04-15 | Merck Frosst Canada Inc. | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists |
EP0737186A1 (en) * | 1993-12-28 | 1996-10-16 | Merck & Co. Inc. | Process for the preparation of leukotriene antagonists |
Also Published As
Publication number | Publication date |
---|---|
WO2008009970A2 (en) | 2008-01-24 |
CA2658473A1 (en) | 2008-01-24 |
IL196602A0 (en) | 2009-11-18 |
EP2046750A2 (en) | 2009-04-15 |
GB0614485D0 (en) | 2006-09-27 |
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