WO2008006725A1 - Composition - Google Patents

Composition Download PDF

Info

Publication number
WO2008006725A1
WO2008006725A1 PCT/EP2007/056627 EP2007056627W WO2008006725A1 WO 2008006725 A1 WO2008006725 A1 WO 2008006725A1 EP 2007056627 W EP2007056627 W EP 2007056627W WO 2008006725 A1 WO2008006725 A1 WO 2008006725A1
Authority
WO
WIPO (PCT)
Prior art keywords
toothpaste composition
composition according
zinc
chelating agent
opaque
Prior art date
Application number
PCT/EP2007/056627
Other languages
English (en)
Inventor
Victoria Cromwell
Philip Christopher Waterfield
Original Assignee
Unilever Plc
Unilever N.V.
Hindustan Unilever Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever Plc, Unilever N.V., Hindustan Unilever Limited filed Critical Unilever Plc
Priority to EP07765752A priority Critical patent/EP2046454A1/fr
Priority to BRPI0711979-8A priority patent/BRPI0711979A2/pt
Publication of WO2008006725A1 publication Critical patent/WO2008006725A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A61K8/21—Fluorides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention relates to an opaque toothpaste composition comprising bioactive zinc salts in a chalk formulation.
  • the invention also relates to a method for making said composition.
  • EP-Al-O 740 932 discloses a visually-clear gel type dentifrice comprising a zinc salt which is more water soluble than zinc citrate, an amino acid which can bind zinc and a low refractive index type abrasive silica.
  • US 5 470 561 discloses an anti-plaque mouthwash comprising a zinc salt and triclosan.
  • the composition may also comprise glycine and has a pH of between 4 and 8, preferably between 5 and 7, the preferred pH being 6.
  • GBA-2 052 978 discloses a toothpaste comprising zinc salts with glycine and a pH of from 4.5 to 8.0.
  • US 5 632 972 discloses a method for minimising damage to gingival and periodontal tissue by delivering a first component comprising zinc and a second component comprising a bicarbonate.
  • US 4 425 325 discloses an oral composition containing biologically active zinc ions with glycine and having an adjusted pH of about 4.5 to 9.4.
  • GB 1 319 247 discloses a non-liquid anticalculus dental composition
  • a dental vehicle discloses a non-liquid anticalculus dental composition
  • a zinc, cupric or zirconium complex of a fluorinated ⁇ - diketone discloses a non-liquid anticalculus dental composition
  • a dental vehicle discloses a non-liquid anticalculus dental composition
  • a zinc, cupric or zirconium complex of a fluorinated ⁇ - diketone discloses a non-liquid anticalculus dental composition
  • US 4 325 939 discloses an alkali metal or ammonium zinc citrate prepared for use in dental compositions and especially in mouthwash compositions.
  • compositions such as dentifrices comprising a mixture of a stannous salt such as stannous fluoride or stannous pyrophosphate and a zinc salt such as zinc citrate.
  • an opaque toothpaste composition according to claim 1.
  • the monofluorophosphate salt provides flurode ion to the toothpaste composition, the fluoride ion is an effective anti-caries agent.
  • monofluorophosphate salts are not stable in chalk-containing toothpastes and so a stabilising agent is required. While trisodium phosphate
  • TSP Tin oxide
  • Zinc phosphate is not a good source of bioavailable zinc. Therefore, by incorporating a chelating agent for the zinc the levels of monofluorophosphate, and also zinc can be maintained after prolonged storage.
  • the zinc salt is present at from 0.01 to 5% by weight of the toothpaste composition, preferably from 0.5 to 3.0% by weight of the composition.
  • the log K 3 I of the chelating ligand with the zinc ion is equal to or greater than the log K 3 I of the acid anion and the zinc ion of the sparingly soluble zinc salt.
  • water soluble zinc salts are preferred. Suitable zinc salts include zinc chloride, zinc sulphate and zinc fluoride. The preferred zinc salt is zinc sulphate which, in this type of formulation, provides the optimum balance as described above .
  • the alkali metal is preferably potassium or sodium, most preferably sodium.
  • the alkali metal phosphate is preferably a mono, di- or tri- phosphate salt, most preferably a triphosphate.
  • the chelating agent for the zinc salt has a log K 3 I of from 4.0 to 6.0.
  • the log K 3 I is the logarithm of the primary Stability Constant which is the binding affinity for a particular ligand with a particular metal ion, in the present invention zinc.
  • the chelating agent is present at from 0.001 to 6% by weight of the composition, preferably at from 0.5 to 4.0% by weight of the composition.
  • Preferred chelating agents include alkali metal salts of citric acid, alanine, glycine and serine. The most preferred are the alkali metal salts of citric acid, especially potassium citrate and most preferably tri-potassium citrate, which provides an optimal balance between being able to protect the zinc salt from hydrolysis (leading to the formation of carbon dioxide) in the chalk system and keeping it soluble and bioavailable .
  • the abrasive system is present at from 10 to 70% by weight of the toothpaste composition, preferably at from 20 to 60% and most preferably at from 35 to 45% by weight of the toothpaste composition.
  • the alkali metal phosphate is present at from 0.01 to 2% by weight, preferably from 0.15 to 1% and especially preferably from 0.2 to 0.5% by weight of the composition.
  • the abrasive system employed in the present invention is calcium carbonate based. This does not prevent the use of non-calcium carbonate abrasives in addition, such as silicas, tungsten carbide and silicon carbide.
  • the abrasive system comprises at least 50% by weight calcium carbonate, more preferably at least 75% by weight calcium carbonate and most preferably at least 95% by weight calcium carbonate. In the most preferred embodiment of the present invention the abrasive system comprises 100% by weight calcium carbonate although mixtures of calcium carbonate and additional abrasives are possible.
  • Preferred calcium carbonates include fine ground natural chalk since it has a surprising stability with regard to its interactivity with zinc salts.
  • fine ground natural chalk FGNC
  • FGNC fine ground natural chalk
  • suitable examples of such are disclosed in US 2003/0072721 Al (Riley) the contents of which with regards to the definition, types and grades of FGNC are incorporated herein by reference.
  • FGNC is meant chalk which is obtained by milling limestone or marble deposits.
  • the FGNC comprises particulate matter of weight-based median particle size ranging from 1 to 15 ⁇ m and BET surface area ranging from 0.5 to 3 m 2 /g.
  • composition according to the invention also preferably comprises a fluoride ion source such as an alkali metal salt of monofluorophosphate, preferably sodium monofluorophosphate .
  • a fluoride ion source such as an alkali metal salt of monofluorophosphate, preferably sodium monofluorophosphate .
  • Such fluoride ion source will be present at such an amount to provide free fluoride ion at from 100 to 2000 ppm, preferably from 900 to 1500 ppm.
  • the toothpaste composition according to the invention comprise further ingredients which are common in the art, such as :
  • antimicrobial agents e.g. chlorhexidine, sanguinarine extract, metronidazole, quaternary ammonium compounds, such as cetylpyridinium chloride; bis-guanides, such as chlorhexidine digluconate, hexetidine, octenidine, alexidine; and halogenated bisphenolic compounds, such as 2,2' methylenebis- (4-chloro-6-bromophenol) ;
  • anti-inflammatory agents such as ibuprofen, flurbiprofen, aspirin, indomethacin etc.;
  • anti-caries agents such as sodium- and stannous fluoride, aminefluorides, sodium monofluorophosphate, sodium trimeta phosphate and casein;
  • plaque buffers such as urea, calcium lactate, calcium glycerophosphate and strontium polyacrylates
  • vitamins such as Vitamins A, C and E;
  • desensitising agents e.g. potassium citrate, potassium chloride, potassium tartrate, potassium bicarbonate, potassium oxalate, potassium nitrate and strontium salts;
  • anti-calculus agents e.g. alkali-metal pyrophosphates, hypophosphite-containing polymers, organic phosphonates and phosphocitrates etc.;
  • biomolecules e.g. bacteriocins, antibodies, enzymes, etc.
  • flavours e.g. peppermint and spearmint oils
  • proteinaceous materials such as collagen; preservatives ; opacifying agents;
  • pharmaceutically acceptable carriers e.g. starch, sucrose, water or water/alcohol systems etc.;
  • surfactants such as anionic, nonionic, cationic and zwitterionic or amphoteric surfactants
  • particulate abrasive materials such as silicas, aluminas, calcium carbonates, dicalciumphosphates, calcium pyrophosphates, hydroxyapatites, trimetaphosphates, insoluble hexametaphosphates and so on, including agglomerated particulate abrasive materials, usually in amounts between 3 and 60% by weight of the toothpaste composition.
  • Preferred abrasives are chalk and silica, more preferably fine ground natural chalk.
  • Humectants such as glycerol, sorbitol, propyleneglycol, xylitol, lactitol etc.;
  • binders and thickeners such as sodium carboxymethyl- cellulose, hydroxyethyl cellulose (Natrosol®) , xanthan gum, gum arabic etc. as well as synthetic polymers such as polyacrylates and carboxyvinyl polymers such as Carbopol®; polymeric compounds which can enhance the delivery of active ingredients such as antimicrobial agents can also be included;
  • bleaching agents such as peroxy compounds e.g. potassium peroxydiphosphate, effervescing systems such as sodium bicarbonate/citric acid systems, colour change systems, and so on .
  • Liposomes may also be used to improve delivery or stability of active ingredients.
  • a method of making an opaque toothpaste composition comprising the steps of forming a zinc-chelate solution and buffering to a pH which is equal to or higher than that of the calcium carbonate in an aqueous suspension before mixing with the suspended calcium carbonate. Further materials such as flavours may be added to the final mix.
  • the following example formulation is an embodiment according to the invention. It is made by mixing first the zinc sulphate heptahydrate with glycine (and other minors) and buffering to a pH of from 8.5 to 9.5 with sodium hydroxide. The calcium carbonate, surfactant and structurants are then added to the zinc-chelate mix. The flavours are added last.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne une composition de pâte dentifrice opaque qui comprend : de l'eau ; un sel de zinc ; un agent chélatant du sel de zinc, l'agent chélatant ayant un log Ks1 tel que défini ici compris entre 3,0 et 7,0 ; du carbonate de calcium représentant de 10 à 70 % en masse de la composition de pâte dentifrice ; un sel monofluorophosphate ; et un phosphate trisodique.
PCT/EP2007/056627 2006-07-13 2007-07-02 Composition WO2008006725A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP07765752A EP2046454A1 (fr) 2006-07-13 2007-07-02 Composition pour dentifrice
BRPI0711979-8A BRPI0711979A2 (pt) 2006-07-13 2007-07-02 composição de dentifrìcio opaca, dentrifìcio opaco e método de produção

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06117088.2 2006-07-13
EP06117088 2006-07-13

Publications (1)

Publication Number Publication Date
WO2008006725A1 true WO2008006725A1 (fr) 2008-01-17

Family

ID=37546780

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/056627 WO2008006725A1 (fr) 2006-07-13 2007-07-02 Composition

Country Status (4)

Country Link
EP (1) EP2046454A1 (fr)
CN (1) CN101489628A (fr)
BR (1) BRPI0711979A2 (fr)
WO (1) WO2008006725A1 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010060653A2 (fr) 2008-11-27 2010-06-03 Amc Abrasives Marketing & Consulting Llp Produits de soin dentaire avec des particules de diamant
WO2011053273A1 (fr) 2009-10-26 2011-05-05 Colgate-Palmolive Company Composition buccale pour traitement de la mauvaise haleine
JP2014105191A (ja) * 2012-11-28 2014-06-09 Lion Corp 不透明歯磨剤組成物
WO2014056824A3 (fr) * 2012-10-12 2014-10-09 Unilever N.V. Composition de soins de bouche
WO2015094836A1 (fr) * 2013-12-19 2015-06-25 Colgate-Palmolive Company Composition de soin buccal comprenant de la sérine et au moins un sel de zinc
CN104837469A (zh) * 2012-10-12 2015-08-12 荷兰联合利华有限公司 口腔护理组合物
RU2636221C2 (ru) * 2012-12-24 2017-11-21 Колгейт-Палмолив Компани Композиция для ухода за полостью рта
RU2670445C2 (ru) * 2014-06-18 2018-10-23 Колгейт-Палмолив Компани Средство для ухода за зубами, содержащее комплекс цинка с аминокислотой и фосфаты
WO2023225256A1 (fr) * 2022-05-20 2023-11-23 The Procter & Gamble Company Composition d'hygiène buccale comprenant un opacifiant
WO2023225255A1 (fr) * 2022-05-20 2023-11-23 The Procter & Gamble Company Composition de soins bucco-dentaires comprenant un opacifiant

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4283385A (en) * 1980-05-09 1981-08-11 Richardson-Merrell Inc. Dentifrices with improved soluble fluoride availability
WO1997006774A1 (fr) * 1995-08-08 1997-02-27 Enamelon, Inc. Produits et procedes de remineralisation des dents
US5616313A (en) * 1994-06-30 1997-04-01 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Method for treating gingival and periodontal tissues
US5624906A (en) * 1994-12-08 1997-04-29 Lever Brothers Company, Division Of Conopco, Inc. Oral hygiene compositions comprising heteroatom containing alkyl aldonamide compounds
US20030026768A1 (en) * 1999-04-08 2003-02-06 Dahshen Yu Dentifrice compositions having reduced abrasivity
WO2003017964A1 (fr) * 2001-08-24 2003-03-06 Unilever N.V. Composition orale comprenant un hydroxybenzoate d'alkyle

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4283385A (en) * 1980-05-09 1981-08-11 Richardson-Merrell Inc. Dentifrices with improved soluble fluoride availability
US5616313A (en) * 1994-06-30 1997-04-01 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Method for treating gingival and periodontal tissues
US5624906A (en) * 1994-12-08 1997-04-29 Lever Brothers Company, Division Of Conopco, Inc. Oral hygiene compositions comprising heteroatom containing alkyl aldonamide compounds
WO1997006774A1 (fr) * 1995-08-08 1997-02-27 Enamelon, Inc. Produits et procedes de remineralisation des dents
US20030026768A1 (en) * 1999-04-08 2003-02-06 Dahshen Yu Dentifrice compositions having reduced abrasivity
WO2003017964A1 (fr) * 2001-08-24 2003-03-06 Unilever N.V. Composition orale comprenant un hydroxybenzoate d'alkyle

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010060653A2 (fr) 2008-11-27 2010-06-03 Amc Abrasives Marketing & Consulting Llp Produits de soin dentaire avec des particules de diamant
US8883178B2 (en) 2008-11-27 2014-11-11 Amc Abrasives Marketing & Consulting Llp Dental care products with diamond particles
CN105232344A (zh) * 2009-10-26 2016-01-13 高露洁-棕榄公司 治疗口臭的口腔用组合物
WO2011053273A1 (fr) 2009-10-26 2011-05-05 Colgate-Palmolive Company Composition buccale pour traitement de la mauvaise haleine
AU2009354829B2 (en) * 2009-10-26 2013-03-07 Colgate-Palmolive Company Oral composition for treating oral malodor
CN105232344B (zh) * 2009-10-26 2020-10-02 高露洁-棕榄公司 治疗口臭的口腔用组合物
EA027276B1 (ru) * 2012-10-12 2017-07-31 Юнилевер Н.В. Композиция для ухода за полостью рта
CN104837469B (zh) * 2012-10-12 2017-09-26 荷兰联合利华有限公司 口腔护理组合物
CN104837469A (zh) * 2012-10-12 2015-08-12 荷兰联合利华有限公司 口腔护理组合物
WO2014056824A3 (fr) * 2012-10-12 2014-10-09 Unilever N.V. Composition de soins de bouche
JP2014105191A (ja) * 2012-11-28 2014-06-09 Lion Corp 不透明歯磨剤組成物
US10064794B2 (en) 2012-12-24 2018-09-04 Colgate-Palmolive Company Oral care composition
RU2636221C2 (ru) * 2012-12-24 2017-11-21 Колгейт-Палмолив Компани Композиция для ухода за полостью рта
AU2014366478B2 (en) * 2013-12-19 2017-03-02 Colgate-Palmolive Company Oral care composition comprising serine and at least a zinc salt
US10576032B2 (en) 2013-12-19 2020-03-03 Colgate-Palmolive Company Oral care composition comprising serine and at least a zinc salt
WO2015094836A1 (fr) * 2013-12-19 2015-06-25 Colgate-Palmolive Company Composition de soin buccal comprenant de la sérine et au moins un sel de zinc
RU2670445C2 (ru) * 2014-06-18 2018-10-23 Колгейт-Палмолив Компани Средство для ухода за зубами, содержащее комплекс цинка с аминокислотой и фосфаты
US10130571B2 (en) 2014-06-18 2018-11-20 Colgate-Palmolive Company Dentifrice Comprising Zinc-Amino Acid Complex and Phosphates
US10561590B2 (en) 2014-06-18 2020-02-18 Colgate-Palmolive Company Dentifrice compromising zinc-amino acid complex and phosphates
WO2023225256A1 (fr) * 2022-05-20 2023-11-23 The Procter & Gamble Company Composition d'hygiène buccale comprenant un opacifiant
WO2023225255A1 (fr) * 2022-05-20 2023-11-23 The Procter & Gamble Company Composition de soins bucco-dentaires comprenant un opacifiant

Also Published As

Publication number Publication date
EP2046454A1 (fr) 2009-04-15
CN101489628A (zh) 2009-07-22
BRPI0711979A2 (pt) 2012-01-17

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