WO2008002199A2 - Clathrate de 1,6,3,8-diméthano-tétra-aza-cyclodécane / carbonate de sodium comme produit biocide et virucide - Google Patents

Clathrate de 1,6,3,8-diméthano-tétra-aza-cyclodécane / carbonate de sodium comme produit biocide et virucide Download PDF

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Publication number
WO2008002199A2
WO2008002199A2 PCT/RU2007/000342 RU2007000342W WO2008002199A2 WO 2008002199 A2 WO2008002199 A2 WO 2008002199A2 RU 2007000342 W RU2007000342 W RU 2007000342W WO 2008002199 A2 WO2008002199 A2 WO 2008002199A2
Authority
WO
WIPO (PCT)
Prior art keywords
biocidal
clathrate
sodium carbonate
dimethano
agent
Prior art date
Application number
PCT/RU2007/000342
Other languages
English (en)
Russian (ru)
Other versions
WO2008002199A3 (fr
Inventor
Yevgeny Yakovlevich Demyashkin
Original Assignee
Aichinger, Elena
Aichinger, Markus
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aichinger, Elena, Aichinger, Markus filed Critical Aichinger, Elena
Publication of WO2008002199A2 publication Critical patent/WO2008002199A2/fr
Publication of WO2008002199A3 publication Critical patent/WO2008002199A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases

Definitions

  • the invention relates to the field of sanitation, veterinary medicine, agricultural chemistry, cosmetics, food industry and household chemicals, and relates to the development of an environmentally friendly biocidal and virucidal agent with anticorrosive properties, and its use for disinfection from pathogenic viruses, bacteria, protozoa and fungi premises, equipment, inventory, tools, instruments, utensils, cosmetics, animals, food, feed, soil and other objects of sanitary supervision.
  • Disinfection can be carried out by irrigation, immersion, watering, aerosol method, including in the presence of animals and people.
  • Hot solutions should have a temperature not lower than 70 0 C, and solutions of soda ash not lower than 90 0 C. If disinfection is carried out by an aerosol method, then apply: 6% hydrogen peroxide solution, formalin-creolin mixture or formalin (36-40% - aqueous formaldehyde solution) (Veterinary law. -M .: Kolos, 1973 vol. 2, p. 399 - 418.).
  • the active principle is aggressive toxic gases, such as chlorine, formaldehyde, atomic oxygen, etc., which can create explosive mixtures, destroy polymeric materials, protective coatings, corrode metals, lead to emergencies and poisoning animals and people. This makes disinfection in the presence of animals and people dangerous and practically impossible.
  • Solutions of many disinfectants are electrolytes that cause corrosion of metal surfaces, aggregates, their parts and assemblies. Aggressive gases released during disinfection cause discoloration of pigments and changes in the structure of organic polymers, causing damage to objects that have protective or insulating coatings of paint and varnish and polymer organic compounds.
  • the technical result of the proposed invention is to increase the biocidal and virucidal activity of the agent.
  • Disinfection with solutions of clathrate l, 6,3,8-dimethano-l, 3,6,8- sodium tetraazacyclodecane-carbonate provides the following: no toxicity to humans and animals, no unpleasant odor and irritating effect on the skin and mucous membranes, anti-corrosion properties and no aggressive effect on paints and synthetic polymeric materials and coatings, partial sublimation, water solubility and stability aqueous solutions over a wide range of temperatures, a pronounced bactericidal and virucidal effect in a temperature range from 0 0 C to +40 0 C, the opportunities of s disinfection in the presence of birds and animals.
  • clathrate l, 6,3,8-dimethano-l, 3,6,8-tetraazacyclodecane-sodium carbonate is carried out from N 5 N'-di (chloromethyl) -l, 2-diaminoethane by mixing solutions of N 5 N'-di ( chloro-methyl) -l, 2-diaminoethane and sodium carbonate in equivalent proportions. It can also be carried out from 1,6,3,8-dimethano-l, 3,6,8-tetrazacicyclo decane by mixing solutions of 1,6,3, 8-dimethano-l, 3,6,8-tetrazacicyclodecane and sodium carbonate in equivalent ratios.
  • the partial sublimation temperature is about 165 ° C at 760 mm Hg.
  • the chemical name is clathrate l, 6,3,8-dimethano-l, 3,6,8-tetraazacyclodecane-sodium carbonate.
  • MBC minimum bactericidal concentration
  • LD 50 the dose at which 50% of white mice die
  • LD 5 o sodium chloride - 3000 mg / kg the dose at which 50% of white mice die
  • food ethyl alcohol - 2080 mg / kg the dose at which 50% of white mice die
  • caffeine - 192 mg / kg the dose at which 50% of white mice die
  • LD 5 o prototype 1,6,3, 8-dimethano-3, 3, 6.8-tetraazacyclododecane - 2092 mg / kg.
  • Clathrate 1,6,3,8-dimethano-l, 3,6,8-tetrazacicyclodecane sodium carbonate is a domestic product, is synthesized from the raw materials produced in the country and retains disinfectant properties in aqueous solutions for at least 180 days (observation period).

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Dentistry (AREA)
  • Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Inorganic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

L'invention appartient aux domaines sanitaire, vétérinaire et médical et concerne le développement d'un produit biocide et virucide anti-corrosif, technologique et sûr du point de vue de l'environnement, destiné à la désinfection de la vaisselle, des instruments, des dispositifs,des produits cosmétiques, des animaux, des fourrages, des sols, des locaux, des équipements ou d'autres sites et objets sous surveillance sanitaire, par l'élimination des virus pathogènes, de protozoaires et de champignons. Pour améliorer la sécurité écologique ainsi que l'activité biocide et virucide on utilise la composition de clathrate de 1,6,3,8-diméthano-tétra-aza-cyclodécane / carbonate de sodium possédant la formule structurelle et présentant une activité biocide et virucide.
PCT/RU2007/000342 2006-06-23 2007-06-22 Clathrate de 1,6,3,8-diméthano-tétra-aza-cyclodécane / carbonate de sodium comme produit biocide et virucide WO2008002199A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2006122384 2006-06-23
RU2006122384 2006-06-23

Publications (2)

Publication Number Publication Date
WO2008002199A2 true WO2008002199A2 (fr) 2008-01-03
WO2008002199A3 WO2008002199A3 (fr) 2008-02-14

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2007/000342 WO2008002199A2 (fr) 2006-06-23 2007-06-22 Clathrate de 1,6,3,8-diméthano-tétra-aza-cyclodécane / carbonate de sodium comme produit biocide et virucide

Country Status (1)

Country Link
WO (1) WO2008002199A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010087739A1 (fr) * 2009-01-27 2010-08-05 Demyashkin Evgeny Yakovlevich Agent antiseptique sous forme d'un hydrate cristallin de 1,6,3,8-diméthane-1,6,3,8-tétraazacyclodécane-carbonate de sodium
US8530214B2 (en) 2003-01-28 2013-09-10 Cellectis S.A. Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof
US8927247B2 (en) 2008-01-31 2015-01-06 Cellectis, S.A. I-CreI derived single-chain meganuclease and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2123337C1 (ru) * 1997-03-20 1998-12-20 Всероссийский научно-исследовательский институт ветеринарной вирусологии и микробиологии Препарат "теотропин" для дезинфекции объектов санитарного надзора
RU2265451C2 (ru) * 2003-08-20 2005-12-10 Всероссийский научно-исследовательский институт птицеводства Способ получения средства для профилактики респираторного микоплазмоза птиц и способ профилактики
RU2273495C1 (ru) * 2004-11-24 2006-04-10 Всероссийский научно-исследовательский институт ветеринарной санитарии, гигиены и экологии Дезинфицирующее средство-"дезант"

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2123337C1 (ru) * 1997-03-20 1998-12-20 Всероссийский научно-исследовательский институт ветеринарной вирусологии и микробиологии Препарат "теотропин" для дезинфекции объектов санитарного надзора
RU2265451C2 (ru) * 2003-08-20 2005-12-10 Всероссийский научно-исследовательский институт птицеводства Способ получения средства для профилактики респираторного микоплазмоза птиц и способ профилактики
RU2273495C1 (ru) * 2004-11-24 2006-04-10 Всероссийский научно-исследовательский институт ветеринарной санитарии, гигиены и экологии Дезинфицирующее средство-"дезант"

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8530214B2 (en) 2003-01-28 2013-09-10 Cellectis S.A. Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof
US8624000B2 (en) 2003-01-28 2014-01-07 Cellectis S.A. Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof
US8697395B2 (en) 2003-01-28 2014-04-15 Cellectis S.A. Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof
US8927247B2 (en) 2008-01-31 2015-01-06 Cellectis, S.A. I-CreI derived single-chain meganuclease and uses thereof
WO2010087739A1 (fr) * 2009-01-27 2010-08-05 Demyashkin Evgeny Yakovlevich Agent antiseptique sous forme d'un hydrate cristallin de 1,6,3,8-diméthane-1,6,3,8-tétraazacyclodécane-carbonate de sodium

Also Published As

Publication number Publication date
WO2008002199A3 (fr) 2008-02-14

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