WO2008001278A3 - Extracts of plectranthus hadiensis, argenatus or myrianthus for the treatment of microbial infection - Google Patents

Extracts of plectranthus hadiensis, argenatus or myrianthus for the treatment of microbial infection Download PDF

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Publication number
WO2008001278A3
WO2008001278A3 PCT/IB2007/052375 IB2007052375W WO2008001278A3 WO 2008001278 A3 WO2008001278 A3 WO 2008001278A3 IB 2007052375 W IB2007052375 W IB 2007052375W WO 2008001278 A3 WO2008001278 A3 WO 2008001278A3
Authority
WO
WIPO (PCT)
Prior art keywords
myrianthus
plectranthus
treatment
microbial infection
argenatus
Prior art date
Application number
PCT/IB2007/052375
Other languages
French (fr)
Other versions
WO2008001278A2 (en
Inventor
Mark Delmege Laing
Siegfried E Drewes
Prenitha Gurlal
Original Assignee
Univ Kwazulu Natal
Mark Delmege Laing
Siegfried E Drewes
Prenitha Gurlal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Kwazulu Natal, Mark Delmege Laing, Siegfried E Drewes, Prenitha Gurlal filed Critical Univ Kwazulu Natal
Publication of WO2008001278A2 publication Critical patent/WO2008001278A2/en
Publication of WO2008001278A3 publication Critical patent/WO2008001278A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Abstract

The invention provides the use of a compound of the general formula (1 ) including stereoisomers thereof wherein R1 is R2 CO; and R2 -R6 are selected from H, lower alkyl, or lower alkenyl, in the manufacture of a medicament for the treatment of a microbial infection. The compound of formula (1 ) may be obtained from a plant selected from Plectranthus hadiensis, Plectranthus argentatus and Plectranthus myrianthus.
PCT/IB2007/052375 2006-06-30 2007-06-20 Extracts of plectranthus hadiensis, argenatus or myrianthus for the treatment of microbial infection WO2008001278A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ZA200605446 2006-06-30
ZA2006/05446 2006-06-30

Publications (2)

Publication Number Publication Date
WO2008001278A2 WO2008001278A2 (en) 2008-01-03
WO2008001278A3 true WO2008001278A3 (en) 2008-05-15

Family

ID=38846058

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/052375 WO2008001278A2 (en) 2006-06-30 2007-06-20 Extracts of plectranthus hadiensis, argenatus or myrianthus for the treatment of microbial infection

Country Status (1)

Country Link
WO (1) WO2008001278A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101752233B1 (en) 2015-07-06 2017-06-29 한국생명공학연구원 Compositions containing extracts of Plectranthus hadiensis var. tomentosus (Benth. ex E. Mey.) Codd, fractions or isolated compounds isolated therefrom for prevention and treatment of allergy

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002070638A2 (en) * 2001-02-20 2002-09-12 Sabinsa Corporation Essential oil from.coleus forskohlii, production process and use as antimicrobial agent

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002070638A2 (en) * 2001-02-20 2002-09-12 Sabinsa Corporation Essential oil from.coleus forskohlii, production process and use as antimicrobial agent

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
"The chemical composition and microbial properties of South African Plectranthus (Lamiaceae) species", SOUTH AFRICAN JOURNAL OF BOTANY, 2003, XP009095816 *
ALDER A C ET AL: "POLAR DITERPENOIDS FROM LEAF-GLANDS OF PLECTRANTHUS-ARGENTATUS", HELVETICA CHIMICA ACTA, vol. 67, no. 6, 1984, pages 1523 - 1530, XP002468693, ISSN: 0018-019X *
C., W. LUKHOBA; M., S.J. SIMMONDS; A., J. PATON: "Plectranthus: A review of ethnobotanical uses", JOURNAL OF ETHNOPHARMACOLOGY, vol. 103, 2006, pages 1 - 24, XP002468692 *
GASPAR-MARQUES ET AL: "Abietanes from Plectranthus grandidentatus and P. hereroensis against methicillin- and vancomycin-resistant bacteria", PHYTOMEDICINE, GUSTAV FISCHER VERLAG, STUTTGART, DE, vol. 13, no. 4, 13 March 2006 (2006-03-13), pages 267 - 271, XP005299729, ISSN: 0944-7113 *
MEHROTRA R ET AL: "ABIETANE DITERPENOIDS FROM COLEUS-ZEYLANICUS", PHYTOCHEMISTRY (OXFORD), vol. 28, no. 11, 1989, pages 3135 - 3137, XP002468691, ISSN: 0031-9422 *
TEIXEIRA A P ET AL: "Abietane diterpenoids from Plectranthus grandidentatus", PHYTOCHEMISTRY, PERGAMON PRESS, GB, vol. 44, no. 2, January 1997 (1997-01-01), pages 325 - 327, XP004292792, ISSN: 0031-9422 *
TOSHIO MIYASE ET AL: "Diterpenoide Dr}senfarbstoffe aus Labiaten: Coleone U,V,W und 14-O-Formyl-coleon-V sowie 2 Royleanone aus Plectranthus myrianthus BRIQ; cis- und trans-A/B-6,7-Dioxoroyleanon", HELVETICA CHIMICA ACTA, VERLAG HELVETICA CHIMICA ACTA. BASEL, CH, vol. 60, no. 8, 1977, pages 2770 - 2779, XP009095790, ISSN: 0018-019X *
WELLSOW ET AL: "Insect-antifeedant and antibacterial activity of diterpenoids from species of Plectranthus", PHYTOCHEMISTRY, PERGAMON PRESS, GB, vol. 67, no. 16, August 2006 (2006-08-01), pages 1818 - 1825, XP005612177, ISSN: 0031-9422 *

Also Published As

Publication number Publication date
WO2008001278A2 (en) 2008-01-03

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