WO2007003944A3 - Compounds for imaging and therapy - Google Patents

Compounds for imaging and therapy Download PDF

Info

Publication number
WO2007003944A3
WO2007003944A3 PCT/GB2006/002488 GB2006002488W WO2007003944A3 WO 2007003944 A3 WO2007003944 A3 WO 2007003944A3 GB 2006002488 W GB2006002488 W GB 2006002488W WO 2007003944 A3 WO2007003944 A3 WO 2007003944A3
Authority
WO
WIPO (PCT)
Prior art keywords
therapy
imaging
compounds
iii
useful
Prior art date
Application number
PCT/GB2006/002488
Other languages
French (fr)
Other versions
WO2007003944A2 (en
Inventor
Jonathan Robin Dilworth
Josephine Mary Peach
Julia May Heslop
Paul Stephen Donnelly
Original Assignee
Isis Innovation
Jonathan Robin Dilworth
Josephine Mary Peach
Julia May Heslop
Paul Stephen Donnelly
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Innovation, Jonathan Robin Dilworth, Josephine Mary Peach, Julia May Heslop, Paul Stephen Donnelly filed Critical Isis Innovation
Priority to US11/988,230 priority Critical patent/US8299285B2/en
Publication of WO2007003944A2 publication Critical patent/WO2007003944A2/en
Publication of WO2007003944A3 publication Critical patent/WO2007003944A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C07D213/77—Hydrazine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances

Abstract

A metal complex of formula (III) wherein: M is a transition metal and Al, A2, X, X', Y, Ll', Rl' and R2' are as defined herein, is useful in medical imaging and therapy.
PCT/GB2006/002488 2005-07-05 2006-07-05 Compounds for imaging and therapy WO2007003944A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/988,230 US8299285B2 (en) 2005-07-05 2006-07-05 Compounds for imaging and therapy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0513812.8 2005-07-05
GBGB0513812.8A GB0513812D0 (en) 2005-07-05 2005-07-05 Compounds for imaging and therapy

Publications (2)

Publication Number Publication Date
WO2007003944A2 WO2007003944A2 (en) 2007-01-11
WO2007003944A3 true WO2007003944A3 (en) 2007-05-18

Family

ID=34856730

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/002488 WO2007003944A2 (en) 2005-07-05 2006-07-05 Compounds for imaging and therapy

Country Status (3)

Country Link
US (1) US8299285B2 (en)
GB (1) GB0513812D0 (en)
WO (1) WO2007003944A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104212841A (en) * 2014-08-22 2014-12-17 浙江工业大学 Method for preparing (R)-3,5-bis(trifluoromethyl)phenethyl alcohol in ionic liquid-containing cosolvent medium

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10413554B2 (en) 2006-11-20 2019-09-17 The University Of Melbourne Metal delivery agents and therapeutic uses of the same
WO2008061306A1 (en) * 2006-11-20 2008-05-29 The University Of Melbourne Metal delivery agents and therapeutic uses of the same
CA2746070C (en) * 2008-12-12 2017-01-10 The University Of Melbourne Process for the preparation of asymmetrical bis(thiosemicarbazones)
US10517964B2 (en) 2011-02-28 2019-12-31 The Board Of Trustees Of The Leland Stanford Junior University Optical imaging probes, optical imaging systems, methods of optical imaging, and methods of using optical imaging probes
EP2838880B1 (en) 2012-04-17 2017-12-13 Merrimack Pharmaceuticals, Inc. Compositions and methods for non-invasive imaging
CN103254266B (en) * 2013-05-19 2016-04-13 广西师范学院 Steroidal zinc metal complexes and preparation method thereof and the application in the anti-gastric cancer medicament of preparation
US9422286B2 (en) 2014-01-27 2016-08-23 Washington University Metal-binding bifunctional compounds as diagnostic agents for Alzheimer's disease
WO2017049529A1 (en) 2015-09-24 2017-03-30 Innolife Co., Ltd. A pharmaceutical composition comprising a copper chelating tetramine and the use thereof
BR112019011211A2 (en) 2016-12-16 2019-10-15 Basf Se compounds of formula I, composition, methods for combating or controlling invertebrate pests, for protecting growing plants from invertebrate pest attack or infestation, seed, use of a compound and method for treating or protecting an animal
KR101836463B1 (en) 2017-01-25 2018-03-08 경북대학교 산학협력단 MRI contrast agent comprising manganese complex
KR102304622B1 (en) * 2018-05-10 2021-09-24 (주)미래바이오팜 Novel compound, complex comprising the compound, pharmaceutical composition for anti-cancer and anti-cancer agent
CN109694391B (en) * 2018-12-20 2021-03-23 广西师范大学 Platinum complex taking 2-amino-5-chlorobenzophenone thiosemicarbazone as ligand and synthetic method and application thereof
JP2022547638A (en) * 2019-09-03 2022-11-14 プロサイプラ セラピューティクス， エルエルシー Novel polymorphs and their uses
KR102255717B1 (en) * 2019-12-31 2021-05-25 (주)미래바이오팜 Oral pharmaceutical composition for treating liver cancer

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3483207A (en) * 1966-02-19 1969-12-09 Hoechst Ag Unsymmetrical bis-thiosemicarbazones
US3674873A (en) * 1964-07-23 1972-07-04 Burroughs Wellcome Co Method of treating or preventing coccidiosis
US3792052A (en) * 1969-11-18 1974-02-12 May & Baker Ltd Hydrazinecarbodithioate derivatives and metal chelates thereof
GB1448295A (en) * 1974-05-01 1976-09-02 Farmaceutici Italia Thiosemicarbazones
EP0306168A1 (en) * 1987-08-12 1989-03-08 Immunomedics, Inc. Preparation of radiolabeled conjugates
WO1992007860A2 (en) * 1990-10-29 1992-05-14 Mallinckrodt Medical, Inc. TECHNETIUM-99m COMPLEXES FOR USE AS RADIOPHARMACEUTICALS
EP0606683A2 (en) * 1993-01-13 1994-07-20 INSTITUT FÜR DIAGNOSTIKFORSCHUNG GmbH AN DER FREIEN UNIVERSITÄT BERLIN Means for diagnosis of angiogenic diseases
JPH0772571A (en) * 1993-09-02 1995-03-17 Fuji Photo Film Co Ltd Novel coordination compound, silver halide photographic sensitive material containing same compound, photographic processing composition and processing method
EP0726077A2 (en) * 1995-01-09 1996-08-14 NIHON MEDI-PHYSICS Co., Ltd. Radioactive copper complex of dithiosemicarbazone derivative or diamine diol schiff base derivative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB793802A (en) 1954-06-10 1958-04-23 Tno Improvements in or relating to the preparation of aromatic isothiocyanates
FR1528968A (en) 1966-05-14 1968-06-14 Hoechst Ag Process for the preparation of bis-thiosemicarbazones
GB1143940A (en) 1966-05-24 1969-02-26 Wellcome Found Dithiosemicarbazones having coccidiostatic activity

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3674873A (en) * 1964-07-23 1972-07-04 Burroughs Wellcome Co Method of treating or preventing coccidiosis
US3483207A (en) * 1966-02-19 1969-12-09 Hoechst Ag Unsymmetrical bis-thiosemicarbazones
US3792052A (en) * 1969-11-18 1974-02-12 May & Baker Ltd Hydrazinecarbodithioate derivatives and metal chelates thereof
GB1448295A (en) * 1974-05-01 1976-09-02 Farmaceutici Italia Thiosemicarbazones
EP0306168A1 (en) * 1987-08-12 1989-03-08 Immunomedics, Inc. Preparation of radiolabeled conjugates
WO1992007860A2 (en) * 1990-10-29 1992-05-14 Mallinckrodt Medical, Inc. TECHNETIUM-99m COMPLEXES FOR USE AS RADIOPHARMACEUTICALS
EP0606683A2 (en) * 1993-01-13 1994-07-20 INSTITUT FÜR DIAGNOSTIKFORSCHUNG GmbH AN DER FREIEN UNIVERSITÄT BERLIN Means for diagnosis of angiogenic diseases
JPH0772571A (en) * 1993-09-02 1995-03-17 Fuji Photo Film Co Ltd Novel coordination compound, silver halide photographic sensitive material containing same compound, photographic processing composition and processing method
EP0726077A2 (en) * 1995-01-09 1996-08-14 NIHON MEDI-PHYSICS Co., Ltd. Radioactive copper complex of dithiosemicarbazone derivative or diamine diol schiff base derivative

Non-Patent Citations (14)

* Cited by examiner, † Cited by third party
Title
BAKER E ET AL: "EVALUATION OF THE IRON CHELATION POTENTIAL OF HYDRAZONES OF PYRIDOXAL, SALICYLALDEHYDE AND 2-HYDROXY-1-NAPHTHYLALDEHYDE USING THE HEPATOCYTE IN CULTURE", HEPATOLOGY, WILLIAMS AND WILKINS, BALTIMORE, MD, US, vol. 15, no. 3, 1992, pages 492 - 501, XP000654330, ISSN: 0270-9139 *
DATABASE BEILSTEIN BEILSTEIN CROSSFIRE INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, DE; 1973, XP002405160 *
DATABASE BEILSTEIN BEILSTEIN CROSSFIRE INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, DE; 1978, XP002405162 *
DATABASE BEILSTEIN BEILSTEIN CROSSFIRE INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, DE; 2000, XP002405161 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1985, DILANYAN, E. R. ET AL: "Comparative polarographic study of copper chelates of substituted bis(thiosemicarbazones)", XP002405163, retrieved from STN Database accession no. 1985:461310 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1990, OVSEPYAN, T. R. ET AL: "Novel bisthiosemicarbazones of glyoxal, benzil, and their chelates with copper(2+): synthesis and biological activity", XP002405164, retrieved from STN Database accession no. 1990:611 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2001, DILANYAN, E. R. ET AL: "Synthesis and antitumor activity of new methylglyoxal and glucosone bisthiosemicarbazones and their copper complexes", XP002405165, retrieved from STN Database accession no. 2001:231086 *
DEARLING J L J ET AL: "Redox-active metal complexes for imaging hypoxic tissues: Structure-activity relationships in copper(II) bis(thiosemicarbazone) complexes", CHEMICAL COMMUNICATIONS 21 NOV 1998 UNITED KINGDOM, vol. 4, no. 22, 21 November 1998 (1998-11-21), pages 2531 - 2532, XP002405152, ISSN: 1359-7345 *
FUJIBAYASHI Y ET AL: "NEW NONNITROIMIDAZOLE HYPOXIA IMAGING AGENTS, CU-62-DITHIOSEMICARBAZONE COMPLEXES WITH LOW REDOX POTENTIAL", JOURNAL OF NUCLEAR MEDICINE, SOCIETY OF NUCLEAR MEDICINE, RESTON, VA, US, vol. 36, no. 5, May 1995 (1995-05-01), pages 49P, XP002027512, ISSN: 0161-5505 *
KHIMIKO-FARMATSEVTICHESKII ZHURNAL , 23(6), 678-82 CODEN: KHFZAN; ISSN: 0023-1134, 1989 *
MATHIS C A ET AL: "A Lipophilic Thioflavin-T Derivative for Positron Emission Tomography (PET) Imaging of Amyloid in Brain", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 12, 2002, pages 295 - 298, XP002285913, ISSN: 0960-894X *
PHARMACEUTICAL CHEMISTRY JOURNAL (TRANSLATION OF KHIMIKO-FARMATSEVTICHESKII ZHURNAL) , 34(8), 408-410 CODEN: PCJOAU; ISSN: 0091-150X, 2000 *
XUE Z-M ET AL: "One- and two-photon excited dual fluorescence properties of zinc(II) and cadmiun(II) complexes containnig 4-dipropylamino-benzaldehyde thiosemicarbazone", JOURNAL OF THE CHEMICAL SOCIETY, DALTON TRANSACTIONS, CHEMICAL SOCIETY. LETCHWORTH, GB, 2003, pages 1373 - 1378, XP002405153, ISSN: 1472-7773 *
ZHURNAL OBSHCHEI KHIMII , 55(2), 420-2 CODEN: ZOKHA4; ISSN: 0044-460X, 1985 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104212841A (en) * 2014-08-22 2014-12-17 浙江工业大学 Method for preparing (R)-3,5-bis(trifluoromethyl)phenethyl alcohol in ionic liquid-containing cosolvent medium

Also Published As

Publication number Publication date
GB0513812D0 (en) 2005-08-10
US20110098353A1 (en) 2011-04-28
WO2007003944A2 (en) 2007-01-11
US8299285B2 (en) 2012-10-30

Similar Documents

Publication Publication Date Title
WO2007003944A3 (en) Compounds for imaging and therapy
EP1889842A4 (en) Heterocyclic compound
WO2007033780A3 (en) Thiazoles used as fungicides
WO2007010273A3 (en) Use of thiazole derivatives and analogues in the treatment of cancer
EP2295053B8 (en) Novel 2H-chromen-2-one-3-carboxamides for medical uses
TW200800969A (en) Compounds
WO2007087395A3 (en) UNSATURATED mTOR INHIBITORS
WO2008120759A1 (en) Urea compound and use thereof
AU2001210604A1 (en) Genotyping kit for diagnosis of human papillomavirus infection
WO2008123469A1 (en) Six-membered amide compound and use thereof
WO2006041631A3 (en) Novel cyclosporin alkynes and their utility as pharmaceutical agents
WO2007017695A3 (en) Dihydroxyanthraquinones and their use
WO2005021544A3 (en) N3-substituted imidazopyridine-derivatives as c-kit inhibitors
AU2003268094A1 (en) Medical slings
WO2007099548A3 (en) Novel 11 beta - hydroxyandrosta-4-ene-3-ones
WO2008021804A3 (en) Therapeutic amides and related compounds
WO2008021975A3 (en) Therapeutic lactams
WO2005080403A3 (en) Chemical process
WO2007025089A3 (en) Triazole compounds and methods of making and using the same
WO2007018941A3 (en) Pyrimidyl-thiophene derivatives
EP1671948A4 (en) Cinnamoyl compound and use of the same
WO2003015780A3 (en) Isoxazolopyridinones and use thereof in the treatment of parkinson's disease
WO2006080043A3 (en) Organic compounds useful for the treatment of alzheimer's disease, their use and method of preparation
EP1671961A4 (en) Cinnamoyl compound and use of the same
AU2003282878A1 (en) Diagnosis of invasive mold infection

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Country of ref document: DE

WWE Wipo information: entry into national phase

Ref document number: 11988230

Country of ref document: US

122 Ep: pct application non-entry in european phase

Ref document number: 06755711

Country of ref document: EP

Kind code of ref document: A2