WO2007149827A3 - Method for modulating the pharmacokinetics and metabolism of a therapeutic agent - Google Patents

Method for modulating the pharmacokinetics and metabolism of a therapeutic agent Download PDF

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Publication number
WO2007149827A3
WO2007149827A3 PCT/US2007/071510 US2007071510W WO2007149827A3 WO 2007149827 A3 WO2007149827 A3 WO 2007149827A3 US 2007071510 W US2007071510 W US 2007071510W WO 2007149827 A3 WO2007149827 A3 WO 2007149827A3
Authority
WO
WIPO (PCT)
Prior art keywords
therapeutic agent
pharmacokinetics
metabolism
modulating
agent
Prior art date
Application number
PCT/US2007/071510
Other languages
French (fr)
Other versions
WO2007149827A2 (en
Inventor
Gary M Eichenbaum
Original Assignee
Janssen Pharmaceutica Nv
Gary M Eichenbaum
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv, Gary M Eichenbaum filed Critical Janssen Pharmaceutica Nv
Priority to EP07812192A priority Critical patent/EP2037954A4/en
Publication of WO2007149827A2 publication Critical patent/WO2007149827A2/en
Publication of WO2007149827A3 publication Critical patent/WO2007149827A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01031—Beta-glucuronidase (3.2.1.31)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

This invention is a method for enhancing the activity of a therapeutic agent comprising the administration of the agent in combination with an enzyme, whereby a metabolic pathway of the therapeutic agent is counteracted and the agent's pharmacokinetics and metabolism are modulated.
PCT/US2007/071510 2006-06-20 2007-06-19 Method for modulating the pharmacokinetics and metabolism of a therapeutic agent WO2007149827A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07812192A EP2037954A4 (en) 2006-06-20 2007-06-19 Method for modulating the pharmacokinetics and metabolism of a therapeutic agent

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81522306P 2006-06-20 2006-06-20
US60/815,223 2006-06-20

Publications (2)

Publication Number Publication Date
WO2007149827A2 WO2007149827A2 (en) 2007-12-27
WO2007149827A3 true WO2007149827A3 (en) 2009-04-23

Family

ID=38834295

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/071510 WO2007149827A2 (en) 2006-06-20 2007-06-19 Method for modulating the pharmacokinetics and metabolism of a therapeutic agent

Country Status (2)

Country Link
EP (1) EP2037954A4 (en)
WO (1) WO2007149827A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102097026B (en) * 2009-12-14 2013-04-10 中国科学院上海药物研究所 Device and method for simulating pharmacokinetics characteristics in vitro

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877158A (en) * 1993-09-22 1999-03-02 Behringwerke Aktiengesellschaft Pro-prodrugs, their production and use
US5955100A (en) * 1992-10-27 1999-09-21 Behringwerke Aktiengesellschaft Prodrugs their preparation and use as pharmaceuticals
US5985281A (en) * 1994-12-23 1999-11-16 Zeneca Limited Chemical compounds
US20040082639A1 (en) * 2002-05-15 2004-04-29 Ho Chih Yung N-substituted tricyclic 3-aminopyrazoles as inhibitors for the treatment of cell proliferative disorders
US20050025709A1 (en) * 2003-06-13 2005-02-03 Immunomedics, Inc. D-amino acid peptides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5279824A (en) * 1988-04-14 1994-01-18 Merck Patent Gmbh Pharmaceutical formulation containing heparin and endo-beta-glucuronidase, useful for the treatment of thrombosis
US20040071685A1 (en) * 2002-10-09 2004-04-15 Devin Houston Compositions and methods for increasing the bioavailability of plant polyphenols
US7871607B2 (en) * 2003-03-05 2011-01-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
WO2006042056A2 (en) * 2004-10-08 2006-04-20 The Ohio State University Methods and compositions for enzyme-specific activation of carbohydrate-conjugated prodrugs

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5955100A (en) * 1992-10-27 1999-09-21 Behringwerke Aktiengesellschaft Prodrugs their preparation and use as pharmaceuticals
US5877158A (en) * 1993-09-22 1999-03-02 Behringwerke Aktiengesellschaft Pro-prodrugs, their production and use
US5985281A (en) * 1994-12-23 1999-11-16 Zeneca Limited Chemical compounds
US20040082639A1 (en) * 2002-05-15 2004-04-29 Ho Chih Yung N-substituted tricyclic 3-aminopyrazoles as inhibitors for the treatment of cell proliferative disorders
US20050025709A1 (en) * 2003-06-13 2005-02-03 Immunomedics, Inc. D-amino acid peptides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2037954A4 *

Also Published As

Publication number Publication date
EP2037954A4 (en) 2011-09-14
WO2007149827A2 (en) 2007-12-27
EP2037954A2 (en) 2009-03-25

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