EP2037954A4 - Method for modulating the pharmacokinetics and metabolism of a therapeutic agent - Google Patents
Method for modulating the pharmacokinetics and metabolism of a therapeutic agentInfo
- Publication number
- EP2037954A4 EP2037954A4 EP07812192A EP07812192A EP2037954A4 EP 2037954 A4 EP2037954 A4 EP 2037954A4 EP 07812192 A EP07812192 A EP 07812192A EP 07812192 A EP07812192 A EP 07812192A EP 2037954 A4 EP2037954 A4 EP 2037954A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- pharmacokinetics
- metabolism
- modulating
- therapeutic agent
- therapeutic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01031—Beta-glucuronidase (3.2.1.31)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81522306P | 2006-06-20 | 2006-06-20 | |
PCT/US2007/071510 WO2007149827A2 (en) | 2006-06-20 | 2007-06-19 | Method for modulating the pharmacokinetics and metabolism of a therapeutic agent |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2037954A2 EP2037954A2 (en) | 2009-03-25 |
EP2037954A4 true EP2037954A4 (en) | 2011-09-14 |
Family
ID=38834295
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP07812192A Withdrawn EP2037954A4 (en) | 2006-06-20 | 2007-06-19 | Method for modulating the pharmacokinetics and metabolism of a therapeutic agent |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP2037954A4 (en) |
WO (1) | WO2007149827A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102097026B (en) * | 2009-12-14 | 2013-04-10 | 中国科学院上海药物研究所 | Device and method for simulating pharmacokinetics characteristics in vitro |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5279824A (en) * | 1988-04-14 | 1994-01-18 | Merck Patent Gmbh | Pharmaceutical formulation containing heparin and endo-beta-glucuronidase, useful for the treatment of thrombosis |
US20040071685A1 (en) * | 2002-10-09 | 2004-04-15 | Devin Houston | Compositions and methods for increasing the bioavailability of plant polyphenols |
US20050260186A1 (en) * | 2003-03-05 | 2005-11-24 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases |
WO2006042056A2 (en) * | 2004-10-08 | 2006-04-20 | The Ohio State University | Methods and compositions for enzyme-specific activation of carbohydrate-conjugated prodrugs |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4236237A1 (en) * | 1992-10-27 | 1994-04-28 | Behringwerke Ag | Prodrugs, their preparation and use as medicines |
PT648503E (en) * | 1993-09-22 | 2000-11-30 | Hoechst Ag | PRO-PROFARMACOS, ITS PRODUCTION AND UTILIZATION |
KR100270650B1 (en) * | 1994-12-23 | 2000-11-01 | 돈 리사 로얄 | Antibody directed enzyme prodrug therapy using mutated form of host enzymes |
WO2003097609A1 (en) * | 2002-05-15 | 2003-11-27 | Janssen Pharmaceutica N.V. | N-substituted tricyclic 3-aminopyrazoles as pdfg receptor inhibitors |
WO2005021494A2 (en) * | 2003-06-13 | 2005-03-10 | Immunomedics, Inc. | D-amino acid peptides |
-
2007
- 2007-06-19 WO PCT/US2007/071510 patent/WO2007149827A2/en active Application Filing
- 2007-06-19 EP EP07812192A patent/EP2037954A4/en not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5279824A (en) * | 1988-04-14 | 1994-01-18 | Merck Patent Gmbh | Pharmaceutical formulation containing heparin and endo-beta-glucuronidase, useful for the treatment of thrombosis |
US20040071685A1 (en) * | 2002-10-09 | 2004-04-15 | Devin Houston | Compositions and methods for increasing the bioavailability of plant polyphenols |
US20050260186A1 (en) * | 2003-03-05 | 2005-11-24 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases |
WO2006042056A2 (en) * | 2004-10-08 | 2006-04-20 | The Ohio State University | Methods and compositions for enzyme-specific activation of carbohydrate-conjugated prodrugs |
Non-Patent Citations (2)
Title |
---|
HOUBA P H ET AL: "Pronounced antitumor efficacy of doxorubicin when given as the prodrug DOX-GA3 in combination with a monoclonal antibody beta-glucuronidase conjugate.", INTERNATIONAL JOURNAL OF CANCER. JOURNAL INTERNATIONAL DU CANCER 15 FEB 2001 LNKD- PUBMED:11251980, vol. 91, no. 4, 15 February 2001 (2001-02-15), pages 550 - 554, XP002655272, ISSN: 0020-7136 * |
YAN Z ET AL: "N-glucuronidation of the platelet-derived growth factor receptor tyrosine kinase inhibitor 6,7-(dimethoxy-2,4-dihydroindeno[1,2-c]pyra zol-3-yl)-(3-fluoro-phenyl)-amine by human UDP-glucuronosyltransferases", DRUG METABOLISM AND DISPOSITION, vol. 34, no. 5, May 2006 (2006-05-01), pages 748 - 755, XP002655273, ISSN: 0090-9556 * |
Also Published As
Publication number | Publication date |
---|---|
WO2007149827A3 (en) | 2009-04-23 |
EP2037954A2 (en) | 2009-03-25 |
WO2007149827A2 (en) | 2007-12-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20081219 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL BA HR MK RS |
|
R17D | Deferred search report published (corrected) |
Effective date: 20090423 |
|
DAX | Request for extension of the european patent (deleted) | ||
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 38/46 20060101ALI20110804BHEP Ipc: A61K 38/44 20060101ALI20110804BHEP Ipc: A61K 38/43 20060101AFI20110804BHEP |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20110816 |
|
17Q | First examination report despatched |
Effective date: 20130301 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20130712 |