WO2007144781A3 - Diagnostic methods and kits utilizing antibodies for metalloproteases - Google Patents

Diagnostic methods and kits utilizing antibodies for metalloproteases Download PDF

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Publication number
WO2007144781A3
WO2007144781A3 PCT/IB2007/002916 IB2007002916W WO2007144781A3 WO 2007144781 A3 WO2007144781 A3 WO 2007144781A3 IB 2007002916 W IB2007002916 W IB 2007002916W WO 2007144781 A3 WO2007144781 A3 WO 2007144781A3
Authority
WO
WIPO (PCT)
Prior art keywords
metalloproteases
diagnostic methods
antibodies
utilizing antibodies
kits
Prior art date
Application number
PCT/IB2007/002916
Other languages
French (fr)
Other versions
WO2007144781A2 (en
Inventor
James Watson Goding
Alexander Lopata
Original Assignee
Diagnotech Pty Ltd
James Watson Goding
Alexander Lopata
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2006902101A external-priority patent/AU2006902101A0/en
Application filed by Diagnotech Pty Ltd, James Watson Goding, Alexander Lopata filed Critical Diagnotech Pty Ltd
Publication of WO2007144781A2 publication Critical patent/WO2007144781A2/en
Publication of WO2007144781A3 publication Critical patent/WO2007144781A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C12N9/1088—Glutathione transferase (2.5.1.18)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57442—Specifically defined cancers of the uterus and endometrial
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486—Metalloendopeptidases (3.4.24)
    • G01N2333/96491—Metalloendopeptidases (3.4.24) with definite EC number
    • G01N2333/96494—Matrix metalloproteases, e. g. 3.4.24.7

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Disclosed are monoclonal antibodies and detection methods using these antibodies, diagnostic kits and detection kits comprising the antibodies, related fusion proteins, and immunogenic compositions comprising the fusion proteins. In particular, monoclonal antibodies directed to matrix metalloprotease-2 and/or matrix metalloprotease-9 (MMP-2 and MMP-9) are disclosed with regard to their use in the detection of cancers and other disorders, such as endometrial cancer or renal cancer.
PCT/IB2007/002916 2006-04-21 2007-04-23 Diagnostic methods and kits utilizing antibodies for metalloproteases WO2007144781A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US79363806P 2006-04-21 2006-04-21
AU2006902101A AU2006902101A0 (en) 2006-04-21 Diagnostic methods and kits utilizing antibodies for metalloproteases
AU2006902101 2006-04-21
US60/793,638 2006-04-21

Publications (2)

Publication Number Publication Date
WO2007144781A2 WO2007144781A2 (en) 2007-12-21
WO2007144781A3 true WO2007144781A3 (en) 2008-06-05

Family

ID=38832179

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/002916 WO2007144781A2 (en) 2006-04-21 2007-04-23 Diagnostic methods and kits utilizing antibodies for metalloproteases

Country Status (1)

Country Link
WO (1) WO2007144781A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011269775B2 (en) 2010-06-23 2015-01-15 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
KR101881724B1 (en) 2010-08-27 2018-07-24 길리아드 바이오로직스, 인크. Antibodies to matrix metalloproteinase 9
PT2748605T (en) * 2011-08-26 2019-05-03 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
MX2014010447A (en) 2012-02-29 2015-06-23 Gilead Biologics Inc Antibodies to matrix metalloproteinase 9.
EP3577458A4 (en) 2017-02-06 2021-04-07 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP3775193A1 (en) * 2018-03-29 2021-02-17 The University of Liverpool Peptides and conjugates

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BANYAI L. ET AL.: "The gelatin-binding site of human 72 kDa type IV collagenase (gelatinase A)", BIOCHEMICAL, vol. 298, 1994, pages 403 - 407 *
COLLIER I.E. ET AL.: "Alanine scanning mutagenesis and functional analysis of the fibronectin-like collagen-binding domain from human 92 kDa Type IV collagenase", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 267, no. 10, 1992, pages 6776 - 6781 *
KAPUST R.B. AND WAUGH D.S.: "Escherichia coli maltose-binding protein is uncommonly effective at promoting the solubility of polypeptides to which it is fused", PROTEIN SCIENCE, vol. 8, 1999, pages 1668 - 1674 *
NYGREN P.-A. ET AL.: "Engineering proteins to facilitate bioprocessing", TRENDS IN BIOTECHNOLOGY, vol. 12, no. 5, 1994, pages 184 - 188, XP023594822, DOI: doi:10.1016/0167-7799(94)90080-9 *
O'FARRELL T.J. AND POURMOTABBED T.: "Identification of structural elements important for matrix metalloproteinase Type collagenolytic activity as revealed by chimeric enzymes", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 36, 2000, pages 27964 - 27972 *
PRYOR K.D. AND LEITING B.: "High-level expression of soluble protein in Escherichia coli using a His6-tag and maltose-binding-protein double-affinity fusion system", PROTEIN EXPRESSION AND PURIFICATION, vol. 10, no. 3, 1997, pages 309 - 319 *

Also Published As

Publication number Publication date
WO2007144781A2 (en) 2007-12-21

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