WO2007141811A3 - processus d'élaboration d'un substrat semi-conducteur pour analyse biologique - Google Patents

processus d'élaboration d'un substrat semi-conducteur pour analyse biologique Download PDF

Info

Publication number
WO2007141811A3
WO2007141811A3 PCT/IT2006/000420 IT2006000420W WO2007141811A3 WO 2007141811 A3 WO2007141811 A3 WO 2007141811A3 IT 2006000420 W IT2006000420 W IT 2006000420W WO 2007141811 A3 WO2007141811 A3 WO 2007141811A3
Authority
WO
WIPO (PCT)
Prior art keywords
silicon dioxide
semiconductor substrate
biological analysis
silane
treating
Prior art date
Application number
PCT/IT2006/000420
Other languages
English (en)
Other versions
WO2007141811A2 (fr
Inventor
Andrea Frosini
Alessandra Fischetti
Original Assignee
St Microelectronics Srl
Andrea Frosini
Alessandra Fischetti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by St Microelectronics Srl, Andrea Frosini, Alessandra Fischetti filed Critical St Microelectronics Srl
Priority to PCT/IT2006/000420 priority Critical patent/WO2007141811A2/fr
Publication of WO2007141811A2 publication Critical patent/WO2007141811A2/fr
Publication of WO2007141811A3 publication Critical patent/WO2007141811A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

L'invention concerne un processus d'élaboration d'un substrat semi-conducteur pour analyse biologique dans un dispositif intégré, l'analyse biologique comprenant les phases consistant à amplifier l'ADN et à détecter l'ADN amplifié dans la même chambre, qui comprend les phases consistant à a) former une surface de dioxyde de silicium sur ledit substrat semi-conducteur ; b) traiter ladite surface de dioxyde de silicium avec un silane ; c) former une surface silanisée ; d) greffer des sondes d'acide nucléique ; e) traiter ladite surface silanée avec un agent de désactivation et f) former un substrat désactivé de manière séquentielle. De plus le processus peut comprendre la phase consistant à nettoyer le substrat de dioxyde de silicium avant la phase de traitement de ladite surface de dioxyde de silicium avec un silane et la phase consistant à mettre en réaction le groupe terminal du silane avec un agent réticulant ou en variante la phase consistant à mettre en réaction les sondes d'acide nucléique dérivées avec un agent réticulant, avant la phase de greffe.
PCT/IT2006/000420 2006-06-06 2006-06-06 processus d'élaboration d'un substrat semi-conducteur pour analyse biologique WO2007141811A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/IT2006/000420 WO2007141811A2 (fr) 2006-06-06 2006-06-06 processus d'élaboration d'un substrat semi-conducteur pour analyse biologique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IT2006/000420 WO2007141811A2 (fr) 2006-06-06 2006-06-06 processus d'élaboration d'un substrat semi-conducteur pour analyse biologique

Publications (2)

Publication Number Publication Date
WO2007141811A2 WO2007141811A2 (fr) 2007-12-13
WO2007141811A3 true WO2007141811A3 (fr) 2008-02-28

Family

ID=38801909

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT2006/000420 WO2007141811A2 (fr) 2006-06-06 2006-06-06 processus d'élaboration d'un substrat semi-conducteur pour analyse biologique

Country Status (1)

Country Link
WO (1) WO2007141811A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009151407A2 (fr) 2008-06-14 2009-12-17 Veredus Laboratories Pte Ltd Séquences de la grippe

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005910A1 (fr) * 1988-11-14 1990-05-31 I Stat Corp Biocapteurs entierement microfabriques et procede de production et utilisation de ces capteurs
US5688642A (en) * 1994-12-01 1997-11-18 The United States Of America As Represented By The Secretary Of The Navy Selective attachment of nucleic acid molecules to patterned self-assembled surfaces
US5919523A (en) * 1995-04-27 1999-07-06 Affymetrix, Inc. Derivatization of solid supports and methods for oligomer synthesis
WO2001012846A1 (fr) * 1999-08-16 2001-02-22 Pamgene B.V. Preparation de supports d'oxydes metalliques charges de biomolecules
US6284465B1 (en) * 1999-04-15 2001-09-04 Agilent Technologies, Inc. Apparatus, systems and method for locating nucleic acids bound to surfaces
US6387626B1 (en) * 1997-06-06 2002-05-14 Orchid Biosciences, Inc. Covalent attachment of unmodified nucleic acids to silanized solid phase surfaces
WO2003040700A1 (fr) * 2001-11-08 2003-05-15 Ciphergen Biosystems, Inc. Puce a surface hydrophobe
WO2004001506A2 (fr) * 2002-06-20 2003-12-31 Affymetrix, Inc. Revetements antireflet pour synthese photolithographique a haute resolution d'arrangements adn
EP1413352A1 (fr) * 2002-10-21 2004-04-28 Agilent Technologies Inc. (a Delaware Corporation) Liaison à un assemblage de matrices chimiques comportant couches métalliques
WO2005005039A1 (fr) * 2003-06-30 2005-01-20 Agilent Technologies, Inc. Procede de production de microreseaux de ligands
WO2005029042A2 (fr) * 2003-09-23 2005-03-31 Massachusetts Institute Of Technology Fabrication et emballage de detecteurs de microcanaux suspendus

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005910A1 (fr) * 1988-11-14 1990-05-31 I Stat Corp Biocapteurs entierement microfabriques et procede de production et utilisation de ces capteurs
US5688642A (en) * 1994-12-01 1997-11-18 The United States Of America As Represented By The Secretary Of The Navy Selective attachment of nucleic acid molecules to patterned self-assembled surfaces
US5919523A (en) * 1995-04-27 1999-07-06 Affymetrix, Inc. Derivatization of solid supports and methods for oligomer synthesis
US6387626B1 (en) * 1997-06-06 2002-05-14 Orchid Biosciences, Inc. Covalent attachment of unmodified nucleic acids to silanized solid phase surfaces
US6284465B1 (en) * 1999-04-15 2001-09-04 Agilent Technologies, Inc. Apparatus, systems and method for locating nucleic acids bound to surfaces
WO2001012846A1 (fr) * 1999-08-16 2001-02-22 Pamgene B.V. Preparation de supports d'oxydes metalliques charges de biomolecules
WO2003040700A1 (fr) * 2001-11-08 2003-05-15 Ciphergen Biosystems, Inc. Puce a surface hydrophobe
WO2004001506A2 (fr) * 2002-06-20 2003-12-31 Affymetrix, Inc. Revetements antireflet pour synthese photolithographique a haute resolution d'arrangements adn
EP1413352A1 (fr) * 2002-10-21 2004-04-28 Agilent Technologies Inc. (a Delaware Corporation) Liaison à un assemblage de matrices chimiques comportant couches métalliques
WO2005005039A1 (fr) * 2003-06-30 2005-01-20 Agilent Technologies, Inc. Procede de production de microreseaux de ligands
WO2005029042A2 (fr) * 2003-09-23 2005-03-31 Massachusetts Institute Of Technology Fabrication et emballage de detecteurs de microcanaux suspendus

Also Published As

Publication number Publication date
WO2007141811A2 (fr) 2007-12-13

Similar Documents

Publication Publication Date Title
WO2006117676A3 (fr) Procede de detection et de caracterisation de micro-organismes sur un filtre
WO2005019836A3 (fr) Appareil permettant le traitement d'un echantillon de fluide
WO2006028601A3 (fr) Technique permettant de distinguer un staphylocoque dore resistant a la methicilline d'un staphylocoque dore sensible a la methicilline dans une culture mixte
WO2004067162A3 (fr) Appareil pour le traitement microfluidique et la lecture de matrices de biopuces
WO2007075928A3 (fr) Dispositif de dosage a patch integre avec moyens de detection visuelle
WO2007086935A8 (fr) Méthodes d'amplification pour le séquençage d'acides nucléiques
JP2020534509A (ja) ヒドロゲルコーティングを有するフローセル
SG149007A1 (en) Expression profiling using microarrays
WO2008132656A3 (fr) Puce de biocapteur et son procédé de fabrication
WO2005003375A3 (fr) Procede d'amplification et de sequençage d'acides nucleiques
WO2007084192A3 (fr) Dosage colorimétrique par amplification de codes-barres biochimiques pour détecter un analyte
EP2305809A3 (fr) Procédés d'isolation d'acide nucléique et kits utilisant un dispositif microfluidique et étape de concentration
AU2003206736A1 (en) Reaction vessel for carrying out array processes
WO2006063065A3 (fr) Detection d'acides nucleiques de types multiples de papillomavirus humains
WO2007066831A3 (fr) Procede de detection du papillomavirus humain par le procede d'amplification d'acide nucleique et support immobilise de chaine d'acide nucleique
WO2006086737A3 (fr) Essai mir-155
WO2007140279A3 (fr) Compositions, méthodes et kits permettant de déterminer la présence d'organismes complexes de mycobacterium tuberculosis dans un échantillon d'essai
ATE269161T1 (de) Kontaktierungsvorrichtung
WO2004104211A3 (fr) Procede de detection de cyanobacteries toxiques et non toxiques
WO2008054432A3 (fr) Micropuce oligonucléotidique destinée à l'identification d'agents pathogènes
EP1741793A4 (fr) Procede d'hybridisation
AU2003201910A1 (en) Nucleic acid detection method and system thereof
WO2005047855A3 (fr) Procédé de préparation d'acides nucléiques pour la détection
WO2007141811A3 (fr) processus d'élaboration d'un substrat semi-conducteur pour analyse biologique
JP5429962B2 (ja) 核酸検出方法及び核酸検出キット

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 06766311

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: RU

122 Ep: pct application non-entry in european phase

Ref document number: 06766311

Country of ref document: EP

Kind code of ref document: A2