WO2007137196A3 - Tubulin binding anti cancer compounds and prodrugs thereof - Google Patents

Tubulin binding anti cancer compounds and prodrugs thereof Download PDF

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Publication number
WO2007137196A3
WO2007137196A3 PCT/US2007/069297 US2007069297W WO2007137196A3 WO 2007137196 A3 WO2007137196 A3 WO 2007137196A3 US 2007069297 W US2007069297 W US 2007069297W WO 2007137196 A3 WO2007137196 A3 WO 2007137196A3
Authority
WO
WIPO (PCT)
Prior art keywords
prodrugs
tubulin binding
anti cancer
cancer compounds
binding anti
Prior art date
Application number
PCT/US2007/069297
Other languages
French (fr)
Other versions
WO2007137196A2 (en
Inventor
Mark Matteucci
Jian-Xin Duan
Xiaohong Cai
Jiayao Li
Jason Lewis
Original Assignee
Threshold Pharmaceuticals Inc
Mark Matteucci
Jian-Xin Duan
Xiaohong Cai
Jiayao Li
Jason Lewis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Threshold Pharmaceuticals Inc, Mark Matteucci, Jian-Xin Duan, Xiaohong Cai, Jiayao Li, Jason Lewis filed Critical Threshold Pharmaceuticals Inc
Publication of WO2007137196A2 publication Critical patent/WO2007137196A2/en
Publication of WO2007137196A3 publication Critical patent/WO2007137196A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole

Abstract

Novel tublin binding compuunds and hypoxia activated prodrugs of novel and known tubulin binding compounds are useful for treating cancer and other hyperproliferative diseases.
PCT/US2007/069297 2006-05-19 2007-05-18 Tubulin binding anti cancer compounds and prodrugs thereof WO2007137196A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80226706P 2006-05-19 2006-05-19
US60/802,267 2006-05-19

Publications (2)

Publication Number Publication Date
WO2007137196A2 WO2007137196A2 (en) 2007-11-29
WO2007137196A3 true WO2007137196A3 (en) 2008-01-24

Family

ID=38724050

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/069297 WO2007137196A2 (en) 2006-05-19 2007-05-18 Tubulin binding anti cancer compounds and prodrugs thereof

Country Status (1)

Country Link
WO (1) WO2007137196A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE112010005848B4 (en) * 2010-09-06 2016-03-10 Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences amide compounds

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5972976A (en) * 1994-04-06 1999-10-26 Nippon Shinyaku Company, Limited Aminostilbazole derivative and medicine
US20050222090A1 (en) * 2003-12-30 2005-10-06 Gilead Sciences, Inc. Anti-proliferative compounds, compositions, and methods of use thereof
US20060014708A1 (en) * 2004-07-15 2006-01-19 Bartkovitz David J 2,6-Diaminopyridine derivatives
US7001926B2 (en) * 2000-03-10 2006-02-21 Oxigene, Inc. Tubulin binding agents and corresponding prodrug constructs

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5972976A (en) * 1994-04-06 1999-10-26 Nippon Shinyaku Company, Limited Aminostilbazole derivative and medicine
US7001926B2 (en) * 2000-03-10 2006-02-21 Oxigene, Inc. Tubulin binding agents and corresponding prodrug constructs
US20050222090A1 (en) * 2003-12-30 2005-10-06 Gilead Sciences, Inc. Anti-proliferative compounds, compositions, and methods of use thereof
US20060014708A1 (en) * 2004-07-15 2006-01-19 Bartkovitz David J 2,6-Diaminopyridine derivatives

Also Published As

Publication number Publication date
WO2007137196A2 (en) 2007-11-29

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