WO2007136302A8 - Active substances, pharmaceutical composition and a method for the production and use thereof - Google Patents

Active substances, pharmaceutical composition and a method for the production and use thereof

Info

Publication number
WO2007136302A8
WO2007136302A8 PCT/RU2007/000246 RU2007000246W WO2007136302A8 WO 2007136302 A8 WO2007136302 A8 WO 2007136302A8 RU 2007000246 W RU2007000246 W RU 2007000246W WO 2007136302 A8 WO2007136302 A8 WO 2007136302A8
Authority
WO
WIPO (PCT)
Prior art keywords
optionally substituted
hydrogen
substituent selected
atom
alkyl
Prior art date
Application number
PCT/RU2007/000246
Other languages
French (fr)
Russian (ru)
Other versions
WO2007136302A2 (en
WO2007136302A3 (en
Inventor
Alexander Vasiliev Ivashchenko
Andrey Alexandrovi Ivashchenko
Irina Anatolievna Leneva
Nikolay Filippovich Savchuk
Original Assignee
Alla Chem Llc
Zakrytoe Aktzionernoye Obsches
Alexander Vasiliev Ivashchenko
Andrey Alexandrovi Ivashchenko
Irina Anatolievna Leneva
Nikolay Filippovich Savchuk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from RU2006117557/04A external-priority patent/RU2323210C9/en
Priority claimed from RU2006117558/04A external-priority patent/RU2323221C9/en
Priority claimed from RU2007105735/04A external-priority patent/RU2338531C1/en
Priority claimed from RU2007106408/04A external-priority patent/RU2332421C1/en
Application filed by Alla Chem Llc, Zakrytoe Aktzionernoye Obsches, Alexander Vasiliev Ivashchenko, Andrey Alexandrovi Ivashchenko, Irina Anatolievna Leneva, Nikolay Filippovich Savchuk filed Critical Alla Chem Llc
Publication of WO2007136302A2 publication Critical patent/WO2007136302A2/en
Publication of WO2007136302A3 publication Critical patent/WO2007136302A3/en
Publication of WO2007136302A8 publication Critical patent/WO2007136302A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to novel substituted indoles, to the use thereof in the form of pharmacological composition substances for producing medicinal preparations used for preventing and treating influenza and acute respiratory diseases. The substituted indoles of general formula (1) or the racemates or the optical isomers or the pharmaceutically acceptable salts and/or hydrates thereof, are proposed for the use thereof in the form of active substances of pharmaceutical compositions exhibiting antiviral activity against influenza and acute respiratory diseases, wherein R1, R14 and R24 independently of each other are an aminogroup substituent selected for hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl or optionally substituted heterocyclyl, or R14 and R24 together with a nitrogen atom,with which they are bound, form through R14 and R24 optionally substituted azaheterocyclyl or guanidyl; R 2 is an alkyl substituent selected from hydrogen, an optionally substituted mercaptogroup, optionally substituted aminogroup and optionally substituted hydroxyl; R 3 is lower alkyl, R 5 is an hydrogen atom or R 5 together with an oxygen atom with which it is linked or R24 together with a nitrogen atom with which it is linked close, via R 5 and R24 an oxazine cycle; R 6 is a cyclic system substituent selected for hydrogen, a halogen atom, cyanogroup, optionally substituted aryl or substituted heterocyclyl.
PCT/RU2007/000246 2006-05-23 2007-05-17 Active substances, pharmaceutical composition and a method for the production and use thereof WO2007136302A2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
RU2006117557/04A RU2323210C9 (en) 2006-05-23 2006-05-23 Substituted esters of 1h-indol-3-carboxylic acid, pharmaceutical composition, method for their preparing and using
RU2006117558/04A RU2323221C9 (en) 2006-05-23 2006-05-23 SUBSTITUTED ESTERS OF 1,2,3,7-TETRAHYDROPYRROLO[3,2-f][1,3]BENZOXAZIN-5-CARBOXYLIC ACIDS, PHARMACEUTICAL COMPOSITION, METHOD FOR THEIR PREPARING (VARIANTS) AND USING
RU2006117557 2006-05-23
RU2006117558 2006-05-23
RU2007105735/04A RU2338531C1 (en) 2007-02-16 2007-02-16 Active substances, pharmaceutical composition, method of obtaining and application
RU2007105735 2007-02-16
RU2007106408 2007-02-21
RU2007106408/04A RU2332421C1 (en) 2007-02-21 2007-02-21 Active subctances, pharmaceutical composition, method of their production and application

Publications (3)

Publication Number Publication Date
WO2007136302A2 WO2007136302A2 (en) 2007-11-29
WO2007136302A3 WO2007136302A3 (en) 2008-02-14
WO2007136302A8 true WO2007136302A8 (en) 2008-03-13

Family

ID=38723722

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2007/000246 WO2007136302A2 (en) 2006-05-23 2007-05-17 Active substances, pharmaceutical composition and a method for the production and use thereof

Country Status (1)

Country Link
WO (1) WO2007136302A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2361581C2 (en) * 2007-09-14 2009-07-20 Закрытое Акционерное Общество "Мастерклон" Pharmaceutical composition possessing antidiabetic, hypolipidemic, hypoglycemic and cholesterol lowering action, way of its reception and ways of treatment of specified diseases
CN104193669B (en) * 2014-08-01 2016-12-07 大连理工大学 One class Abiduoer analog or its salt, its preparation method and application

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100361975C (en) * 2003-01-04 2008-01-16 沈阳药科大学 Novel 5-hydroxy-3-carboxylate indoles derivant and method for preparing the same

Also Published As

Publication number Publication date
WO2007136302A2 (en) 2007-11-29
WO2007136302A3 (en) 2008-02-14

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