WO2007133820A3 - Diaryl triazolones as cb1 antagonists - Google Patents

Diaryl triazolones as cb1 antagonists Download PDF

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Publication number
WO2007133820A3
WO2007133820A3 PCT/US2007/060599 US2007060599W WO2007133820A3 WO 2007133820 A3 WO2007133820 A3 WO 2007133820A3 US 2007060599 W US2007060599 W US 2007060599W WO 2007133820 A3 WO2007133820 A3 WO 2007133820A3
Authority
WO
WIPO (PCT)
Prior art keywords
diaryl
triazolones
disorders
compounds
formula
Prior art date
Application number
PCT/US2007/060599
Other languages
French (fr)
Other versions
WO2007133820A2 (en
Inventor
Alan J Hutchison
Jianmin Mao
George D Maynard
Wallace C Pringle
He Zhao
David J Wustrow
Original Assignee
Neurogen Corp
Alan J Hutchison
Jianmin Mao
George D Maynard
Wallace C Pringle
He Zhao
David J Wustrow
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp, Alan J Hutchison, Jianmin Mao, George D Maynard, Wallace C Pringle, He Zhao, David J Wustrow filed Critical Neurogen Corp
Publication of WO2007133820A2 publication Critical patent/WO2007133820A2/en
Publication of WO2007133820A3 publication Critical patent/WO2007133820A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Diaryl triazolones of Formula I are provided, in which the variables are as described herein. Such compounds may be used to modulate CB1 activity in vivo or in vitro, and are particularly useful in the treatment of conditions responsive to CB1 modulation in humans, domesticated companion animals and livestock animals, including appetite disorders, obesity and addictive disorders. Pharmaceutical compositions and methods for using diaryl traizolones of Formula I to treat such disorders are provided, as are methods for using such compounds as ligands for receptor localization studies and various in vitro assays.
PCT/US2007/060599 2006-01-19 2007-01-17 Diaryl triazolones as cb1 antagonists WO2007133820A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76012306P 2006-01-19 2006-01-19
US60/760,123 2006-01-19

Publications (2)

Publication Number Publication Date
WO2007133820A2 WO2007133820A2 (en) 2007-11-22
WO2007133820A3 true WO2007133820A3 (en) 2008-08-28

Family

ID=38694569

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/060599 WO2007133820A2 (en) 2006-01-19 2007-01-17 Diaryl triazolones as cb1 antagonists

Country Status (1)

Country Link
WO (1) WO2007133820A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2025674A1 (en) 2007-08-15 2009-02-18 sanofi-aventis Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs
EP2683699B1 (en) 2011-03-08 2015-06-24 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
US8828995B2 (en) 2011-03-08 2014-09-09 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120052A1 (en) 2011-03-08 2012-09-13 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
WO2012120054A1 (en) 2011-03-08 2012-09-13 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6258957B1 (en) * 1995-06-09 2001-07-10 Bayer Aktiengesellschaft N-aryl-1,2,4-triazolin-5-ones

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6258957B1 (en) * 1995-06-09 2001-07-10 Bayer Aktiengesellschaft N-aryl-1,2,4-triazolin-5-ones

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ENDERS ET AL.: "Preparation and Application of 1,3,4-Triphenyl-4,5-dihydro-1H-1,2,4-triazol-5-ylidene, A Stable Carbene", vol. 8, February 2003 (2003-02-01), pages 1292 - 1295 *

Also Published As

Publication number Publication date
WO2007133820A2 (en) 2007-11-22

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