WO2007133476A3 - Competitive substrate inhibition to increase drug bioavailability - Google Patents

Competitive substrate inhibition to increase drug bioavailability Download PDF

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Publication number
WO2007133476A3
WO2007133476A3 PCT/US2007/010806 US2007010806W WO2007133476A3 WO 2007133476 A3 WO2007133476 A3 WO 2007133476A3 US 2007010806 W US2007010806 W US 2007010806W WO 2007133476 A3 WO2007133476 A3 WO 2007133476A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug bioavailability
increase drug
substrate inhibition
competitive substrate
bioavailability
Prior art date
Application number
PCT/US2007/010806
Other languages
French (fr)
Other versions
WO2007133476A2 (en
Inventor
Eric Holmes
Original Assignee
Scolr Pharma Inc
Eric Holmes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scolr Pharma Inc, Eric Holmes filed Critical Scolr Pharma Inc
Publication of WO2007133476A2 publication Critical patent/WO2007133476A2/en
Publication of WO2007133476A3 publication Critical patent/WO2007133476A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention is directed to a method and a composition for improving the bioavailability of an orally administered drug having poor systemic bioavailability, by competitively inhibiting and retarding the metabolic inactivation of the drug.
PCT/US2007/010806 2006-05-08 2007-05-04 Competitive substrate inhibition to increase drug bioavailability WO2007133476A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79859206P 2006-05-08 2006-05-08
US60/798,592 2006-05-08

Publications (2)

Publication Number Publication Date
WO2007133476A2 WO2007133476A2 (en) 2007-11-22
WO2007133476A3 true WO2007133476A3 (en) 2007-12-27

Family

ID=38694398

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/010806 WO2007133476A2 (en) 2006-05-08 2007-05-04 Competitive substrate inhibition to increase drug bioavailability

Country Status (2)

Country Link
TW (1) TW200808353A (en)
WO (1) WO2007133476A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102000078A (en) * 2010-10-25 2011-04-06 李一梅 Compound raloxifene hydrochloride tablets and preparation method thereof
CN108949946B (en) * 2017-05-25 2022-02-18 上海市预防医学研究院 UGT2 gene polymorphism site related to anti-tubercular drug hepatic injury and application thereof
CN111759820B (en) * 2020-08-24 2022-04-19 武汉人福药业有限责任公司 Oxcarbazepine tablet and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030215462A1 (en) * 2001-12-21 2003-11-20 Wacher Vincent J. Use of UGT inhibitors to increase bioavailability

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030215462A1 (en) * 2001-12-21 2003-11-20 Wacher Vincent J. Use of UGT inhibitors to increase bioavailability

Also Published As

Publication number Publication date
TW200808353A (en) 2008-02-16
WO2007133476A2 (en) 2007-11-22

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