WO2007132156A3 - Materials and methods relating to cancer diagnosis, prognosis and treatment based on the determination of novel molecular markers in tumors - Google Patents

Materials and methods relating to cancer diagnosis, prognosis and treatment based on the determination of novel molecular markers in tumors Download PDF

Info

Publication number
WO2007132156A3
WO2007132156A3 PCT/GB2007/001599 GB2007001599W WO2007132156A3 WO 2007132156 A3 WO2007132156 A3 WO 2007132156A3 GB 2007001599 W GB2007001599 W GB 2007001599W WO 2007132156 A3 WO2007132156 A3 WO 2007132156A3
Authority
WO
WIPO (PCT)
Prior art keywords
prognosis
cancer diagnosis
materials
tumors
determination
Prior art date
Application number
PCT/GB2007/001599
Other languages
French (fr)
Other versions
WO2007132156A2 (en
Inventor
Paolo Giovanni Nuciforo
Maria Capra
Stefano Confalonieri
Fiore Pier Paolo Di
Original Assignee
Ifom Fond Istituto Firc Di Onc
Cripps Joanna E
Paolo Giovanni Nuciforo
Maria Capra
Stefano Confalonieri
Fiore Pier Paolo Di
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ifom Fond Istituto Firc Di Onc, Cripps Joanna E, Paolo Giovanni Nuciforo, Maria Capra, Stefano Confalonieri, Fiore Pier Paolo Di filed Critical Ifom Fond Istituto Firc Di Onc
Publication of WO2007132156A2 publication Critical patent/WO2007132156A2/en
Publication of WO2007132156A3 publication Critical patent/WO2007132156A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides materials and methods for classifying tumours, for diagnosing and treating cancers and for determining a prognosis and/or treatment regimen for an individual with cancer. Serine/threonine kinases which show altered gene status and/or expression levels in tumour cells compared to normal cells are identified herein and these serine/threonine kinases provide specific tumour markers and tools for cancer diagnosis, prognosis and therapeutic applications.
PCT/GB2007/001599 2006-05-02 2007-05-02 Materials and methods relating to cancer diagnosis, prognosis and treatment based on the determination of novel molecular markers in tumors WO2007132156A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79651706P 2006-05-02 2006-05-02
US60/796,517 2006-05-02

Publications (2)

Publication Number Publication Date
WO2007132156A2 WO2007132156A2 (en) 2007-11-22
WO2007132156A3 true WO2007132156A3 (en) 2008-03-06

Family

ID=38543767

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/001599 WO2007132156A2 (en) 2006-05-02 2007-05-02 Materials and methods relating to cancer diagnosis, prognosis and treatment based on the determination of novel molecular markers in tumors

Country Status (1)

Country Link
WO (1) WO2007132156A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010043713A2 (en) * 2008-10-16 2010-04-22 Institut Municipal D'investigació Mèdica (Imim) Use of cyclin o in a medical setting
WO2013089278A1 (en) * 2011-12-14 2013-06-20 Taiho Pharmaceutical Co., Ltd. Recombinant prpk-tprkb and uses thereof
US10302644B2 (en) 2014-11-04 2019-05-28 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating multiple myeloma
CN108220431A (en) * 2016-12-14 2018-06-29 北京基石生命科技有限公司 Detect the primer pair of people EIF2AK1 gene expression amounts and relative expression quantity
CN114921546B (en) * 2022-05-13 2023-02-21 核工业总医院 Application of circHIPK2 as breast cancer biomarker

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003083096A2 (en) * 2002-03-28 2003-10-09 Qlt Inc. Cancer associated protein kinases and their uses
EP1365034A2 (en) * 2002-05-21 2003-11-26 Bayer Aktiengesellschaft Methods and compositions for the prediction, diagnosis, prognosis, prevention and treatment of malignant neoplasia
WO2004018641A2 (en) * 2002-08-26 2004-03-04 Incyte Corporation Kinases and phosphatases
WO2005026129A1 (en) * 2003-09-15 2005-03-24 Gpc Biotech Ag Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases
WO2005035724A2 (en) * 2003-10-08 2005-04-21 Avalon Pharmaceuticals, Inc Cancer-linked genes as targets for chemotherapy

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003083096A2 (en) * 2002-03-28 2003-10-09 Qlt Inc. Cancer associated protein kinases and their uses
US20050216961A1 (en) * 2002-03-28 2005-09-29 Delaney Allen D Cancer associated protein kinases and their uses
EP1365034A2 (en) * 2002-05-21 2003-11-26 Bayer Aktiengesellschaft Methods and compositions for the prediction, diagnosis, prognosis, prevention and treatment of malignant neoplasia
WO2004018641A2 (en) * 2002-08-26 2004-03-04 Incyte Corporation Kinases and phosphatases
WO2005026129A1 (en) * 2003-09-15 2005-03-24 Gpc Biotech Ag Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases
WO2005035724A2 (en) * 2003-10-08 2005-04-21 Avalon Pharmaceuticals, Inc Cancer-linked genes as targets for chemotherapy

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CAPRA MARIA ET AL: "Frequent alterations in the expression of serine/threonine kinases in human cancers", CANCER RESEARCH, vol. 66, no. 16, August 2006 (2006-08-01), pages 8147 - 8154, XP002454640, ISSN: 0008-5472 *
SEN S ET AL: "A PUTATIVE SERINE/THREONINE KINASE ENCODING GENE BTAK ON CHROMOSOME20Q13 IS AMPLIFIED AND OVEREXPRESSED IN HUMAN BREAST CANCER CELL LINES", ONCOGENE, BASINGSTOKE, HANTS, GB, vol. 14, 1997, pages 2195 - 2200, XP002917804, ISSN: 0950-9232 *
STEPHENS PHILIP ET AL: "A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer", NATURE GENETICS, vol. 37, no. 6, June 2005 (2005-06-01), pages 590 - 592, XP002454639, ISSN: 1061-4036 *
VEER VAN 'T L J ET AL: "Gene expression profiling predicts clinical outcome of breast cancer", NATURE, NATURE PUBLISHING GROUP, LONDON, GB, vol. 415, no. 6871, 31 January 2002 (2002-01-31), pages 530 - 536, XP002259781, ISSN: 0028-0836 *

Also Published As

Publication number Publication date
WO2007132156A2 (en) 2007-11-22

Similar Documents

Publication Publication Date Title
MX2010000405A (en) Drug selection for lung cancer therapy using antibody-based arrays.
IL207637A (en) Drug selection for breast cancer therapy using antibody-based arrays
Wu et al. Genetic variations in radiation and chemotherapy drug action pathways predict clinical outcomes in esophageal cancer
WO2007123772A3 (en) Genes involved in estrogen metabolism
WO2008063769A3 (en) Prostate cancer-specific alterations in erg gene expression and detection and treatment methods based on those alterations
WO2012153187A3 (en) Markers for cancer prognosis and therapy and methods of use
WO2011088149A3 (en) Methods for predicting response of triple-negative breast cancer to therapy
WO2007084992A3 (en) Prognosis and therapy predictive markers and methods of use
WO2008008500A3 (en) Methods for making cancer prognoses based on the subcellular localization of biomarkers
WO2006138275A3 (en) Compositions and methods for treating and diagnosing cancer
WO2006093507A3 (en) Methods and systems for predicting cancer outcome
WO2008039475A3 (en) A gene expression profiling based identification of genomic signatures of multiple myeloma and uses thereof
WO2008107134A3 (en) A method for detection of liver cancer, risk of liver cancer, risk of recurrence of liver cancer, malignancy of liver cancer and progression of liver cancer with time by using the methylated cytosine in basp1 gene and/or srd5a2 gene
WO2006089233A3 (en) Methods and systems for diagnosis, prognosis and selection of treatment of leukemia
WO2004097052A3 (en) Methods for prognosis and treatment of solid tumors
WO2006132683A3 (en) Reagents and methods for use in cancer diagnosis, classification and therapy
WO2008073878A3 (en) Gene expression profiling of esophageal carcinomas
EP2611941A4 (en) Gene signatures for cancer diagnosis and prognosis
WO2009083780A8 (en) Breast cancer expression profiling
WO2007112330A8 (en) Compositions and methods for detection, prognosis and treatment of colon cancer
WO2007134210A8 (en) Methods and compositions for the diagnosis and treatment of cancer
EP2540840A3 (en) Genetic variants on CHR16 as markers for use in breast cancer risk assessment, diagnosis, prognosis and treatment
WO2007143037A3 (en) Gene methylation in cancer diagnosis
MX2009013646A (en) Methods of diagnosing and treating cancer.
WO2007132156A3 (en) Materials and methods relating to cancer diagnosis, prognosis and treatment based on the determination of novel molecular markers in tumors

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07732632

Country of ref document: EP

Kind code of ref document: A2

DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 07732632

Country of ref document: EP

Kind code of ref document: A2