WO2007127173A4 - Therapeutic compounds - Google Patents

Therapeutic compounds Download PDF

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Publication number
WO2007127173A4
WO2007127173A4 PCT/US2007/009862 US2007009862W WO2007127173A4 WO 2007127173 A4 WO2007127173 A4 WO 2007127173A4 US 2007009862 W US2007009862 W US 2007009862W WO 2007127173 A4 WO2007127173 A4 WO 2007127173A4
Authority
WO
WIPO (PCT)
Prior art keywords
independently
compound
alkyl
alkoxy
formula
Prior art date
Application number
PCT/US2007/009862
Other languages
French (fr)
Other versions
WO2007127173A3 (en
WO2007127173A2 (en
Inventor
Edmond J Lavoie
Joseph E Rice
Leroy F Liu
Original Assignee
Univ Rutgers
Edmond J Lavoie
Joseph E Rice
Leroy F Liu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rutgers, Edmond J Lavoie, Joseph E Rice, Leroy F Liu filed Critical Univ Rutgers
Priority to CA002665818A priority Critical patent/CA2665818A1/en
Priority to EP07755933A priority patent/EP2079704A4/en
Publication of WO2007127173A2 publication Critical patent/WO2007127173A2/en
Priority to US12/258,208 priority patent/US8093235B2/en
Publication of WO2007127173A3 publication Critical patent/WO2007127173A3/en
Publication of WO2007127173A4 publication Critical patent/WO2007127173A4/en
Priority to US13/308,197 priority patent/US8518928B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

The invention provides compounds of formula I: wherein A, B, D, E, R1, R2, R3, R4, R5, X, and ----- have any values defined herein, as well as salts thereof. The compounds have activity as G-quadruplex DNA stabalizers and as anti-proliferative agents.

Claims

AMENDED CLAIMS Received by the International Bureau on 24.Oct.2008 (24.10.2008)
1. A compound of formula I:
Figure imgf000002_0001
wherein: each A7 B, D, and E is independently -C(=O)NH-CH(R8)-, -C(O)-NH-C(O)-, or a group of the foimula:
Figure imgf000002_0002
each R1, R2, R3, R4, and R5 is independently H, (C1-C6)alkyl, or (C1- C6)alkoxy. wherein each (C1-C6)alkyl and (C1-C6)alkoxy is optionally substituted with OH, (C1-C6)alkoxy, (C1-C6)alkylthio, aryl, NRcRd, or -C(=O)NRcRd; each R6, R7, and R8 is independently H; or each R6 and R7 together with the atoms to which they are attached form a benzo ring and R8 is H; or R6 is H and R7 and R8 together with the atoms to which they are attached form a benzo ring; each X is independently NH, S, or O; each Z is independently N or CH; the bond represented by ----- is a single or a double bond; each Ra is independently H, aryl, or (C1-C6)alkyl that is optionally substituted with OH, (C1-C6)alkoxy, (C1-C6)alkylthio, aryl, NReRf, or -C(=O)NReRf; each Rc and Rd is independently H or (C1-C6)alkyl; or Rc and Rd together with the nitrogen to which they are attached form a pyrrolidino, piperidino, piperazino, morpholino, thiomorpholino, or azepino ring; and each Re and Rf is independently H or (C1-C6)alkyl; or Re and Rf together with the nitrogen to which they are attached form a pyrrolidino, piperidino, piperazino, morpholino, thiomorpholino, or azepino ring; or a salt thereof; provided the compound of formula I is not telomestatin or dehydrotelomestatin.
2. The compound of claim 1 which is a compound of formula (II):
Figure imgf000003_0001
; or a pharmaceutically acceptable salt thereof.
3. The compound of claim 1 wherein A and D are each independently a group of the following formula:
Figure imgf000003_0002
4. The compound of claim 3 wherein each X is O; and the bond represented by----- is a double bond.
5. The compound of claim 4 wherein B and E are each independently -C(=O)NH-CH(Ra)-.
PCT/US2007/009862 2006-04-25 2007-04-24 Therapeutic compounds WO2007127173A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002665818A CA2665818A1 (en) 2006-04-25 2007-04-24 Therapeutic compounds
EP07755933A EP2079704A4 (en) 2006-04-25 2007-04-24 Therapeutic compounds
US12/258,208 US8093235B2 (en) 2006-04-25 2008-10-24 Macrocyclic compounds which stabilize G-Quadruplex DNA and RNA
US13/308,197 US8518928B2 (en) 2006-04-25 2011-11-30 Therapeutic compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79452506P 2006-04-25 2006-04-25
US60/794,525 2006-04-25

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/258,208 Continuation US8093235B2 (en) 2006-04-25 2008-10-24 Macrocyclic compounds which stabilize G-Quadruplex DNA and RNA

Publications (3)

Publication Number Publication Date
WO2007127173A2 WO2007127173A2 (en) 2007-11-08
WO2007127173A3 WO2007127173A3 (en) 2008-12-18
WO2007127173A4 true WO2007127173A4 (en) 2009-02-05

Family

ID=38656126

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/009862 WO2007127173A2 (en) 2006-04-25 2007-04-24 Therapeutic compounds

Country Status (3)

Country Link
EP (1) EP2079704A4 (en)
CA (1) CA2665818A1 (en)
WO (1) WO2007127173A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8093235B2 (en) 2006-04-25 2012-01-10 Rutgers, The State University Of New Jersey Macrocyclic compounds which stabilize G-Quadruplex DNA and RNA
WO2009018551A2 (en) 2007-08-02 2009-02-05 Rutgers, The State University Of New Jersey Therapeutic compounds
JP5476541B2 (en) * 2008-06-25 2014-04-23 国立大学法人東京農工大学 Telomerase inhibitor
CA2780145A1 (en) * 2009-11-05 2011-05-12 Rutgers, The State University Of New Jersey Therapeutic compounds
US20120302613A1 (en) * 2011-05-26 2012-11-29 Novobiotic Pharmaceuticals Llc Novel antibiotics

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050109958A (en) * 2003-03-04 2005-11-22 가부시키가이샤 소세이 Gm-95-containing antitumor effect potentiator, combined antitumor preparation and antitumor agent
JP4876220B2 (en) * 2005-05-13 2012-02-15 国立大学法人東京農工大学 Telomestatin derivatives

Also Published As

Publication number Publication date
EP2079704A4 (en) 2011-11-16
WO2007127173A3 (en) 2008-12-18
WO2007127173A2 (en) 2007-11-08
CA2665818A1 (en) 2007-11-08
EP2079704A2 (en) 2009-07-22

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