WO2007127173A3 - Therapeutic compounds - Google Patents

Therapeutic compounds Download PDF

Info

Publication number
WO2007127173A3
WO2007127173A3 PCT/US2007/009862 US2007009862W WO2007127173A3 WO 2007127173 A3 WO2007127173 A3 WO 2007127173A3 US 2007009862 W US2007009862 W US 2007009862W WO 2007127173 A3 WO2007127173 A3 WO 2007127173A3
Authority
WO
WIPO (PCT)
Prior art keywords
therapeutic compounds
compounds
stabalizers
salts
activity
Prior art date
Application number
PCT/US2007/009862
Other languages
French (fr)
Other versions
WO2007127173A4 (en
WO2007127173A2 (en
Inventor
Edmond J Lavoie
Joseph E Rice
Leroy F Liu
Original Assignee
Univ Rutgers
Edmond J Lavoie
Joseph E Rice
Leroy F Liu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rutgers, Edmond J Lavoie, Joseph E Rice, Leroy F Liu filed Critical Univ Rutgers
Priority to CA002665818A priority Critical patent/CA2665818A1/en
Priority to EP07755933A priority patent/EP2079704A4/en
Publication of WO2007127173A2 publication Critical patent/WO2007127173A2/en
Priority to US12/258,208 priority patent/US8093235B2/en
Publication of WO2007127173A3 publication Critical patent/WO2007127173A3/en
Publication of WO2007127173A4 publication Critical patent/WO2007127173A4/en
Priority to US13/308,197 priority patent/US8518928B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

The invention provides compounds of formula I: wherein A, B, D, E, R1, R2, R3, R4, R5, X, and ----- have any values defined herein, as well as salts thereof. The compounds have activity as G-quadruplex DNA stabalizers and as anti-proliferative agents.
PCT/US2007/009862 2006-04-25 2007-04-24 Therapeutic compounds WO2007127173A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002665818A CA2665818A1 (en) 2006-04-25 2007-04-24 Therapeutic compounds
EP07755933A EP2079704A4 (en) 2006-04-25 2007-04-24 Therapeutic compounds
US12/258,208 US8093235B2 (en) 2006-04-25 2008-10-24 Macrocyclic compounds which stabilize G-Quadruplex DNA and RNA
US13/308,197 US8518928B2 (en) 2006-04-25 2011-11-30 Therapeutic compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79452506P 2006-04-25 2006-04-25
US60/794,525 2006-04-25

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/258,208 Continuation US8093235B2 (en) 2006-04-25 2008-10-24 Macrocyclic compounds which stabilize G-Quadruplex DNA and RNA

Publications (3)

Publication Number Publication Date
WO2007127173A2 WO2007127173A2 (en) 2007-11-08
WO2007127173A3 true WO2007127173A3 (en) 2008-12-18
WO2007127173A4 WO2007127173A4 (en) 2009-02-05

Family

ID=38656126

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/009862 WO2007127173A2 (en) 2006-04-25 2007-04-24 Therapeutic compounds

Country Status (3)

Country Link
EP (1) EP2079704A4 (en)
CA (1) CA2665818A1 (en)
WO (1) WO2007127173A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8093235B2 (en) 2006-04-25 2012-01-10 Rutgers, The State University Of New Jersey Macrocyclic compounds which stabilize G-Quadruplex DNA and RNA
WO2009018551A2 (en) 2007-08-02 2009-02-05 Rutgers, The State University Of New Jersey Therapeutic compounds
JP5476541B2 (en) * 2008-06-25 2014-04-23 国立大学法人東京農工大学 Telomerase inhibitor
US8796300B2 (en) 2009-11-05 2014-08-05 Rutgers, The State University Of New Jersey Therapeutic compounds
JP2014516048A (en) * 2011-05-26 2014-07-07 ノボバイオティック ファーマシューティカルズ， エルエルシー New antibiotic

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2517850A1 (en) * 2003-03-04 2004-09-16 Sosei Co., Ltd. Gm-95-containing antitumor effect potentiator, combined antitumor preparation and antitumor agent
JP4876220B2 (en) * 2005-05-13 2012-02-15 国立大学法人東京農工大学 Telomestatin derivatives

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KIM ET AL., CANCER RESEARCH, 2003, pages 3247 - 3256, XP008104815 *
See also references of EP2079704A4 *

Also Published As

Publication number Publication date
CA2665818A1 (en) 2007-11-08
EP2079704A2 (en) 2009-07-22
EP2079704A4 (en) 2011-11-16
WO2007127173A4 (en) 2009-02-05
WO2007127173A2 (en) 2007-11-08

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