WO2007120198A3 - Matériaux et procédés de production améliorée de composés organiques - Google Patents

Matériaux et procédés de production améliorée de composés organiques Download PDF

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Publication number
WO2007120198A3
WO2007120198A3 PCT/US2006/043380 US2006043380W WO2007120198A3 WO 2007120198 A3 WO2007120198 A3 WO 2007120198A3 US 2006043380 W US2006043380 W US 2006043380W WO 2007120198 A3 WO2007120198 A3 WO 2007120198A3
Authority
WO
WIPO (PCT)
Prior art keywords
osmoprotectants
betaine
materials
methods
organic compounds
Prior art date
Application number
PCT/US2006/043380
Other languages
English (en)
Other versions
WO2007120198A2 (fr
Inventor
Lonnie O'neal Ingram
Keelnatham T Shanmugam
Shengde Zhou
Thomas B Causey
Lorraine P Yomano
Tammy B Grabar
Original Assignee
Univ Florida
Lonnie O'neal Ingram
Keelnatham T Shanmugam
Shengde Zhou
Thomas B Causey
Lorraine P Yomano
Tammy B Grabar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/501,137 external-priority patent/US7629162B2/en
Application filed by Univ Florida, Lonnie O'neal Ingram, Keelnatham T Shanmugam, Shengde Zhou, Thomas B Causey, Lorraine P Yomano, Tammy B Grabar filed Critical Univ Florida
Publication of WO2007120198A2 publication Critical patent/WO2007120198A2/fr
Publication of WO2007120198A3 publication Critical patent/WO2007120198A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/56—Lactic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention fait appel à des éléments protecteurs contre le stress osmotique, tels que la bétaïne, pour augmenter la productivité et le titre de fermentation anaérobie et aérobie de E. coli. et d'autres microbes. La bétaïne sert d'osmolyte protecteur au cours de fermentations en présence de concentrations élevées de sucres ou produits, supprimant la nécessité de transformer le carbone et l'énergie en éléments protecteurs natifs tels que le glutamate et le tréhalose. On peut par conséquent, selon l'invention, ajouter de la bétaïne et/ou d'autres éléments protecteurs contre le stress osmotique à des milieux afin d'améliorer la vitesse de conversion biologique des sucres en substances chimiques telles que des acides organiques.
PCT/US2006/043380 2005-11-08 2006-11-07 Matériaux et procédés de production améliorée de composés organiques WO2007120198A2 (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US73444305P 2005-11-08 2005-11-08
US60/734,443 2005-11-08
US76157606P 2006-01-24 2006-01-24
US60/761,576 2006-01-24
US79961906P 2006-05-11 2006-05-11
US60/799,619 2006-05-11
US11/501,137 2006-08-08
US11/501,137 US7629162B2 (en) 2005-08-10 2006-08-08 Materials and methods for efficient lactic acid production

Publications (2)

Publication Number Publication Date
WO2007120198A2 WO2007120198A2 (fr) 2007-10-25
WO2007120198A3 true WO2007120198A3 (fr) 2007-12-21

Family

ID=38609954

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/043380 WO2007120198A2 (fr) 2005-11-08 2006-11-07 Matériaux et procédés de production améliorée de composés organiques

Country Status (1)

Country Link
WO (1) WO2007120198A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101914581B (zh) * 2010-07-27 2012-05-23 南京工业大学 一种提高多烯不饱和脂肪酸发酵产量的方法
NL2007353C2 (en) * 2011-09-05 2013-03-07 Kwr Water B V Solution comprising an osmotic agent and method of extracting water using said solution.
US10208324B2 (en) 2013-12-13 2019-02-19 Basf Se Recombinant microorganism for improved production of fine chemicals
CN106574236B (zh) 2014-07-23 2020-12-11 普拉克生化公司 遗传修饰的产生(r)-乳酸的嗜热细菌
EP3271467A1 (fr) 2015-03-18 2018-01-24 Basf Se Micro-organisme recombinant pour la production améliorée de produits chimiques fins
BR112017025923A2 (pt) 2015-06-04 2018-08-14 Basf Se molécula de ácido nucleico recombinante, molécula de aminoácido recombinante, construto de expressão recombinante, vetor recombinante, micro-organismo recombinante, composição, métodos para produção de um micro-organismo recombinante e para cultivo e crescimento de um micro-organismo geneticamente modificado, uso de uma molécula de ácido nucleico recombinante, e, processo para produção fermentativa de um composto.
EP3307902A1 (fr) 2015-06-12 2018-04-18 Basf Se Micro-organisme de recombinaison pour la production améliorée d'alanine

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4818268A (en) * 1985-09-16 1989-04-04 Spawn Mate, Inc. Osmoprotectant

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4818268A (en) * 1985-09-16 1989-04-04 Spawn Mate, Inc. Osmoprotectant

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CAYLEY S. ET AL.: "Origins of the osmoprotective properties of betaine and proline in Escherichia coli K-12", J. BACTERIOL., vol. 174, no. 5, 1992, pages 1586 - 1595 *
PURVIS J.E. ET AL.: "Enhanced trehalose production improves growth of Escherichia coli under osmotic stress", APPL. ENVIRON. MICROBIOL., vol. 71, no. 7, July 2005 (2005-07-01), pages 3761 - 3769 *
UNDERWOOD S.A. ET AL.: "Lack of protective osmolytes limits final cell density and volumetric productivity of ethanologenic Escherichia coli KO11 during xylose fermentation", APPL. ENVIRON. MICROBIOL., vol. 70, no. 5, 2004, pages 2734 - 2740 *
ZHOU S. ET AL.: "Betaine tripled the volumetric productivity of D(-)-lactate by Escherichia coli strain SZ132 in mineral salts medium", BIOTECHNOL. LETT., vol. 28, no. 9, May 2006 (2006-05-01), pages 671 - 676 *
ZHOU S. ET AL.: "Production of optically pure D-lactic acid in mineral salts medium by metabolically engineered Escherichia coli W3110", APPL. ENVIRON. MICROBIOL., vol. 69, no. 1, 2003, pages 399 - 407 *

Also Published As

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