WO2007114922A3 - Salts of 8-[{1-(3,5-bis-(trifluoromethyl) phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one and preparation process therefor - Google Patents

Salts of 8-[{1-(3,5-bis-(trifluoromethyl) phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one and preparation process therefor Download PDF

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Publication number
WO2007114922A3
WO2007114922A3 PCT/US2007/008346 US2007008346W WO2007114922A3 WO 2007114922 A3 WO2007114922 A3 WO 2007114922A3 US 2007008346 W US2007008346 W US 2007008346W WO 2007114922 A3 WO2007114922 A3 WO 2007114922A3
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WO
WIPO (PCT)
Prior art keywords
phenyl
decan
trifluoromethyl
ethoxy
bis
Prior art date
Application number
PCT/US2007/008346
Other languages
French (fr)
Other versions
WO2007114922A2 (en
Inventor
Mengwei Hu
Sunil Paliwal
Neng-Yang Shih
Frank Guenter
Ingrid Mergelsberg
Original Assignee
Schering Corp
Mengwei Hu
Sunil Paliwal
Neng-Yang Shih
Frank Guenter
Ingrid Mergelsberg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp, Mengwei Hu, Sunil Paliwal, Neng-Yang Shih, Frank Guenter, Ingrid Mergelsberg filed Critical Schering Corp
Publication of WO2007114922A2 publication Critical patent/WO2007114922A2/en
Publication of WO2007114922A3 publication Critical patent/WO2007114922A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Disclosed are crystalline salt forms of (5S,8S)-8-[{(1 R)-1-(3,5-Bis- (trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-d;diazaspiro[4.5]decan-2-one, represented by Formula I and methods of preparing the same.
PCT/US2007/008346 2006-04-05 2007-04-04 Salts of 8-[{1-(3,5-bis-(trifluoromethyl) phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one and preparation process therefor WO2007114922A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78951306P 2006-04-05 2006-04-05
US60/789,513 2006-04-05

Publications (2)

Publication Number Publication Date
WO2007114922A2 WO2007114922A2 (en) 2007-10-11
WO2007114922A3 true WO2007114922A3 (en) 2008-01-17

Family

ID=38470135

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/008346 WO2007114922A2 (en) 2006-04-05 2007-04-04 Salts of 8-[{1-(3,5-bis-(trifluoromethyl) phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one and preparation process therefor

Country Status (5)

Country Link
AR (1) AR060352A1 (en)
CL (1) CL2007000947A1 (en)
PE (1) PE20080353A1 (en)
TW (1) TW200806666A (en)
WO (1) WO2007114922A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2648604C (en) 2006-04-05 2016-05-24 Schering Corporation Hydrochloride salts of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one and preparation process therefor
AR066191A1 (en) 2007-03-22 2009-08-05 Schering Corp PROCESS AND INTERMEDIARIES FOR THE SYNTHESIS OF COMPOUNDS 8- [(1- (3,5- BIS- (TRIFLUOROMETIL) PHENYL) - ETOXI) - METAL] - 8 PHENYL - 1,7- DIAZA - ESPIRO (4, 5) DECAN - 2 ONA
AU2009289598B2 (en) * 2008-09-05 2014-09-11 Opko Health, Inc. Process and intermediates for the synthesis of 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl) -ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds
CN105017251B (en) * 2015-06-30 2018-06-29 齐鲁制药有限公司 A kind of Preparation Method And Their Intermediate of nk 1 receptor antagonist

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030158173A1 (en) * 2001-12-18 2003-08-21 Schering Corporation NK 1 antagonists
WO2005063243A1 (en) * 2003-12-22 2005-07-14 Schering Corporation Pharmaceutical compositions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030158173A1 (en) * 2001-12-18 2003-08-21 Schering Corporation NK 1 antagonists
WO2005063243A1 (en) * 2003-12-22 2005-07-14 Schering Corporation Pharmaceutical compositions

Also Published As

Publication number Publication date
TW200806666A (en) 2008-02-01
WO2007114922A2 (en) 2007-10-11
CL2007000947A1 (en) 2008-01-25
AR060352A1 (en) 2008-06-11
PE20080353A1 (en) 2008-04-25

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