AR060352A1 - SALTS OF 8- [(1- (3,5-BIS- (TRIFLUOROMETIL) PHENYL) -ETOXI) -METIL] -8-PHENYL-1,7 -DIAZA- ESPIRO [4.5] DECAN -2-ONA AND PREPARATION PROCESS FROM THE SAME - Google Patents

SALTS OF 8- [(1- (3,5-BIS- (TRIFLUOROMETIL) PHENYL) -ETOXI) -METIL] -8-PHENYL-1,7 -DIAZA- ESPIRO [4.5] DECAN -2-ONA AND PREPARATION PROCESS FROM THE SAME

Info

Publication number
AR060352A1
AR060352A1 ARP070101435A ARP070101435A AR060352A1 AR 060352 A1 AR060352 A1 AR 060352A1 AR P070101435 A ARP070101435 A AR P070101435A AR P070101435 A ARP070101435 A AR P070101435A AR 060352 A1 AR060352 A1 AR 060352A1
Authority
AR
Argentina
Prior art keywords
phenyl
decan
diaza
bis
espiro
Prior art date
Application number
ARP070101435A
Other languages
Spanish (es)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of AR060352A1 publication Critical patent/AR060352A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics

Abstract

Una forma de la sal cristalina de esilato de (5S,8S)-8-[{(1R)-1-(3,5-Bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diaza-espiro[4.5]decan-2-ona de formula 1; la cual se caracteriza por el siguiente patron de difraccion de rayos X sobre muestras de polvo expresado en términos del ángulo de difraccion (en 2 Q, espaciado ôdö de retícula (en angstroms) e intensidades de pico relativo (Rl): Ángulo de difraccion (2Q Rl Espacio de retícula (L +- 0.04) 11.4 Medias 7.73 12.8 Medias 6.90 20.0 Medias 4.44 21.2 Medias 18A form of the crystalline salt of (5S, 8S) -8 - [{(1R) -1- (3,5-Bis- (trifluoromethyl) phenyl) -ethoxy} -methyl] -8-phenyl-1, 7-diaza-spiro [4.5] decan-2-one of formula 1; which is characterized by the following pattern of diffraction of X-rays on samples of dust expressed in terms of the angle of diffraction (in 2 Q, spacing ôdö of reticulum (in angstroms) and intensities of relative peak (Rl): Angle of diffraction ( 2Q Rl Grid space (L + - 0.04) 11.4 Averages 7.73 12.8 Averages 6.90 20.0 Averages 4.44 21.2 Averages 18

ARP070101435A 2006-04-05 2007-04-04 SALTS OF 8- [(1- (3,5-BIS- (TRIFLUOROMETIL) PHENYL) -ETOXI) -METIL] -8-PHENYL-1,7 -DIAZA- ESPIRO [4.5] DECAN -2-ONA AND PREPARATION PROCESS FROM THE SAME AR060352A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78951306P 2006-04-05 2006-04-05

Publications (1)

Publication Number Publication Date
AR060352A1 true AR060352A1 (en) 2008-06-11

Family

ID=38470135

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070101435A AR060352A1 (en) 2006-04-05 2007-04-04 SALTS OF 8- [(1- (3,5-BIS- (TRIFLUOROMETIL) PHENYL) -ETOXI) -METIL] -8-PHENYL-1,7 -DIAZA- ESPIRO [4.5] DECAN -2-ONA AND PREPARATION PROCESS FROM THE SAME

Country Status (5)

Country Link
AR (1) AR060352A1 (en)
CL (1) CL2007000947A1 (en)
PE (1) PE20080353A1 (en)
TW (1) TW200806666A (en)
WO (1) WO2007114922A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102276606B (en) 2006-04-05 2013-06-12 欧科生医股份有限公司 Tosylate crystalline salts of 8-[{1-(3,5-bis-(trifluoromethyl) phenyl) -ethoxy}-methyl] -8-phenyl-1,7-diaza-spiro[4.5] decan-2-one and preparation process therefor
AR066191A1 (en) 2007-03-22 2009-08-05 Schering Corp PROCESS AND INTERMEDIARIES FOR THE SYNTHESIS OF COMPOUNDS 8- [(1- (3,5- BIS- (TRIFLUOROMETIL) PHENYL) - ETOXI) - METAL] - 8 PHENYL - 1,7- DIAZA - ESPIRO (4, 5) DECAN - 2 ONA
CN102203062B (en) 2008-09-05 2014-12-17 欧科生医股份有限公司 Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds
CN105017251B (en) * 2015-06-30 2018-06-29 齐鲁制药有限公司 A kind of Preparation Method And Their Intermediate of nk 1 receptor antagonist

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20030762A1 (en) * 2001-12-18 2003-09-05 Schering Corp HETEROCYCLIC COMPOUNDS AS NK1 ANTAGONISTS
US20050153999A1 (en) * 2003-12-22 2005-07-14 Schering Corporation Pharmaceutical compositions

Also Published As

Publication number Publication date
CL2007000947A1 (en) 2008-01-25
TW200806666A (en) 2008-02-01
PE20080353A1 (en) 2008-04-25
WO2007114922A2 (en) 2007-10-11
WO2007114922A3 (en) 2008-01-17

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