WO2007113644A3 - New hdac inhibitors - Google Patents

New hdac inhibitors Download PDF

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Publication number
WO2007113644A3
WO2007113644A3 PCT/IB2007/000853 IB2007000853W WO2007113644A3 WO 2007113644 A3 WO2007113644 A3 WO 2007113644A3 IB 2007000853 W IB2007000853 W IB 2007000853W WO 2007113644 A3 WO2007113644 A3 WO 2007113644A3
Authority
WO
WIPO (PCT)
Prior art keywords
hdac
general formula
hdac inhibitors
present
novel compounds
Prior art date
Application number
PCT/IB2007/000853
Other languages
French (fr)
Other versions
WO2007113644A2 (en
Inventor
Akella Satya Surya Visweswara Srinivas
Virendra Kachhadia
Kasinathan Mathiyazhagan
Sathya Narayana Thara
Lakshmanan Manikandan
Sriram Rajagopal
Gaddam Om Reddy
Original Assignee
Orchid Res Lab Ltd
Akella Satya Surya Visweswara Srinivas
Virendra Kachhadia
Kasinathan Mathiyazhagan
Sathya Narayana Thara
Lakshmanan Manikandan
Sriram Rajagopal
Gaddam Om Reddy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orchid Res Lab Ltd, Akella Satya Surya Visweswara Srinivas, Virendra Kachhadia, Kasinathan Mathiyazhagan, Sathya Narayana Thara, Lakshmanan Manikandan, Sriram Rajagopal, Gaddam Om Reddy filed Critical Orchid Res Lab Ltd
Publication of WO2007113644A2 publication Critical patent/WO2007113644A2/en
Publication of WO2007113644A3 publication Critical patent/WO2007113644A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to novel compounds of the general formula (I), having histone deacetylase (HDAC) inhibiting enzymatic activity, their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof. The present invention more particularly provides novel compounds of the general formula (I). Also included is a method for treatment of cancer, psoriasis, proliferative conditions and conditions mediated by HDAC, in a mammal comprising administering an effective amount of a novel compound of formula (I) as described above.
PCT/IB2007/000853 2006-04-05 2007-04-03 New hdac inhibitors WO2007113644A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN629CH2006 2006-04-05
IN629/CHE/2006 2006-04-05

Publications (2)

Publication Number Publication Date
WO2007113644A2 WO2007113644A2 (en) 2007-10-11
WO2007113644A3 true WO2007113644A3 (en) 2009-06-04

Family

ID=38564025

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/000853 WO2007113644A2 (en) 2006-04-05 2007-04-03 New hdac inhibitors

Country Status (1)

Country Link
WO (1) WO2007113644A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101384350B1 (en) * 2012-06-21 2014-04-14 충북대학교 산학협력단 Novel Hydroxamic Acids Having Histone Deacetylase Inhibiting Activity and Anti-Cancer Composition Comprising the Same As An Active Ingredient

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4122186A (en) * 1976-03-23 1978-10-24 Laboratoire L. Lafon Acetohydroxamic acids
WO1993007148A1 (en) * 1991-10-04 1993-04-15 Sloan-Kettering Institute For Cancer Research Novel potent inducers of terminal differentiation and methods of use thereof
WO2000034269A1 (en) * 1998-12-09 2000-06-15 American Home Products Corporation Thiourea inhibitors of herpes viruses
WO2001018171A2 (en) * 1999-09-08 2001-03-15 Sloan-Kettering Institute For Cancer Research Novel class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof
WO2002026696A1 (en) * 2000-09-29 2002-04-04 Prolifix Limited Carbamic acid compounds comprising an amide linkage as hdac inhibitors
WO2004043352A2 (en) * 2002-11-12 2004-05-27 Alcon, Inc. Histone deacetylase inhibitors for the treatment of ocular neovascular or edematous disorders and diseases
US20050119305A1 (en) * 2001-03-21 2005-06-02 Masao Naka Il-6 production inhibitors
JP2005272419A (en) * 2004-03-26 2005-10-06 Nippon Kayaku Co Ltd Histon deacetylase inhibitor
WO2005097747A1 (en) * 2004-04-05 2005-10-20 Aton Pharma, Inc. Histone deacetylase inhibitor prodrugs

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4122186A (en) * 1976-03-23 1978-10-24 Laboratoire L. Lafon Acetohydroxamic acids
WO1993007148A1 (en) * 1991-10-04 1993-04-15 Sloan-Kettering Institute For Cancer Research Novel potent inducers of terminal differentiation and methods of use thereof
WO2000034269A1 (en) * 1998-12-09 2000-06-15 American Home Products Corporation Thiourea inhibitors of herpes viruses
WO2001018171A2 (en) * 1999-09-08 2001-03-15 Sloan-Kettering Institute For Cancer Research Novel class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof
WO2002026696A1 (en) * 2000-09-29 2002-04-04 Prolifix Limited Carbamic acid compounds comprising an amide linkage as hdac inhibitors
US20050119305A1 (en) * 2001-03-21 2005-06-02 Masao Naka Il-6 production inhibitors
WO2004043352A2 (en) * 2002-11-12 2004-05-27 Alcon, Inc. Histone deacetylase inhibitors for the treatment of ocular neovascular or edematous disorders and diseases
JP2005272419A (en) * 2004-03-26 2005-10-06 Nippon Kayaku Co Ltd Histon deacetylase inhibitor
WO2005097747A1 (en) * 2004-04-05 2005-10-20 Aton Pharma, Inc. Histone deacetylase inhibitor prodrugs

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE CAPLUS BHARGAVA, P.N., ET AL.: "Synthesis of new local anesthetics", Database accession no. 1962:483218 *
J. IND. CHEM. SOC., vol. 39, 1962, pages 396 - 8 *

Also Published As

Publication number Publication date
WO2007113644A2 (en) 2007-10-11

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