WO2007107706A3 - Multimeres de composes heterocycliques et leur utilisation - Google Patents
Multimeres de composes heterocycliques et leur utilisation Download PDFInfo
- Publication number
- WO2007107706A3 WO2007107706A3 PCT/GB2007/000919 GB2007000919W WO2007107706A3 WO 2007107706 A3 WO2007107706 A3 WO 2007107706A3 GB 2007000919 W GB2007000919 W GB 2007000919W WO 2007107706 A3 WO2007107706 A3 WO 2007107706A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- dimers
- treatment
- copd
- heterocyclic compounds
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne des conjugués covalents de deux composés ou plus, chacun doté d'une structure telle que définie dans l'un des documents WO2004/043924, WO2005/021509, WO2005/021512, WO2005/026123, WO2005/026124, WO2006/098683 et WO2006/098684. Lesdits conjugués sont des inhibiteurs de l'élastase neutrophile humaine et sont notamment utiles dans le traitement de la bronchopneumopathie chronique obstructive. L'invention concerne des dimères de formule (IA) ou (IB): dans lesquelles le LIEUR et les substituants variables sont des types particuliers desdits multimères.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0605469.6A GB0605469D0 (en) | 2006-03-17 | 2006-03-17 | Multimers of heterocyclic compounds and their use |
GB0605469.6 | 2006-03-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007107706A2 WO2007107706A2 (fr) | 2007-09-27 |
WO2007107706A3 true WO2007107706A3 (fr) | 2008-10-09 |
Family
ID=36293016
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2007/000919 WO2007107706A2 (fr) | 2006-03-17 | 2007-03-16 | Multimeres de composes heterocycliques et leur utilisation |
Country Status (2)
Country | Link |
---|---|
GB (1) | GB0605469D0 (fr) |
WO (1) | WO2007107706A2 (fr) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0302486D0 (sv) | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
TW200808771A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds II |
TW200808763A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds I |
EP2064184A1 (fr) * | 2006-09-04 | 2009-06-03 | AstraZeneca AB | Composés hétérocycliques multimériques utilisés comme inhibiteurs de l'élastase neutrophile |
WO2009037413A1 (fr) * | 2007-09-19 | 2009-03-26 | Argenta Discovery Limited | Dimères de 5-[(4-cyanophényl)sulfinyl]-6-méthyl-2-oxo-1-[3-(trifluorométhyl)phényl]-1,2-dihydropyridine-3-carboxamide en tant qu'inhibiteurs de l'élastase des neutrophiles humains pour traiter des maladies respiratoires |
CL2008003301A1 (es) | 2007-11-06 | 2009-10-16 | Astrazeneca Ab | Compuestos derivados de 3,4-dihidropirazina-2-carboxamida, inhibidores de la elastasa de neutrofilos humanos; composiciones farmacéuticas; procesos de preparación de compuestos y composición farmacéutica; y uso en el tratamiento de síndrome de dificultad respiratoria de los adultos, fibrosis quística, cáncer, entre otras. |
TW201036957A (en) | 2009-02-20 | 2010-10-16 | Astrazeneca Ab | Novel salt 628 |
WO2011039528A1 (fr) * | 2009-10-02 | 2011-04-07 | Astrazeneca Ab | Composés 2-pyridones utilisés comme inhibiteurs d'élastase de neutrophile |
CN105518000B (zh) | 2013-07-02 | 2018-09-14 | 加州生物医学研究所 | 用于治疗囊性纤维化的化合物 |
US9221807B2 (en) * | 2014-02-21 | 2015-12-29 | Boehringer Ingelheim International Gmbh | Substituted pyridones and pyrazinones and their use as inhibitors of neutrophil elastase activity |
WO2015179823A2 (fr) * | 2014-05-23 | 2015-11-26 | The California Institute For Biomedical Research | Inhibiteurs d'alpha (v) bêta 6, localisés dans les poumons |
US9487528B2 (en) * | 2014-06-09 | 2016-11-08 | Chiesi Farmaceutici S.P.A. | Compounds |
WO2015188866A1 (fr) * | 2014-06-12 | 2015-12-17 | Chiesi Farmaceutici S.P.A. | Nouveaux composés |
WO2015200349A2 (fr) * | 2014-06-24 | 2015-12-30 | The California Institute For Biomedical Research | Inhibiteurs de l'élastase |
CN107405505A (zh) * | 2015-01-07 | 2017-11-28 | 加州生物医学研究所 | 用于治疗囊性纤维化的化合物 |
US9802919B1 (en) * | 2016-05-31 | 2017-10-31 | Chiesi Farmaceutici S.P.A. | Compounds |
CN114650819A (zh) | 2019-09-17 | 2022-06-21 | 美莱奥生物制药第四有限公司 | 用于治疗移植物排斥、闭塞性细支气管炎综合征和移植物抗宿主病的阿维来司他 |
IL297211A (en) | 2020-04-16 | 2022-12-01 | Mereo Biopharma 4 Ltd | Methods involving the neutrophil elastase inhibitor albalstat for the treatment of respiratory disease mediated by alpha-1 antitrypsin deficiency |
AU2022373971A1 (en) | 2021-10-20 | 2024-04-04 | Mereo Biopharma 4 Limited | Neutrophil elastase inhibitors for use in the treatment of fibrosis |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004043924A1 (fr) * | 2002-11-12 | 2004-05-27 | Astrazeneca Ab | Derives de 2-pyridone en tant qu'inhibiteurs de l'elastase de neutrophile |
WO2005021512A1 (fr) * | 2003-08-28 | 2005-03-10 | Astrazeneca Ab | Derives de quinoxaline utilises comme inhibiteurs de l'elastase neutrophile et leur utilisation |
WO2005021509A1 (fr) * | 2003-08-28 | 2005-03-10 | Astrazeneca Ab | Derives de quinoline utilises comme inhibiteurs de l'elastase neutrophile et utilisation de ces derives |
WO2005026123A1 (fr) * | 2003-09-18 | 2005-03-24 | Astrazeneca Ab | Derives de 2-pyridone utilises en tant q'inhibiteurs de l'elastase neutrophile et utilisations de ceux-ci |
WO2005026124A1 (fr) * | 2003-09-18 | 2005-03-24 | Astrazeneca Ab | Derives 2-pyridone utilises comme inhibiteurs d'elastase neutrophile et utilisation de ceux-ci |
WO2008030158A1 (fr) * | 2006-09-04 | 2008-03-13 | Astrazeneca Ab | Composés hétérocycliques multimériques utilisés comme inhibiteurs de l'élastase neutrophile |
-
2006
- 2006-03-17 GB GBGB0605469.6A patent/GB0605469D0/en not_active Ceased
-
2007
- 2007-03-16 WO PCT/GB2007/000919 patent/WO2007107706A2/fr active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004043924A1 (fr) * | 2002-11-12 | 2004-05-27 | Astrazeneca Ab | Derives de 2-pyridone en tant qu'inhibiteurs de l'elastase de neutrophile |
WO2005021512A1 (fr) * | 2003-08-28 | 2005-03-10 | Astrazeneca Ab | Derives de quinoxaline utilises comme inhibiteurs de l'elastase neutrophile et leur utilisation |
WO2005021509A1 (fr) * | 2003-08-28 | 2005-03-10 | Astrazeneca Ab | Derives de quinoline utilises comme inhibiteurs de l'elastase neutrophile et utilisation de ces derives |
WO2005026123A1 (fr) * | 2003-09-18 | 2005-03-24 | Astrazeneca Ab | Derives de 2-pyridone utilises en tant q'inhibiteurs de l'elastase neutrophile et utilisations de ceux-ci |
WO2005026124A1 (fr) * | 2003-09-18 | 2005-03-24 | Astrazeneca Ab | Derives 2-pyridone utilises comme inhibiteurs d'elastase neutrophile et utilisation de ceux-ci |
WO2008030158A1 (fr) * | 2006-09-04 | 2008-03-13 | Astrazeneca Ab | Composés hétérocycliques multimériques utilisés comme inhibiteurs de l'élastase neutrophile |
Non-Patent Citations (1)
Title |
---|
HAN YI FAN ET AL: "Dual-site binding of bivalent 4-aminopyridine- and 4-aminoquinoline-based AChE inhibitors: contribution of the hydrophobic alkylene tether to monomer and dimer affinities", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 7, no. 11, 1 January 1999 (1999-01-01), pages 2569 - 2575, XP002365936, ISSN: 0968-0896 * |
Also Published As
Publication number | Publication date |
---|---|
GB0605469D0 (en) | 2006-04-26 |
WO2007107706A2 (fr) | 2007-09-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2007107706A3 (fr) | Multimeres de composes heterocycliques et leur utilisation | |
IL250847A0 (en) | 5-substituted quinazolinone derivatives as anticancer agents | |
WO2007021937A3 (fr) | Derives heterocycliques insatures | |
WO2007087395A3 (fr) | INHIBITEURS DE mTOR INSATURES | |
WO2008024978A3 (fr) | Dérivés de benzène, de pyridine et de pyridazine | |
EP2057158B8 (fr) | Dérivés de triazole en tant qu'inhibiteurs de kinase | |
WO2009036092A9 (fr) | Agents antitumoraux ciblant les mitochondries | |
DE602007003074D1 (de) | Neue pyrinderivate | |
PT2044036E (pt) | Derivados de [4,5′]bipirimidinil-6,4′-diamina como inibidores de proteína quinase | |
WO2010038086A3 (fr) | Nouveaux composés | |
WO2009155121A3 (fr) | Inhibiteurs de la pi3 kinase | |
TW200740776A (en) | N-phenylbenzotriazolyl c-kit inhibitors | |
WO2008048867A3 (fr) | Composés hétoroaromatiques bicycliques | |
WO2007015017A3 (fr) | Nouveaux derives de polyquinoleines et leur utilisation therapeutique | |
WO2007143434A3 (fr) | Activateurs de glucokinase | |
MX2009009774A (es) | Derivados de quinolina como fungicidas. | |
WO2009087098A3 (fr) | Fongicides | |
WO2008053194A3 (fr) | Composés chimiques | |
WO2010058032A3 (fr) | Nouveaux composés | |
WO2007115620A3 (fr) | Nouveaux composés de cyclobutyle en tant qu'inhibiteurs de kinase | |
WO2008001195A3 (fr) | Nouveaux procédés de synthèse d'inhibiteurs de dpp iv | |
MX2009003081A (es) | Derivados de pirrola utiles para el tratamiento de enfermedades mediadas por citoquinas. | |
WO2008152014A3 (fr) | Nouveaux composés | |
WO2007097981A3 (fr) | Alpha carbolines et leurs utilisations | |
WO2008008700A3 (fr) | Composés thérapeutiques |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 07712911 Country of ref document: EP Kind code of ref document: A2 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 07712911 Country of ref document: EP Kind code of ref document: A2 |