WO2007106915A3 - Antibodies to egfl7 and methods for their use - Google Patents

Antibodies to egfl7 and methods for their use Download PDF

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Publication number
WO2007106915A3
WO2007106915A3 PCT/US2007/064242 US2007064242W WO2007106915A3 WO 2007106915 A3 WO2007106915 A3 WO 2007106915A3 US 2007064242 W US2007064242 W US 2007064242W WO 2007106915 A3 WO2007106915 A3 WO 2007106915A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibodies
methods
egfl7
compositons
provides anti
Prior art date
Application number
PCT/US2007/064242
Other languages
French (fr)
Other versions
WO2007106915A2 (en
WO2007106915A8 (en
Inventor
Weilan Ye
Maike Schmidt
Jo-Anne Hongo
Yan Wu
Original Assignee
Genentech Inc
Weilan Ye
Maike Schmidt
Jo-Anne Hongo
Yan Wu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US12/280,673 priority Critical patent/US20100203041A1/en
Priority to UAA200812195A priority patent/UA97360C2/en
Priority to NZ570588A priority patent/NZ570588A/en
Priority to CA002646513A priority patent/CA2646513A1/en
Priority to BRPI0707047-0A priority patent/BRPI0707047A2/en
Priority to EP07800145.0A priority patent/EP1994056B1/en
Priority to MX2008011663A priority patent/MX2008011663A/en
Priority to AU2007226522A priority patent/AU2007226522B2/en
Priority to JP2009500633A priority patent/JP5363972B2/en
Application filed by Genentech Inc, Weilan Ye, Maike Schmidt, Jo-Anne Hongo, Yan Wu filed Critical Genentech Inc
Publication of WO2007106915A2 publication Critical patent/WO2007106915A2/en
Publication of WO2007106915A8 publication Critical patent/WO2007106915A8/en
Publication of WO2007106915A3 publication Critical patent/WO2007106915A3/en
Priority to IL193514A priority patent/IL193514A0/en
Priority to NO20084320A priority patent/NO20084320L/en
Priority to US13/087,247 priority patent/US8398976B2/en
Priority to IL223416A priority patent/IL223416A0/en
Priority to US13/755,950 priority patent/US20130129735A1/en
Priority to PH12013502194A priority patent/PH12013502194A1/en
Priority to IL232011A priority patent/IL232011A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides anti-EGFL7 antibodies, and compositons comprising and methods of using these antibodies.
PCT/US2007/064242 2006-03-16 2007-03-16 Antibodies to egfl7 and methods for their use WO2007106915A2 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
UAA200812195A UA97360C2 (en) 2006-03-16 2007-03-16 Antibodies to egfl7 and methods for their use
NZ570588A NZ570588A (en) 2006-03-16 2007-03-16 Antibodies to EGFL7 and methods for their use
CA002646513A CA2646513A1 (en) 2006-03-16 2007-03-16 Antibodies to egfl7 and methods for their use
BRPI0707047-0A BRPI0707047A2 (en) 2006-03-16 2007-03-16 hybridoma antibody, isolated antibodies, polynucleotide pharmaceutical composition, vector, host cell, method of producing an antibody, method of reducing or inhibiting angiogenesis, and method of increasing the effectiveness of an anti-angiogenic agent
EP07800145.0A EP1994056B1 (en) 2006-03-16 2007-03-16 Antibodies to egfl7 and methods for their use
US12/280,673 US20100203041A1 (en) 2006-03-16 2007-03-16 Antibodies to egfl7 and methods for their use
MX2008011663A MX2008011663A (en) 2006-03-16 2007-03-16 Antibodies to egfl7 and methods for their use.
AU2007226522A AU2007226522B2 (en) 2006-03-16 2007-03-16 Antibodies to EGFL7 and methods for their use
JP2009500633A JP5363972B2 (en) 2006-03-16 2007-03-16 Antibodies against EGFL7 and methods of use thereof
IL193514A IL193514A0 (en) 2006-03-16 2008-08-18 Antibodies to egfl7 and methods for their use
NO20084320A NO20084320L (en) 2006-03-16 2008-10-15 Antibodies to EGFL7 and methods for their use
US13/087,247 US8398976B2 (en) 2006-03-16 2011-04-14 Antibodies to EGFL7 and methods for their use
IL223416A IL223416A0 (en) 2006-03-16 2012-12-04 Antibodies to egfl7 and methods for their use
US13/755,950 US20130129735A1 (en) 2006-03-16 2013-01-31 Antibodies to egfl7 and methods for their use
PH12013502194A PH12013502194A1 (en) 2006-03-16 2013-10-23 Antibodies to egfl7 and methods for their use
IL232011A IL232011A0 (en) 2006-03-16 2014-04-08 Antibodies to egfl7 and methods for their use

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US78368606P 2006-03-16 2006-03-16
US60/783,686 2006-03-16
US81256906P 2006-06-09 2006-06-09
US60/812,569 2006-06-09

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/280,673 A-371-Of-International US20100203041A1 (en) 2006-03-16 2007-03-16 Antibodies to egfl7 and methods for their use
US13/087,247 Continuation US8398976B2 (en) 2006-03-16 2011-04-14 Antibodies to EGFL7 and methods for their use

Publications (3)

Publication Number Publication Date
WO2007106915A2 WO2007106915A2 (en) 2007-09-20
WO2007106915A8 WO2007106915A8 (en) 2007-11-22
WO2007106915A3 true WO2007106915A3 (en) 2008-06-05

Family

ID=38510306

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/064242 WO2007106915A2 (en) 2006-03-16 2007-03-16 Antibodies to egfl7 and methods for their use

Country Status (20)

Country Link
US (3) US20100203041A1 (en)
EP (2) EP2468772A3 (en)
JP (2) JP5363972B2 (en)
KR (1) KR101038633B1 (en)
AR (1) AR059851A1 (en)
AU (1) AU2007226522B2 (en)
BR (1) BRPI0707047A2 (en)
CA (1) CA2646513A1 (en)
CO (1) CO6180454A2 (en)
CR (1) CR10280A (en)
EC (1) ECSP088743A (en)
IL (3) IL193514A0 (en)
MA (1) MA30331B1 (en)
MX (1) MX2008011663A (en)
NO (1) NO20084320L (en)
NZ (2) NZ595863A (en)
PH (1) PH12013502194A1 (en)
RU (1) RU2415870C2 (en)
TW (1) TW201446798A (en)
WO (1) WO2007106915A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10113776B4 (en) * 2001-03-21 2012-08-09 "Iba Gmbh" Isolated streptavidin-binding, competitively elutable peptide, this comprehensive fusion peptide, nucleic acid coding therefor, expression vector, methods for producing a recombinant fusion protein and methods for detecting and / or obtaining the fusion protein
AR059851A1 (en) * 2006-03-16 2008-04-30 Genentech Inc ANTIBODIES OF EGFL7 AND METHODS OF USE
WO2010034155A1 (en) * 2008-09-25 2010-04-01 中南大学湘雅医院 Kit by detecting egfl7 in samples for the diagnosis of hepatocellular carcinoma and its application
CA2838400A1 (en) 2009-05-08 2010-11-11 Genentech, Inc. Humanized anti-egfl7 antibodies and methods using same
TWI560199B (en) * 2010-08-31 2016-12-01 Sanofi Sa Peptide or peptide complex binding to α2 integrin and methods and uses involving the same
KR20140012080A (en) * 2011-02-02 2014-01-29 제넨테크, 인크. Dosing for treatment with anti-egfl7 antibodies
WO2013061112A1 (en) 2011-10-24 2013-05-02 Centre National De La Recherche Scientifique Use of egfl7 modulators for promoting or inhibiting migration of immune cells across vascular endothelium
KR20140142733A (en) * 2012-03-27 2014-12-12 런던 헬스 사이언시스 센터 리서치 인코포레이티드 Egfl7 targeting and/or binding polypeptides and methods for inhibiting angiogenesis
MX2018009499A (en) 2016-02-05 2019-05-06 Univ Texas Egfl6 specific monoclonal antibodies and methods of their use.
AU2018257877A1 (en) * 2017-04-24 2019-11-14 Ohio State Innovation Foundation Recombinant EGFL7, EGFL7 antibodies, and uses thereof

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WO2005117968A2 (en) * 2004-04-14 2005-12-15 Genentech, Inc. Compositions and methods comprising an egfl7 antagonist for modulating vascular development

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