WO2007105154A3 - Antibiotic compounds - Google Patents

Antibiotic compounds Download PDF

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Publication number
WO2007105154A3
WO2007105154A3 PCT/IB2007/050784 IB2007050784W WO2007105154A3 WO 2007105154 A3 WO2007105154 A3 WO 2007105154A3 IB 2007050784 W IB2007050784 W IB 2007050784W WO 2007105154 A3 WO2007105154 A3 WO 2007105154A3
Authority
WO
WIPO (PCT)
Prior art keywords
represent
alkyl
hydrogen
halogen
ch2ch
Prior art date
Application number
PCT/IB2007/050784
Other languages
French (fr)
Other versions
WO2007105154A2 (en
Inventor
Jean-Christophe Gauvin
Christian Hubschwerlen
Jean-Philippe Surivet
Acklin Cornelia Zumbrunn
Original Assignee
Actelion Pharmaceuticals Ltd
Jean-Christophe Gauvin
Christian Hubschwerlen
Jean-Philippe Surivet
Acklin Cornelia Zumbrunn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd, Jean-Christophe Gauvin, Christian Hubschwerlen, Jean-Philippe Surivet, Acklin Cornelia Zumbrunn filed Critical Actelion Pharmaceuticals Ltd
Priority to CA002643962A priority Critical patent/CA2643962A1/en
Priority to JP2008557888A priority patent/JP2009529525A/en
Priority to EP07713226A priority patent/EP1996579A2/en
Publication of WO2007105154A2 publication Critical patent/WO2007105154A2/en
Publication of WO2007105154A3 publication Critical patent/WO2007105154A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The invention relates to selected antibiotics of formula (Al) wherein R1 represents alkyl, alkoxy, haloalkoxy, halogen or cyano; one or two of U, V, W and X represent(s) N, the remaining represent CH, or, in case of U, V and/or W, may also represent CRa and, in the case of X, may also represent CRb, Ra representing halogen and Rb representing halogen or alkoxy; A3 represents NHCO, CH2CH2, CH=CH, COCH2, CH(OH)CH2, CH2CH(OH), CH(OH)CH(OH) or OCH2; A4 represents CH2, CO, CH2CH=CH, COCH=CH or CH2CONH; R2 represents hydrogen, alkyl, hydroxyalkyl, alkylcarbonyloxyalkyl, carbamoyloxyalkyl, carboxyalkyl or carbamoylalkyl; R3 and R4 each independently represent hydrogen, hydroxy or alkylcarbonyloxy; or R3 and R4 together represent a bridged dimethylmethylenedioxy chain attached to the carbons bearing R3 and R4; R5 represents hydrogen, alkyl or hydroxyalkyl; and the dotted line represents a single bond or, when R3 and R4 represent hydrogen, also a double bond; and D represents alkyl, aryl or heteroaryl. An example of such an antibiotic is (E)-2-{(2R,3R,6R)-3-[3-(2,5-difluoro-phenyl)- allylamino]-6-[2-(6-methoxy-[l,5]naphthyridin-4-yl)-ethyl]-tetrahydro-pyran-2-yl}-ethanol.
PCT/IB2007/050784 2006-03-10 2007-03-09 Antibiotic compounds WO2007105154A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002643962A CA2643962A1 (en) 2006-03-10 2007-03-09 Antibiotic compounds
JP2008557888A JP2009529525A (en) 2006-03-10 2007-03-09 Antibacterial compounds
EP07713226A EP1996579A2 (en) 2006-03-10 2007-03-09 Antibiotic compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IBPCT/IB2006/050762 2006-03-10
IB2006050762 2006-03-10

Publications (2)

Publication Number Publication Date
WO2007105154A2 WO2007105154A2 (en) 2007-09-20
WO2007105154A3 true WO2007105154A3 (en) 2007-12-13

Family

ID=38267680

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/050784 WO2007105154A2 (en) 2006-03-10 2007-03-09 Antibiotic compounds

Country Status (5)

Country Link
EP (1) EP1996579A2 (en)
JP (1) JP2009529525A (en)
CN (1) CN101400674A (en)
CA (1) CA2643962A1 (en)
WO (1) WO2007105154A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009013254A (en) * 2007-06-15 2010-01-25 Actelion Pharmaceuticals Ltd 3-amino-6-(1-amino-ethyl)-tetrahydropyran derivatives.
MX2010006111A (en) 2007-12-18 2010-06-25 Actelion Pharmaceuticals Ltd 5-aminocyclylmethyl-oxazolidin-2-one derivatives.
SI2376497T1 (en) 2008-12-12 2014-01-31 Actelion Pharmaceuticals Ltd. 5-amino-2-(1-hydroxy-ethyl)-tetrahydropyran derivatives
KR20210066857A (en) * 2018-09-27 2021-06-07 쉔젠 칩스크린 바이오사이언스 씨오., 엘티디. Quinoline derivatives having indoleamine-2,3-dioxygenase inhibitory activity
CN115677708A (en) * 2022-10-19 2023-02-03 五邑大学 Preparation method of pyrroloquinoxaline

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004035569A2 (en) * 2002-10-10 2004-04-29 Morphochem Aktiengesellschaft für kombinatorische Chemie Novel compounds with antibacterial activity
WO2004089947A2 (en) * 2003-04-08 2004-10-21 Morphochem Ag Novel compounds having an antibacterial activity
WO2006032466A2 (en) * 2004-09-24 2006-03-30 Actelion Pharmaceuticals Ltd New bicyclic antibiotics
WO2006125974A1 (en) * 2005-05-24 2006-11-30 Astrazeneca Ab Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity
WO2007086016A1 (en) * 2006-01-26 2007-08-02 Actelion Pharmaceuticals Ltd Tetrahydropyrane antibiotics

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004035569A2 (en) * 2002-10-10 2004-04-29 Morphochem Aktiengesellschaft für kombinatorische Chemie Novel compounds with antibacterial activity
WO2004089947A2 (en) * 2003-04-08 2004-10-21 Morphochem Ag Novel compounds having an antibacterial activity
WO2006032466A2 (en) * 2004-09-24 2006-03-30 Actelion Pharmaceuticals Ltd New bicyclic antibiotics
WO2006125974A1 (en) * 2005-05-24 2006-11-30 Astrazeneca Ab Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity
WO2007086016A1 (en) * 2006-01-26 2007-08-02 Actelion Pharmaceuticals Ltd Tetrahydropyrane antibiotics

Also Published As

Publication number Publication date
CN101400674A (en) 2009-04-01
EP1996579A2 (en) 2008-12-03
JP2009529525A (en) 2009-08-20
WO2007105154A2 (en) 2007-09-20
CA2643962A1 (en) 2007-09-20

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