WO2007104773A3 - Use of perfluoropolymers in the determination of the receptor-ligand binding constant - Google Patents

Use of perfluoropolymers in the determination of the receptor-ligand binding constant Download PDF

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Publication number
WO2007104773A3
WO2007104773A3 PCT/EP2007/052390 EP2007052390W WO2007104773A3 WO 2007104773 A3 WO2007104773 A3 WO 2007104773A3 EP 2007052390 W EP2007052390 W EP 2007052390W WO 2007104773 A3 WO2007104773 A3 WO 2007104773A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor
determination
binding constant
perfluoropolymers
ligand binding
Prior art date
Application number
PCT/EP2007/052390
Other languages
French (fr)
Other versions
WO2007104773A2 (en
Inventor
Mattia Bassi
Original Assignee
Solvay Solexis Spa
Mattia Bassi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Solexis Spa, Mattia Bassi filed Critical Solvay Solexis Spa
Priority to JP2008558816A priority Critical patent/JP4950229B2/en
Priority to EP07726884A priority patent/EP1999454A2/en
Priority to US12/293,149 priority patent/US7985600B2/en
Publication of WO2007104773A2 publication Critical patent/WO2007104773A2/en
Publication of WO2007104773A3 publication Critical patent/WO2007104773A3/en
Priority to US13/018,073 priority patent/US8945947B2/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Use of flat surfaces comprising perfluorinated polymers in the determination of the binding constant of two interacting molecular species by using measurements of reflected light intensity, said surface comprising at least one molecule with the receptor function adsorbed or immobilized on said surface, and at least one ligand which interacts with the receptor.
PCT/EP2007/052390 2006-03-16 2007-03-14 Use of perfluoropolymers in the determination of the receptor-ligand binding constant WO2007104773A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2008558816A JP4950229B2 (en) 2006-03-16 2007-03-14 Use of perfluoropolymers in the measurement of receptor-ligand binding constants
EP07726884A EP1999454A2 (en) 2006-03-16 2007-03-14 Use of perfluoropolymers in the determination of the receptor-ligand binding constant
US12/293,149 US7985600B2 (en) 2006-03-16 2007-03-14 Use of perfluoropolymers in the determination of the receptor-ligand binding constant
US13/018,073 US8945947B2 (en) 2006-03-16 2011-01-31 Use of perfluoropolymers in the determination of the receptor-ligand binding constant

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI20060480 ITMI20060480A1 (en) 2006-03-16 2006-03-16 USOM OF PERFLUOROPOLYMERS IN THE DTERMIBNAZIONE OF THE LIGANDO-RECEPTOR BOND CONSTANT
ITMI2006A000480 2006-03-16

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/293,149 A-371-Of-International US7985600B2 (en) 2006-03-16 2007-03-14 Use of perfluoropolymers in the determination of the receptor-ligand binding constant
US13/018,073 Continuation US8945947B2 (en) 2006-03-16 2011-01-31 Use of perfluoropolymers in the determination of the receptor-ligand binding constant

Publications (2)

Publication Number Publication Date
WO2007104773A2 WO2007104773A2 (en) 2007-09-20
WO2007104773A3 true WO2007104773A3 (en) 2007-11-01

Family

ID=38352420

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/052390 WO2007104773A2 (en) 2006-03-16 2007-03-14 Use of perfluoropolymers in the determination of the receptor-ligand binding constant

Country Status (5)

Country Link
US (2) US7985600B2 (en)
EP (1) EP1999454A2 (en)
JP (1) JP4950229B2 (en)
IT (1) ITMI20060480A1 (en)
WO (1) WO2007104773A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20060480A1 (en) * 2006-03-16 2007-09-17 Solvay Solexis Spa USOM OF PERFLUOROPOLYMERS IN THE DTERMIBNAZIONE OF THE LIGANDO-RECEPTOR BOND CONSTANT
ITMI20060477A1 (en) * 2006-03-16 2007-09-17 Univ Degli Studi Milano METHOD OF MEASUREMENT OF MOLECULAR INTERACTIONS THROUGH SURFACES LIGHT DETECTION

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5152287A (en) * 1990-08-15 1992-10-06 Cordis Corporation Cross-linked fluorinated polymers for use in gas sensors
WO2000048023A1 (en) * 1999-02-10 2000-08-17 Waters Investments Limited Flow cell, analyte measurement apparatus and methods related thereto
US20010023077A1 (en) * 1998-03-20 2001-09-20 Erb Judith L. Method and apparatus for measurement of binding between a protein and a nucleotide
US20030017078A1 (en) * 2000-10-16 2003-01-23 Thilo Trapp Optical sensor for determining an analyte, and method of manufacturing the optical sensor
US20040115823A1 (en) * 2002-12-12 2004-06-17 Potyrailo Radislav Alexandrovi Method for improvement of environmental stability and selectivity of materials for sensors
WO2006032419A1 (en) * 2004-09-21 2006-03-30 Solvay Solexis S.P.A. Use of perfluoropolymer submicrometric latexes in the determination of molecular interactions by laser light scattering (lls)

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4485250A (en) * 1981-11-19 1984-11-27 E. I. Du Pont De Nemours And Company Perfluorodioxole and its polymers
US4703018A (en) * 1985-02-20 1987-10-27 E. I. Du Pont De Nemours And Company High refractive index haloalkyl-functional shell-core polymers and their use in light scattering immunoassays
IT1187684B (en) * 1985-07-08 1987-12-23 Montefluos Spa PROCEDURE FOR THE PREPARATION OF VULCANIZABLE FLUOROELASTOMERS AND PRODUCTS SO OBTAINED
IT1189092B (en) * 1986-04-29 1988-01-28 Ausimont Spa POLYMERIZATION PROCESS IN WATER DISPERSION OF FLUORINATED MONOMERS
IT1204903B (en) * 1986-06-26 1989-03-10 Ausimont Spa POLYMERIZATION PROCESS IN WATER DISPERSION OF FLORATED MONOMERS
IL82308A (en) 1986-06-26 1990-11-29 Ausimont Spa Microemulsions containing perfluoropolyethers
US5079155A (en) * 1987-03-02 1992-01-07 E. I. Du Pont De Nemours And Company Fluorocarbon polymer support for chromatographic separations, diagnostic assays and enzyme immobilization
US4910276A (en) * 1987-08-14 1990-03-20 Asahi Glass Company, Ltd. Cyclic polymerization
SE462408B (en) * 1988-11-10 1990-06-18 Pharmacia Ab OPTICAL BIOSENSOR SYSTEM USING SURFACE MONITORING RESONSE FOR THE DETECTION OF A SPECIFIC BIOMOLIC CYCLE, TO CALIBRATE THE SENSOR DEVICE AND TO CORRECT FOUND BASELINE OPERATION IN THE SYSTEM
IT1235545B (en) * 1989-07-10 1992-09-09 Ausimont Srl FLUOROELASTOMERS EQUIPPED WITH BETTER PROCESSABILITY AND PREPARATION PROCEDURE
US5266498A (en) * 1989-10-27 1993-11-30 Abbott Laboratories Ligand binding assay for an analyte using surface-enhanced scattering (SERS) signal
US5270193A (en) * 1989-10-27 1993-12-14 E. I. Dupont De Nemours And Company Immobilization of biomolecules on perfluorocarbon surfaces
GB9019123D0 (en) * 1990-09-01 1990-10-17 Fisons Plc Analytical device
US5324633A (en) * 1991-11-22 1994-06-28 Affymax Technologies N.V. Method and apparatus for measuring binding affinity
IT1264662B1 (en) 1993-07-05 1996-10-04 Ausimont Spa PERFLURODIOSSOLS THEIR HOMOPOLYMERS AND COPOLYMERS AND THEIR USE FOR THE COATING OF ELECTRIC CABLES
IT1265461B1 (en) * 1993-12-29 1996-11-22 Ausimont Spa FLUOROELASTOMERS INCLUDING MONOMERIC UNITS ARISING FROM A BIS-OLEPHINE
US5690907A (en) * 1995-06-08 1997-11-25 The Jewish Hospital Of St. Louis Avidin-biotin conjugated emulsions as a site specific binding system
US5939021A (en) * 1997-01-23 1999-08-17 Hansen; W. Peter Homogeneous binding assay
US6413786B1 (en) * 1997-01-23 2002-07-02 Union Biometrica Technology Holdings, Inc. Binding assays using optical resonance of colloidal particles
JP4209471B2 (en) * 1997-02-20 2009-01-14 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Plasmon resonant particles, methods, and apparatus
AU751932B2 (en) * 1997-10-15 2002-08-29 Polarx Biopharmaceuticals, Inc. Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds
ITMI981519A1 (en) * 1998-07-02 2000-01-02 Ausimont Spa POLYMERIZATION PROCESS OF TFE
DE19938369B4 (en) 1999-08-09 2004-08-19 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method and device for the detection of molecular interactions via molecular motors
ATE320605T1 (en) * 2000-05-05 2006-04-15 DOPPED NANOPARTICLES AS A BIOLABEL
JPWO2003029822A1 (en) * 2001-09-28 2005-01-20 松下電器産業株式会社 Specific binding analyzer and specific binding analysis method
EP1300684A1 (en) 2001-10-08 2003-04-09 Barts and The London National Health Service Trust Homogenous ligand binding assay
JP2004125748A (en) * 2002-10-07 2004-04-22 Nec Corp Sensor
ITMI20030773A1 (en) * 2003-04-15 2004-10-16 Solvay Solexis Spa AMORPHOUS PERFLUORATED POLYMERS.
US7736889B2 (en) * 2003-06-10 2010-06-15 The United States Of America As Represented By The Secretary Of The Navy Fluidic force discrimination
ITMI20041251A1 (en) * 2004-06-22 2004-09-22 Solvay Solexis Spa PERFLUOROELASTOMER GEL
ITMI20060480A1 (en) * 2006-03-16 2007-09-17 Solvay Solexis Spa USOM OF PERFLUOROPOLYMERS IN THE DTERMIBNAZIONE OF THE LIGANDO-RECEPTOR BOND CONSTANT

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5152287A (en) * 1990-08-15 1992-10-06 Cordis Corporation Cross-linked fluorinated polymers for use in gas sensors
US20010023077A1 (en) * 1998-03-20 2001-09-20 Erb Judith L. Method and apparatus for measurement of binding between a protein and a nucleotide
WO2000048023A1 (en) * 1999-02-10 2000-08-17 Waters Investments Limited Flow cell, analyte measurement apparatus and methods related thereto
US20030017078A1 (en) * 2000-10-16 2003-01-23 Thilo Trapp Optical sensor for determining an analyte, and method of manufacturing the optical sensor
US20040115823A1 (en) * 2002-12-12 2004-06-17 Potyrailo Radislav Alexandrovi Method for improvement of environmental stability and selectivity of materials for sensors
WO2006032419A1 (en) * 2004-09-21 2006-03-30 Solvay Solexis S.P.A. Use of perfluoropolymer submicrometric latexes in the determination of molecular interactions by laser light scattering (lls)

Also Published As

Publication number Publication date
ITMI20060480A1 (en) 2007-09-17
JP4950229B2 (en) 2012-06-13
US20110207235A1 (en) 2011-08-25
US7985600B2 (en) 2011-07-26
EP1999454A2 (en) 2008-12-10
JP2009530592A (en) 2009-08-27
US8945947B2 (en) 2015-02-03
US20090042316A1 (en) 2009-02-12
WO2007104773A2 (en) 2007-09-20

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