WO2007104442A3 - Process for the manufacture of a precursor of vitamin b1 - Google Patents

Process for the manufacture of a precursor of vitamin b1 Download PDF

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Publication number
WO2007104442A3
WO2007104442A3 PCT/EP2007/001859 EP2007001859W WO2007104442A3 WO 2007104442 A3 WO2007104442 A3 WO 2007104442A3 EP 2007001859 W EP2007001859 W EP 2007001859W WO 2007104442 A3 WO2007104442 A3 WO 2007104442A3
Authority
WO
WIPO (PCT)
Prior art keywords
vitamin
precursor
manufacture
acylaminomethyl
pyrimidine
Prior art date
Application number
PCT/EP2007/001859
Other languages
French (fr)
Other versions
WO2007104442A2 (en
Original Assignee
Dsm Ip Assets B.V.
Eisele, Frank
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets B.V., Eisele, Frank filed Critical Dsm Ip Assets B.V.
Priority to CN200780009190.1A priority Critical patent/CN101627017B/en
Publication of WO2007104442A2 publication Critical patent/WO2007104442A2/en
Publication of WO2007104442A3 publication Critical patent/WO2007104442A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

A process for the preparation of Grewe diamine by treatment of 4-amino-2-methyl-5-acylaminomethyl-pyrimidine in aqueous solution with an ion exchange resin.
PCT/EP2007/001859 2006-03-15 2007-03-05 Process for the manufacture of a precursor of vitamin b1 WO2007104442A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN200780009190.1A CN101627017B (en) 2006-03-15 2007-03-05 Process for the manufacture of a precursor of vitamin b1

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06005262.8 2006-03-15
EP06005262 2006-03-15

Publications (2)

Publication Number Publication Date
WO2007104442A2 WO2007104442A2 (en) 2007-09-20
WO2007104442A3 true WO2007104442A3 (en) 2009-09-11

Family

ID=38509829

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/001859 WO2007104442A2 (en) 2006-03-15 2007-03-05 Process for the manufacture of a precursor of vitamin b1

Country Status (2)

Country Link
CN (1) CN101627017B (en)
WO (1) WO2007104442A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010010113A1 (en) * 2008-07-22 2010-01-28 Dsm Ip Assets B.V. Novel synthesis of substituted 4-amino-pyrimidines
WO2012075677A1 (en) * 2010-12-10 2012-06-14 Dsm Ip Assets B.V. Method for preparation of 2-methyl-4-amtno-5-cyanopyrimidine
CN104031038B (en) * 2014-07-04 2016-06-08 东北制药集团股份有限公司 The method of vitamin b1 hydrochloride prepared by a kind of sulphur hydroxyl thiamines
CN104326989B (en) * 2014-11-26 2016-04-27 江西天新药业有限公司 The preparation method of 2-methyl-4-amino-5-(amino methyl) pyrimidine
CN108546249B (en) * 2018-02-28 2021-10-01 东北制药集团股份有限公司 Method for preparing bisamine pyrimidine
CN114230488A (en) * 2021-12-27 2022-03-25 江苏兄弟维生素有限公司 Preparation method and application of alpha- (o-chloroaniline) based methine-beta-formamido propionitrile

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0103126A1 (en) * 1982-09-10 1984-03-21 Ube Industries, Ltd. Process for preparing 4-amino-5-dialkoxymethylpyrimidine derivatives
DE3511273A1 (en) * 1985-03-28 1986-10-09 Basf Ag, 6700 Ludwigshafen Improved process for the preparation of 2-methyl-4-amino-5-aminomethylpyrimidine
WO2006079504A2 (en) * 2005-01-28 2006-08-03 Dsm Ip Assets B.V. Process for the manufacture of a precursor of vitamin b1

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0103126A1 (en) * 1982-09-10 1984-03-21 Ube Industries, Ltd. Process for preparing 4-amino-5-dialkoxymethylpyrimidine derivatives
DE3511273A1 (en) * 1985-03-28 1986-10-09 Basf Ag, 6700 Ludwigshafen Improved process for the preparation of 2-methyl-4-amino-5-aminomethylpyrimidine
WO2006079504A2 (en) * 2005-01-28 2006-08-03 Dsm Ip Assets B.V. Process for the manufacture of a precursor of vitamin b1

Also Published As

Publication number Publication date
CN101627017A (en) 2010-01-13
WO2007104442A2 (en) 2007-09-20
CN101627017B (en) 2013-02-27

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