WO2007103584A3 - Polyamides pour le traitement du virus du papillome humain - Google Patents

Polyamides pour le traitement du virus du papillome humain Download PDF

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Publication number
WO2007103584A3
WO2007103584A3 PCT/US2007/006133 US2007006133W WO2007103584A3 WO 2007103584 A3 WO2007103584 A3 WO 2007103584A3 US 2007006133 W US2007006133 W US 2007006133W WO 2007103584 A3 WO2007103584 A3 WO 2007103584A3
Authority
WO
WIPO (PCT)
Prior art keywords
polyamides
papilloma virus
human papilloma
treating human
treating
Prior art date
Application number
PCT/US2007/006133
Other languages
English (en)
Other versions
WO2007103584A2 (fr
Inventor
James Bashkin
Christopher Fisher
Kevin J Koeller
Original Assignee
Nanovir Llc
James Bashkin
Christopher Fisher
Kevin J Koeller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanovir Llc, James Bashkin, Christopher Fisher, Kevin J Koeller filed Critical Nanovir Llc
Priority to PCT/US2007/010907 priority Critical patent/WO2007130616A2/fr
Priority to ES07776781T priority patent/ES2387249T3/es
Priority to US11/800,105 priority patent/US7589171B2/en
Priority to EP07776781A priority patent/EP2013200B1/fr
Priority to JP2009509753A priority patent/JP5371743B2/ja
Priority to AT07776781T priority patent/ATE555108T1/de
Publication of WO2007103584A2 publication Critical patent/WO2007103584A2/fr
Publication of WO2007103584A3 publication Critical patent/WO2007103584A3/fr
Priority to US12/534,666 priority patent/US9333232B2/en
Priority to US12/534,693 priority patent/US8119677B2/en
Priority to US13/357,740 priority patent/US8993609B2/en
Priority to JP2013129779A priority patent/JP5796039B2/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use

Abstract

La présente invention concerne des polyamides pour traiter le VPH.
PCT/US2007/006133 2006-03-09 2007-03-09 Polyamides pour le traitement du virus du papillome humain WO2007103584A2 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
AT07776781T ATE555108T1 (de) 2006-05-04 2007-05-04 Polyamide zur behandlung des menschlichen papilloma-virus
ES07776781T ES2387249T3 (es) 2006-05-04 2007-05-04 Poliamidas para el tratamiento del virus del papiloma humano
US11/800,105 US7589171B2 (en) 2006-05-04 2007-05-04 Polyamides for treating human papilloma virus
EP07776781A EP2013200B1 (fr) 2006-05-04 2007-05-04 Polyamides destines au traitement du papillomavirus humain
JP2009509753A JP5371743B2 (ja) 2006-05-04 2007-05-04 ヒトパピローマウイルスを処置するためのポリアミド類
PCT/US2007/010907 WO2007130616A2 (fr) 2006-05-04 2007-05-04 Polyamides destinés au traitement du papillomavirus humain
US12/534,666 US9333232B2 (en) 2006-05-04 2009-08-03 Methods for treating papilloma virus infection
US12/534,693 US8119677B2 (en) 2006-05-04 2009-08-03 Polyamides containing amino butyric acid-based building blocks
US13/357,740 US8993609B2 (en) 2006-05-04 2012-01-25 Compounds for treating papilloma virus infection
JP2013129779A JP5796039B2 (ja) 2006-05-04 2013-06-20 ヒトパピローマウイルスを処置するためのポリアミド類

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US78054006P 2006-03-09 2006-03-09
US60/780,540 2006-03-09
US79742606P 2006-05-04 2006-05-04
US60/797,426 2006-05-04

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/800,105 Continuation US7589171B2 (en) 2006-05-04 2007-05-04 Polyamides for treating human papilloma virus

Publications (2)

Publication Number Publication Date
WO2007103584A2 WO2007103584A2 (fr) 2007-09-13
WO2007103584A3 true WO2007103584A3 (fr) 2007-11-08

Family

ID=38325386

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/006133 WO2007103584A2 (fr) 2006-03-09 2007-03-09 Polyamides pour le traitement du virus du papillome humain

Country Status (1)

Country Link
WO (1) WO2007103584A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9493437B2 (en) 2010-08-18 2016-11-15 Samumed, Llc β- and γ-diketones and γ-hydroxyketones as Wnt/ β-catenin signaling pathway activators
US9533976B2 (en) 2013-02-22 2017-01-03 Samumed, Llc γ-diketones as WNT/β-catenin signaling pathway activators

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8993609B2 (en) 2006-05-04 2015-03-31 Nanovir, Llc Compounds for treating papilloma virus infection
US9133228B2 (en) 2011-10-10 2015-09-15 Nanovir Llc Guanidinyl-substituted polyamides useful for treating human papilloma virus
US9982020B2 (en) 2011-10-10 2018-05-29 Nanovir Llc Antiviral compounds and methods for treating infections caused by double-stranded DNA viruses
HUE046741T2 (hu) 2014-08-20 2020-03-30 Samumed Llc Gamma-diketonok bõröregedés és ráncok megelõzésére és kezelésére
CN113042016A (zh) * 2021-04-25 2021-06-29 上海捷门生物技术有限公司 用于纯化抗血清的固相亲和吸附剂以及获得纯化的抗体的方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998035702A1 (fr) * 1996-08-01 1998-08-20 California Institute Of Technology Inhibition de la transcription de genes par des ligands de polyamide se fixant a l'adn
WO1998037067A1 (fr) * 1996-02-26 1998-08-27 California Institute Of Technology Conception, synthese et utilisation de ligands a base de polyamides specifiques pour liaison a l'adn
WO1998037066A1 (fr) * 1996-02-26 1998-08-27 California Institute Of Technology Polyamides ameliores pour assurer une liaison dans le sillon mineur de l'adn a double brins
WO1998050058A1 (fr) * 1997-05-08 1998-11-12 California Institute Of Technology Formation de complexes entre un adn a double brin et un oligomere d'heterocycles
WO2000015773A2 (fr) * 1998-09-11 2000-03-23 California Institute Of Technology Inhibition de transcription d'oncogenes par des polyamides synthetiques
WO2005033282A2 (fr) * 2003-10-01 2005-04-14 Pharmacia & Upjohn Company Llc Compositions polyamide et methodes therapeutiques pour traiter un papillomavirus humain

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998037067A1 (fr) * 1996-02-26 1998-08-27 California Institute Of Technology Conception, synthese et utilisation de ligands a base de polyamides specifiques pour liaison a l'adn
WO1998037066A1 (fr) * 1996-02-26 1998-08-27 California Institute Of Technology Polyamides ameliores pour assurer une liaison dans le sillon mineur de l'adn a double brins
WO1998035702A1 (fr) * 1996-08-01 1998-08-20 California Institute Of Technology Inhibition de la transcription de genes par des ligands de polyamide se fixant a l'adn
WO1998050058A1 (fr) * 1997-05-08 1998-11-12 California Institute Of Technology Formation de complexes entre un adn a double brin et un oligomere d'heterocycles
WO2000015773A2 (fr) * 1998-09-11 2000-03-23 California Institute Of Technology Inhibition de transcription d'oncogenes par des polyamides synthetiques
WO2005033282A2 (fr) * 2003-10-01 2005-04-14 Pharmacia & Upjohn Company Llc Compositions polyamide et methodes therapeutiques pour traiter un papillomavirus humain

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
COULL, J.J. ET AL.: "Targeted derepression of the human immunodeficiency virus type 1 long terminal repeat by pyrrole-imidazole polyamides", JOURNAL OF VIROLOGY, vol. 76, no. 23, 2002, pages 12349 - 12354, XP003010845, ISSN: 0022-538X *
EDELSON, B.S. ET AL.: "Influence of structural variation on nuclear localization of DNA-binging polyamide-fluorophore conjugates", NUCLEIC ACIDS RESEARCH, vol. 32, no. 9, 2004, pages 2802 - 2818, XP002448159 *
TURNER, J.M. ET AL.: "ALIPHATIC/AROMATIC AMINO ACID PAIRINGS FOR POLYAMIDE RECOGNITION IN THE MINOR GROOVE OF DNA", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 120, 1998, pages 6219 - 6226, XP000879892, ISSN: 0002-7863 *
TURNER, J.M. ET AL.: "RECOGNITION OF SEVEN BASE PAIR SEQUENCES IN THE MINOR GROOVE OF DNA BY TEN-RING PYRROLE-IMIDAZOLE POLYAMIDE HAIRPINS", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 119, no. 33, 1997, pages 7636 - 7644, XP002072060, ISSN: 0002-7863 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9493437B2 (en) 2010-08-18 2016-11-15 Samumed, Llc β- and γ-diketones and γ-hydroxyketones as Wnt/ β-catenin signaling pathway activators
US9533976B2 (en) 2013-02-22 2017-01-03 Samumed, Llc γ-diketones as WNT/β-catenin signaling pathway activators

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