WO2007103492A3 - Cellular predictive models for toxicities - Google Patents
Cellular predictive models for toxicities Download PDFInfo
- Publication number
- WO2007103492A3 WO2007103492A3 PCT/US2007/005916 US2007005916W WO2007103492A3 WO 2007103492 A3 WO2007103492 A3 WO 2007103492A3 US 2007005916 W US2007005916 W US 2007005916W WO 2007103492 A3 WO2007103492 A3 WO 2007103492A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- toxicities
- predictive models
- models
- stimuli
- subset
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5067—Liver cells
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V20/00—Scenes; Scene-specific elements
- G06V20/60—Type of objects
- G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
- G06V20/695—Preprocessing, e.g. image segmentation
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Theoretical Computer Science (AREA)
- Multimedia (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Management, Administration, Business Operations System, And Electronic Commerce (AREA)
Abstract
Methods for generating models for predicting biological activity of a stimulus test population of cells are provided. The models may be used to classify or predict the effect of stimuli on cells. In certain embodiments, the methods involve receiving data comprising values for dependent variables associated with stimuli; preparing a set of cell populations based on the data received; identifying a subset of the cell populations to be used in generating a model from data associated with the subset, wherein the model is provided to predict activity of a test population.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78103306P | 2006-03-09 | 2006-03-09 | |
US60/781,033 | 2006-03-09 | ||
US78267606P | 2006-03-14 | 2006-03-14 | |
US60/782,676 | 2006-03-14 | ||
GB0605362A GB2435926A (en) | 2006-03-09 | 2006-03-17 | Cellular predictive models for phospholipidosis |
GB0605362.3 | 2006-03-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007103492A2 WO2007103492A2 (en) | 2007-09-13 |
WO2007103492A3 true WO2007103492A3 (en) | 2008-10-23 |
Family
ID=38475559
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/005916 WO2007103492A2 (en) | 2006-03-09 | 2007-03-07 | Cellular predictive models for toxicities |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2007103492A2 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2652562C (en) | 2006-05-17 | 2015-05-12 | Cellumen, Inc. | Method for automated tissue analysis |
EP2686688B1 (en) | 2011-03-17 | 2019-05-08 | Cernostics, Inc. | Systems and compositions for diagnosing barrett's esophagus and methods of using the same |
WO2013109856A2 (en) * | 2012-01-18 | 2013-07-25 | Genentech, Inc. | Methods of using fgf19 modulators |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040086873A1 (en) * | 2002-10-31 | 2004-05-06 | Johnson Peter C. | System and method of generating and storing correlated hyperquantified tissue structure and biomolecular expression datasets |
US20050014217A1 (en) * | 2003-07-18 | 2005-01-20 | Cytokinetics, Inc. | Predicting hepatotoxicity using cell based assays |
US6873914B2 (en) * | 2001-11-21 | 2005-03-29 | Icoria, Inc. | Methods and systems for analyzing complex biological systems |
-
2007
- 2007-03-07 WO PCT/US2007/005916 patent/WO2007103492A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6873914B2 (en) * | 2001-11-21 | 2005-03-29 | Icoria, Inc. | Methods and systems for analyzing complex biological systems |
US20040086873A1 (en) * | 2002-10-31 | 2004-05-06 | Johnson Peter C. | System and method of generating and storing correlated hyperquantified tissue structure and biomolecular expression datasets |
US20050014217A1 (en) * | 2003-07-18 | 2005-01-20 | Cytokinetics, Inc. | Predicting hepatotoxicity using cell based assays |
Non-Patent Citations (2)
Title |
---|
ERLER, BS ET AL.: "A Study of Hepatocellular Carcinoma Using Morphometric and Densitometric Image Analysis.", AMERICAN JOURNAL OF CLINICAL PATHOLOGY., vol. 100, 1993, pages 151 - 157, XP055354593 * |
ERLER, BS ET AL.: "Methods in Laboratory Investigation: Image Analysis.and Diagnostic Classification of Hepatocellular Carcinoma Using Neural Networks and Multivariate Discriminant Functions.", LABORATORY INVESTIGATION., vol. 7 1, no. 3, 1994, pages 446 - 451 * |
Also Published As
Publication number | Publication date |
---|---|
WO2007103492A2 (en) | 2007-09-13 |
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